The protein GATA-3 plays an important role in mammalian immune response, but its overall function in cell development and cancer formation is not well understood. In an effort to further define the importance of GATA-3, researchers at the University of North Carolina have traced how the protein performs important functions in CD8+T-cell type of the immune system.
Intensity-modulated radiation therapy has become the most commonly used type of radiation in prostate cancer, but research from the University of North Carolina suggests that the therapy may not be more effective than older, less expensive forms of radiation therapy in patients who have had a prostatectomy.
Charles Perou, PhD, the May Goldman Shaw Distinguished Professor of Molecular Oncology, has been honored with the 2013 Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research. Dr. Perou is a member of UNC Lineberger Comprehensive Cancer Center.
University of North Carolina School of Medicine researchers uncover surprising insights about how nerve cells rewire themselves, shedding light on a process linked with neurodegenerative diseases and neurodevelopmental disorders like schizophrenia and autism.
Endeavors profiles the work of Nancy Klauber-DeMore, MD, professor of surgery and a member of UNC Lineberger, in unraveling the mystery of whether the gene SFRP2 suppresses tumor growth.
Barbara K. Rimer, DrPH, Dean and Alumni Distinguished Professor of the University of North Carolina Gillings School of Global Public Health, has been awarded the American Cancer Society (ACS) Medal of Honor for her "seminal cancer research efforts."
Claire Dees, MD, and Neil Hayes, MD, MPH, have been appointed as co-leaders of the Clinical Research Program at UNC Lineberger Comprehensive Cancer Center. Dr. Dees and Hayes have extensive and complementary expertise in translational and clinical research. As co-leaders of the Clinical Research Program, they will help plan the efforts of UNC Lineberger’s physician researchers to move discoveries into innovative trials of new therapeutic approaches.
Q&A with UNC Lineberger members James P. Evans, MD, PhD; David Ollila, MD; Paola Gehrig, MD; and Keith D. Amos, MD, FACS.
Jennifer Smith, PhD, MPH, research associate professor at the UNC Gillings School of Global Public Health and member of the UNC Lineberger Comprehensive Cancer Center, says that lack of awareness and stigma about the illness hinders prevention of the disease.
Patients must take a larger role in participating in and assisting in determining priorities for medical research, according to an editorial published in an upcoming issue of the Journal of the American Medical Association.
Hy Muss, MD, Director, Geriatric Oncology Program discusses evaluation tools for treating older patients on OncLive.
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
In Kenya, women face a cervical cancer mortality rate that is approximately 10 times as high as in the United States. A study by researchers at the University of North Carolina at Chapel Hill suggests that training women to self-collect genital samples to test for human papillomavirus (HPV), the causative agent of cervical cancer, can increase the coverage rates of cervical cancer screening. Higher screening coverage helps increase rates of detection of cervical lesions and ultimately treatment of the disease.
Raj Pruthi, MD, Chief of Urologic Surgery for the Urologic Oncology Program spoke at the annual meeting of the American Urological Association (AUA) in San Diego, California.
UNC women’s basketball Coach Sylvia Hatchell’s blueberry patch near Black Mountain, NC is getting ready for the summer picking season.
Close to 450 people attended the 37th annual UNC Lineberger scientific symposium April 29 and 30, 2013. Symposium co-chairs were Jonathan Serody, MD, PhD, Elizabeth Thomas Chair of Medicine, and Jenny Ting, PhD, UNC Alumni Distinguished Professor of Microbiology and Immunology. Both spoke at the symposium.
Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease. An international team, led by scientists at the University of North Carolina Lineberger Comprehensive Cancer Center, reports pre-clinical research showing improved efficacy of a PEGylated liposomal (encapsulated) anti-cancer agent compared with a non-liposomal formulation of the same drug in an intracranial model of breast cancer. Their results were published in the May 1, 2013 issue of PLOS ONE.
Associate professor Deborah Mayer, PhD, RN, AOCN, FAAN and member of UNC Lineberger has been selected as an Extraordinary Nurse Leader by Yale University, the first independent university-based nursing school established in the United States. As part of its 90th anniversary celebration, Yale School of Nursing has selected 90 alumni who “embody the School’s mission of advancing better health care” to be honored at a ceremony in October 2013.
Kurt Ribisl, PhD, head of Cancer Prevention and Control Program at the UNC Lineberger Comprehensive Cancer Center, was interviewed by National Public Radio on New York City's proposal to raise the legal age to buy cigarettes to 21.
A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.