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C. Ryan Miller, MD, PhD, UNC Lineberger member and an associate professor in the UNC School of Medicine Department of Pathology and Laboratory Medicine, was senior author of a study published in Neuro-Oncology that examined how tumor-initiating mutations relate to molecular subtypes as gliomas progress from low-to-high-grade disease.

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C. Ryan Miller, MD, PhD, is a UNC Lineberger member and an associate professor in the UNC School of Medicine Department of Pathology and Laboratory Medicine.

For the study, UNC Lineberger researchers examined gene expression, copy number and other tumor features to study genomic changes that occur during the course of malignant progression from low- to high-grade disease in glioma, a tumor of the brain and spinal cord.

They report in the study that oncogenic driver mutations influence the genomic profiles of low-grade tumors and that these mutations, as well as progression-acquired mutations, “contribute strongly to the genomic heterogeneity across high-grade tumors.”

In addition to Miller, other authors include: Mark Vitucci, research collaborator in the UNC School of Medicine; David M. Irvin, a graduate student at the UNC School of Medicine; Robert S. McNeill, a graduate student in the UNC School of Medicine; Ralf S. Schmid, a research associate at the UNC School of Medicine and a member of UNC Lineberger; Jeremy M. Simon, research assistant professor in the UNC School of Medicine; Harshil D. Dhruv, a graduate student in the UNC School of Medicine; Marni B. Siegel, a graduate and medical student in the UNC School of Medicine; Andrea M. Werneke, a graduate student in the UNC School of Medicine; Ryan E. Bash, a research specialist at the UNC School of Medicine; Seungchan Kim, a graduate student in the UNC School of Medicine; and Michael E. Berens.