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Located in Newsroom / UNC Lineberger in the News
New insights into side effects can help prostate cancer patients choose treatments
In the Journal of the American Medical Association, a study led by UNC Lineberger member Ronald C. Chen, MD, examines quality-of-life outcomes for modern treatment choices most patients will face, including active surveillance, radical prostatectomy, external beam radiation treatment, and brachytherapy.
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Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy
In a pair of preclinical studies published in the journal Neuro-Oncology, UNC Lineberger's C. Ryan Miller, MD, PhD, and the Phoenix-based Translational Genomics Research Institute report on the genetic evolution of glioblastoma as it progresses in severity and a potential strategy to treat this often fast-growing brain cancer type.
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Finding genetic variations common in black women could improve breast cancer outcomes, reduce recurrence
UNC Lineberger researchers Charles M. Perou, PhD, Katherine Hoadley, PhD, and Melissa Troester, PhD, co-authored a large, multi-institutional study designed to understand a gap in mortality for black and white women with breast cancer by beginning to unravel the germline genetic variations and tumor biological differences. This is the first “ancestry-based comprehensive analysis of multiple platforms of genomic and proteomic data of its kind,” the authors note.
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Promising results found for treatment of melanoma in the brain
At the American Society of Clinical Oncology Annual Meeting 2017 in Chicago, researchers presented promising data for two different investigational drug regimens used to treat melanoma that has spread to the brain, a common and deadly complication of this cancer.
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In ovarian cancer, researchers uncover new drivers of cell division
UNC Lineberger's Michael J. Emanuele, PhD, and colleagues have identified a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide, a finding they published in the journal Molecular and Cellular Biology. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.
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Located in Newsroom / UNC Lineberger in the News
Located in Newsroom / UNC Lineberger in the News
Researchers awarded grant to study strategy to improve immunotherapy response
With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.
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Patients and their records agree on medical history for most maladies
A study led by UNC Lineberger researcher Ronald Chen, MD, found that a group of prostate cancer patients reliably reported their own medical histories when their responses were compared to their medical records.
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