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Researchers map the genome of testicular cancer
In a collaborative, multi-institution effort to map the genetic and genomic changes in cancer, researchers led by UNC Lineberger's Katherine Hoadley, PhD, analyzed 137 testicular germ cell tumors for potential mutations and other molecular changes. They identified molecular features of testicular germ cell cancers that could inform future efforts to improve treatment decisions, and help monitor patients to see if their cancer has come back. Their findings were published in Cell Reports.
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Blood mutations could contaminate genetic analyses of tumors
UNC Lineberger researchers and colleagues led by Catherine C. Coombs, MD, reported research findings at the 2018 American Society of Clinical Oncology Annual Meeting that showed blood cell mutations accounted for as many as 8 percent of the mutations identified in large-scale genetic sequencing efforts at two major academic centers.
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By forming clots in tumors, immune cells aid lung cancer's spread
Researchers led by UNC Lineberger's Chad Pecot, MD, report in the journal Nature Communications that for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.
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Bladder cancer model could pave the way for better drug efficacy studies
In the journal Cancer Research, UNC Lineberger’s William Y. Kim, MD, Benjamin G. Vincent, MD, and colleagues reported they have developed a mouse model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to immunotherapy treatments called checkpoint inhibitors.
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Breast cancer places greater financial burden on black women
UNC Lineberger's Stephanie Wheeler, PhD, and colleagues report in the Journal of Clinical Oncology that a survey of women who were diagnosed with breast cancer in North Carolina between 2008 and 2013 found that two years after a diagnosis, 58 percent of black women reported a negative financial impact of cancer, compared with 39 percent of white women.
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UNC researchers identify promising delivery method for immunotherapy combination
UNC Lineberger researchers led by Andrew Z. Wang, MD, have published findings in the journal Advanced Materials that could offer a promising new nanotechnology-based delivery method for an immunotherapy combination.
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UNC scientists create better laboratory tools to study cancer’s spread
In the journal Nature Biomedical Engineering, UNC Lineberger’s Andrew Wang, MD, and colleagues report they have developed tissue-engineered models for cancer metastases that reflect the microenvironment around tumors that promotes their growth. They believe their models, which were developed to study colorectal cancer that had spread to the liver and lung, will help scientists studying why cancers tend to spread to certain organs rather than others.
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Cigarillo packaging can influence product perception, study finds
Researchers led by UNC Lineberger's Adam Goldstein, MD, and Clare Meernik, MPH, surveyed 2,664 young adults who were current users, never users, or past users of little cigars and cigarillos, finding cigarillo packs with colors and containing a flavor descriptor were rated more positively for taste and smell. Health warnings didn’t fully mitigate the draw of the packaging.
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Researchers identify molecular target for brain cancer, develop immunotherapy approach to attack it
A team led by UNC Lineberger's Gianpietro Dotti, MD, has engineered immune cells to hunt glioblastoma, the most lethal primary brain tumor. They presented their findings in Science Translational Medicine.
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Researchers define structure, function of enzyme key to blood cancers
In the journal Nature, UNC Lineberger's Greg Wang, PhD, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.
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