With his selection to the NIH Council of Councils, Terry Magnuson, PhD, becomes the first UNC scientist appointed to the board dedicated to funding the biggest ideas in medical research.
Sixteen years after scientists found the genes that control the circadian clock in all cells, the lab of UNC’s Aziz Sancar, MD, PhD, discovered the mechanisms responsible for keeping the clock in sync.
Blossom Damania, PhD, professor of microbiology and immunology, has been named Assistant Dean for Research at the UNC School of Medicine, effective immediately.
New clinical guidelines have been announced for the treatment of men with metastatic castration-resistant prostate cancer (CRPC) by the American Society of Clinical Oncology (ASCO) and Cancer Care Ontario (CCO). Ethan Basch, MD, director of the Cancer Outcomes Research Program at UNC Lineberger Comprehensive Cancer Center, served as the co-chair of the ASCO/CCO expert panel that developed the guideline.
Upstream of the proteins that cancer cells use to proliferate sits RBM4, a gene-splicing protein that UNC researcher Zefeng Wang, PhD, discovered is drastically reduced in human lung and breast cancer cells.
Research led by UNC’s Kathleen Caron, PhD, shows that halting the protein CXCR7 leads to over activation of adrenomedullin, a hormone needed at proper levels for normal cardiovascular development
Thanks to you, 2013-14 was a big year for UNC Lineberger.
UNC Lineberger secures three major NCI grants to advance the nation’s clinical trials program.
Carey Anders, MD, UNC Lineberger member and associate professor, was a presenter and moderator at The 13th Annual Round Asia Oncology Forum (RAOF) in Hong Kong on August 29 - 30, 2014. The theme of this year’s forum was “Expanding our armory in personalized cancer treatment.”
The UNC Eshelman School of Pharmacy has received a $3 million gift from philanthropist and pharmaceutical-industry executive Fred Eshelman. Eshelman’s gift will support the work of the School’s Center for Integrative Chemical Biology and Drug Discovery, led by UNC Lineberger member Stephen Frye, PhD. The center is dedicated to evaluating and developing potential drug targets discovered by UNC faculty.
Six researchers have been awarded 2014 University Cancer Research Fund (UCRF) Innovation Awards for promoting innovative and new ideas in cancer research at the University of North Carolina at Chapel Hill.
UNC Health Care and Rex Healthcare co-sponsored “Field of Hope” at the Durham Bulls game on Saturday, August 23 with a portion of special ticket sales going to the Kay Yow Cancer Fund.
The Lung Cancer Initiative of NC hosted a statewide Lung Cancer Summit on August 23 at the N.C. Cancer Hospital. Lung cancer advocates were bolstered with training, resources, knowledge and the courage to take action. UNC Lineberger Comprehensive Cancer Center was the Host Sponsor of the event.
For more than 20 years, Sharon Campbell, PhD, has been studying Ras, a protein implicated in 30 percent of all cancers. Now she’s on the hunt for alternative ways to shut the protein down.
Kirsten Bryant, PhD, was recently recognized by the Pancreatic Cancer Action Network for her dual role in the fight against pancreatic cancer.
UNC Lineberger Comprehensive Cancer Center researchers have developed a new integrated approach to pinpoint the genetic “drivers” of cancer, uncovering eight genes that could be viable for targeted breast cancer therapy. The study, published online August 24 in Nature Genetics, was authored by Michael Gatza, PhD, lead author and post-doctoral research associate; Grace Silva, graduate student; Joel Parker, PhD, director of bioinformatics, UNC Lineberger; Cheng Fan, research associate; and senior author Chuck Perou, PhD, professor of genetics and pathology.
Part of More Than $24.7 Million Awarded in New Grants by the St. Baldrick’s Foundation
An international scientific collaboration led by researchers at UNC has revealed new insights into the unique genetic alterations that contribute to a rare form of kidney cancer.
A substantial number of older patients with limited life expectancy receive routine screenings for prostate, breast, cervical and colorectal cancer even though the procedures are unlikely to benefit them, according to research conducted at the University of North Carolina at Chapel Hill.
UNC Lineberger Comprehensive Cancer Center has awarded nine researchers with Developmental Research Awards to support their work in advancing the fields of clinical/translational and population science cancer research.
A recent article published in the July/August 2014 issue of Health Leaders magazine focuses on some of UNC Lineberger’s strengths that rank it among the nation’s leading cancer centers.
A recent U.S. News & World Report article highlights the nation’s cancer centers, focusing especially on those that the National Cancer Institute has designated as comprehensive cancer centers, citing advantages of patients being seen at or referred to these sites, including advances in technology and collaboration.
Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work, led by researchers at the UNC Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill and other TCGA sites, not only revamps traditional ideas of how cancers are diagnosed and treated, but could also have a profound impact on the future landscape of drug development.
Faculty members at the University of North Carolina School of Dentistry, The Scripps Research Institute (TSRI) and other institutions have discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that target the cancer’s underlying genetic causes.
Feng Liu, PhD, a research professor in the Division of Molecular Pharmaceutics and UNC Lineberger member, died tragically Thursday, July 24, after being assaulted and robbed while walking in a neighborhood near campus. Liu was a dedicated colleague, educator and researcher focused on gene and drug delivery.
Hepatitis C virus (HCV) lingers in the human body for years, slowly damaging the liver and leading to liver diseases such as hepatitis, cirrhosis and liver cancer, which is often fatal. Research conducted at the University of North Carolina at Chapel Hill has discovered a mechanism that facilitates the virus achieving this life-long persistence. Chronic HCV infection is the leading cause of liver cancer in the United States.
UNC Hospitals is nationally ranked in cancer, taking the number 38th spot in the country. The latest ranking is up from 43rd in 2013.
Dr. Antonio (Tony) Amelio recently began his joint appointment as assistant professor in the Department of Dental Ecology at the UNC School of Dentistry and as associate member at UNC Lineberger.
Sharon Campbell, professor of biochemistry and biophysics, has been awarded the 2014 Hyman L. Battle Distinguished Cancer Research Award by the UNC School of Medicine. The award recognizes sustained, exceptional cancer research over a career by School of Medicine faculty.
The Bladder Cancer Advocacy Network (BCAN) has awarded William Kim, MD, associate professor of medicine, urology, and genetics, University of North Carolina at Chapel Hill and UNC Lineberger Comprehensive Cancer Center, with the 2014 Bladder Cancer Research Innovation Award to support his project “Immune Characterization of High-Grade Bladder Cancer.”
Six UNC Lineberger members are among the most often-cited scientists in the world, according to the Thomson Reuters 2014 Highly Cited Researchers list.
Cancer care in North Carolina is the focus of the July/August issue of the North Carolina Medical Journal (NCMJ). The issue, co-guest-edited by UNC Lineberger Comprehensive Cancer Center members Ethan Basch, MD, and Stephanie Wheeler, PhD, MPH, features articles on a wide variety of issues that determine how the state’s residents receive treatment for cancer.
Obesity, epidemic in the U.S. and worldwide, is one of the important modifiable risk factors for breast cancer, especially a particularly aggressive subtype called basal-like breast cancer (BBC). Population studies have suggested that lifestyle interventions, including weight loss, could prevent a large proportion of this type of cancer; however, data on the effect of weight loss on BBC risk are limited and the mechanisms involved uncertain.
Though cancer screening has come a long way, physicians still do not thoroughly discuss with patients the advantages and disadvantages of these procedures before decisions are made to undergo the screenings, according to a new study co-authored by a physician from The University of North Carolina at Chapel Hill’s Gillings School of Global Public Health.
The ability of researchers and physicians to use DNA sequencing to pinpoint the genetic mutations that cause cancer has led to greater understanding of the causes of the disease and development of drugs that treat tumors by targeting specific mutations. A pair of papers published by researchers at the UNC Lineberger Comprehensive Cancer Center reveal new tools that can improve the accuracy of tumor sequencing.
The American Society of Clinical Oncology (ASCO) has chosen Ronald Chen, MD, MPH, assistant professor of radiation oncology and member of the UNC Lineberger Comprehensive Cancer Center, as a member of the 2014-2015 ASCO Leadership Development Program.
A story that ran on Raleigh-based CBS affiliate WRAL focuses on a new bladder cancer vaccine being studied at UNC, called Impact Therapy. The vaccine works to target cancer cells with minimal side effects.
NEW YORK (Reuters Health) - When it comes to cancer screening, doctors often do not adequately discuss the balance of pros and cons with their patients, a new study suggests.
A delegation from the Tata Memorial Centre cancer hospital in Mumbai, India visited the UNC Lineberger Comprehensive Cancer Center as part of a U.S. tour visiting comprehensive cancer centers. The visit, sponsored through the National Cancer Institute’s (NCI) Liaison for International Partnerships, was intended to share knowledge about how American universities and hospitals operate a comprehensive cancer center.
Close to a dozen BB&T employees recently gave their morning to volunteer at the Patient and Family Resource Center (PFRC) at the N.C. Cancer Hospital. They came to deliver the BB&T “Comfort Cart,” a rolling cart filled with snacks to comfort and sustain cancer patients and their families while they are at the cancer hospital. They brought enough granola bars, nutrition shakes and other non-perishable snacks to keep the cart stocked for months. They also brought the gifts of housekeeping and organization.
The UNC/Rex team joined thousands of cancer survivors and supporters on Saturday, June 14th for the 18th annual Susan G. Komen Triangle Race for the Cure at Meredith College in Raleigh.
Noam Vanderwalde, MD, a radiation oncology resident at the N.C. Cancer Hospital, was awarded a 2014 Young Investigator Award by the Conquer Cancer Foundation of the American Society of Clinical Oncology (ASCO).
The discovery, from the lab of Brian Strahl, PhD, offers insights for the creation of better, more targeted therapies for various forms of cancer.
Physical activity after breast cancer diagnosis has been linked with prolonged survival and improved quality of life, but most participants in a large breast cancer study did not meet national physical activity guidelines after they were diagnosed.
Wheeler and Reeder-Hayes research shows African-American women and those insured by Medicaid less likely to receive endocrine therapy to prevent breast cancer recurrence
New research by Stephanie B. Wheeler, PhD; Katie Reeder-Hayes, MD; and Anne Marie Meyer, PhD, reveals that breast cancer patients insured by Medicaid and African-American breast cancer patients are less likely to receive life-saving endocrine therapy (ET) to prevent cancer recurrence.
More than 25 members and affiliated physicians of the UNC Lineberger Comprehensive Cancer Center will present their work to the attendees at the 2014 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, being held May 30 through June 3. The annual meeting brings together more than 25,000 oncology professionals to present research and discuss new treatment options.
CHAPEL HILL, NC - Why are some 75-year-olds downright spry while others can barely get around? Part of the explanation, according to research published today in Cell Press journal "Trends in Molecular Medicine," is differences from one person to the next in exposure to harmful substances in the environment, chemicals such as benzene, cigarette smoke, and even stress.
The UCRF, a $42 million, state-appropriated fund established in 2007, continues to have a significant impact on cancer research in North Carolina.
Virginia resident Marie Clem loves to hike. She began the activity as a way to improve her physical and mental health, and it has turned into so much more. On April 26, Marie, alongside family and friends, hiked for a different reason: to fight bone cancer.
An article on the benefits of exercise for breast cancer survivors recently published on the Runner's World website is based off of research published by UNC Lineberger member and Associate Professor of Exercise and Sport Science, Claudio Battaglini, PhD.