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UNC researchers create DNA repair map of the entire human genome
The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
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UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort
UNC sequenced the RNA for 10,000 tumor samples as part of The Cancer Genome Atlas project, a National Cancer Institute and National Human Genome Research Institute-backed effort to create a comprehensive atlas of the genetic changes in cancer.
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Cancer genetics the focus of UNC Lineberger symposium
UNC Lineberger's 39th annual scientific symposium was held April 8-9 at the William and Ida Friday Center for Continuing Education in Chapel Hill.
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Genomic analysis paves way for personalized treatment of invasive lobular carcinoma
UNC Lineberger Comprehensive Cancer Center researchers helped lead an effort by The Cancer Genome Atlas Network of researchers to map the genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer. They found that this cancer type may be at least three different diseases that differ in their microenvironmental features and outcomes.
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Lower survival rates connected with high-risk melanoma with mutations, study finds
A UNC Lineberger-led study found that people with higher-risk melanoma containing either BRAF or NRAS gene mutations had lower survival rates.
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Researchers from UNC Lineberger, Norway launch cancer genetics collaboration
Researchers from Norway visited UNC Lineberger Comprehensive Cancer Center to learn firsthand about UNCseq, a clinical trial launched in 2011 at the N.C. Cancer Hospital. In the trial, researchers use a profile of the genetic and molecular alterations in patients' tumors to try to identify targeted treatments for them.
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UNC Lineberger to partner in $12 million effort to find treatments for genetically-linked cancers
UNC Lineberger Comprehensive Cancer Center researchers and eight other leading cancer research institutions have won a five-year, $12 million grant to try to find treatments for a group of cancers linked to mutations in the NF1 gene.
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A new era for genetic interpretation
UNC Lineberger researchers are collaborating through the ClinGen consortium - a program launched to evaluate the clinical relevance of genetic variants - to help physicians make predictions about an individual’s risk of disease, develop more accurate clinical trials and design individualized treatments and care for patients.
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Pancreatic cancer subtypes discovered in largest gene expression analysis of the disease to-date
A UNC Lineberger-led study, published today in Nature Genetics, paves the way for potential personalized medicine approaches for the deadly cancer type.
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Precision medicine at UNC: Looking for cancer-driving gene mutations across cancers
UNC Lineberger will be enrolling patients into a new, national clinical trial, known as NCI-MATCH, that will group patients based on the genetics of their tumors as opposed to where their cancer is located. The new initiative will test more than 20 drugs or drug combinations targeting specific genetic mutations.
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