We are in the Lineberger Comprehensive Cancer Center of the University of North Carolina, located in beautiful Chapel Hill.
Our team is a dynamic and enthusiastic group studying several different aspects in the field of cancer biology.
The dynamic process of cell growth and division is under constant surveillance. As one of the primary “gatekeepers” of the cell, the p53 tumor suppressor plays a major role in sensing a variety of stressors to maintain cellular homeostasis. Research in our laboratory focuses on delineating the biological function and molecular mechanism of the p53 tumor suppressor.
The broad goal of our lab is to uncover the complex regulatory network surrounding p53 tumor suppression pathway, thereby providing a possible means to manipulate p53 function. Postdoctoral fellows and graduate students will receive supervision in a multi-disciplinary program based on (but not limited to) the research outlined below that seeks to maximize trainees’ abilities to successfully perform novel and speculative experiments. We are currently focusing on three related research areas.