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Researchers clarify role of mutations in glioblastoma
In a preclinical study, researchers led by UNC Lineberger's Ryan Miller, MD, PhD, investigated whether the location of where the mutation occurred within the sequence of the PIK3CA gene affected the mutation’s ability to help drive cancerous growth. They also evaluated whether the location of the mutation would affect the cancer's response to certain treatments.
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Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy
In a pair of preclinical studies published in the journal Neuro-Oncology, UNC Lineberger's C. Ryan Miller, MD, PhD, and the Phoenix-based Translational Genomics Research Institute report on the genetic evolution of glioblastoma as it progresses in severity and a potential strategy to treat this often fast-growing brain cancer type.
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Bladder cancer model could pave the way for better drug efficacy studies
In the journal Cancer Research, UNC Lineberger’s William Y. Kim, MD, Benjamin G. Vincent, MD, and colleagues reported they have developed a mouse model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to immunotherapy treatments called checkpoint inhibitors.
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UNC Lineberger to use Colon Cancer Coalition grant to promote screening in Eastern North Carolina
UNC Lineberger’s Carolina Cancer Screening Initiative is working in partnership with the Roanoke Chowan Community Health Center in Ahoskie, North Carolina, to improve the colorectal cancer screening rates in a part of the state that has been significantly challenged by this disease.
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Study finds Fitbits can be used to monitor symptoms in transplant patients
UNC Lineberger researchers say the findings of a new study published in the journal Quality of Life Research indicate that activity trackers could be a useful tool for tracking symptoms and physical function. These trackers may be especially useful for patients who are not able to self-report symptoms using questionnaires because of language barriers, literacy, cognitive or health status.
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UNC-Chapel Hill spinout company generates more than $108M in stock offering
Founded with support from KickStart Venture Services, a UNC-Chapel Hill program that works to turn University research into new companies, G1 Therapeutics is developing novel therapeutics based on discoveries at UNC Lineberger Comprehensive Cancer Center.
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Scientists discover interplay of yin-yang antagonists vital for cell division
Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.
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UNC Lineberger-led study tests drug strategy for aggressive breast cancer in the brain
Results from a UNC Lineberger-led study were published Monday in the journal Molecular Cancer Therapeutics. The pre-clinical study was the first to investigate one particular drug strategy as a treatment for breast cancer after it's spread to the brain.
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By forming clots in tumors, immune cells aid lung cancer's spread
Researchers led by UNC Lineberger's Chad Pecot, MD, report in the journal Nature Communications that for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.
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Revolutionary approach for treating glioblastoma works with human cells
UNC Lineberger's Shawn Hingtgen, PhD, and colleagues, in laboratory studies, have converted human skin cells into stem cells that can hunt down and kill human brain cancer, an important step to moving the approach closer to a clinical trial.
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