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UNC Lineberger researchers help map the cancer genome, generate key insights
UNC Lineberger researchers led two major projects to mark the finale of The Cancer Genome Atlas project, which was backed by the National Cancer Institute and National Human Genome Research Institute.
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UNC Lineberger breast cancer researcher wins ASCO foundation grant
Katherine Reeder-Hayes, MD, MBA, Msc, a UNC Lineberger member and a clinical assistant professor in the University of North Carolina School of Medicine, won a Career Development Award from the Conquer Cancer Foundation of the American Society of Clinical Oncology. She was one of 11 clinical investigators chosen to receive the three-year award, which goes to researcher-physicians to help them build independent clinical research programs.
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UNC researchers create DNA repair map of the entire human genome
The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
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Researchers find new approach to treat drug-resistant HER2-positive breast cancer
Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.
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A new era for genetic interpretation
UNC Lineberger researchers are collaborating through the ClinGen consortium - a program launched to evaluate the clinical relevance of genetic variants - to help physicians make predictions about an individual’s risk of disease, develop more accurate clinical trials and design individualized treatments and care for patients.
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Precision medicine at UNC: Looking for cancer-driving gene mutations across cancers
UNC Lineberger will be enrolling patients into a new, national clinical trial, known as NCI-MATCH, that will group patients based on the genetics of their tumors as opposed to where their cancer is located. The new initiative will test more than 20 drugs or drug combinations targeting specific genetic mutations.
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Genomic analysis of thousands of tumors supports new cancer classification
A study by researchers from The Cancer Genome Atlas (TCGA) Network, and led by UNC Lineberger's Katherine Hoadley, PhD, supports an additional classification for human tumors.
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Patient, doctor connect through rare cancer diagnosis
In March of 2011, when she was 14 years old, Lily Newton was diagnosed with a rare cancer of the bone and soft tissue called Ewing sarcoma. Cancer changed Newton’s life in more ways than she could have imagined.
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By solving a mystery of gene repair, scientists uncover an exception to biology’s rules
UNC Lineberger's Dale Ramsden, PhD, and his colleagues published a major study in the journal Science revealing surprising findings about the way major breaks in our DNA are repaired.
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Researchers from UNC Lineberger, Norway launch cancer genetics collaboration
Researchers from Norway visited UNC Lineberger Comprehensive Cancer Center to learn firsthand about UNCseq, a clinical trial launched in 2011 at the N.C. Cancer Hospital. In the trial, researchers use a profile of the genetic and molecular alterations in patients' tumors to try to identify targeted treatments for them.
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