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Could reading our circadian clocks according to DNA repair optimize chemotherapy?
For the first time, UNC Lineberger scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.
Located in News
Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse
A team of researchers, including UNC Lineberger's Norman E. Sharpless, MD, has shown that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. Eliminating the senescent cells in mice prevented the side effects and relapse.
Located in News