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Gary Pielak

Gary Pielak

  • Ph.D.
  • Molecular Therapeutics

  • Chemistry
  • UNC-Chapel Hill
  • gary_pielak@unc.edu
  • 966-3671
  • C748 Kenan

Area of Interest

We use the formalism of equilibrium thermodynamics and the tools of molecular biology and biophysics to understand how nature designs proteins. Our research focuses on several cancer
related proteins including apaf-1, a protein that is key to apoptosis, and natively disordered proteins, a new class of proteins whose members control cellular signaling and regulation. We bring to bear techniques such as random- and directed-mutagenesis, circular dichroism spectropolarimetry, differential scanning calorimetry, isothermal titration calorimetry, analytical ultracentrifugation, mass pectrometry, and nuclear magnetic resonance spectroscopy.

Awards and Honors

I was elected as the co-chair of the 2007 Proteins Gordon Research Conference and co-vice chair
of the 2005 Proteins Gordon Research Conference
Underhill Fund Award (BBSRC, U.K.)
Invited Speaker, Proteins Gordon Conference, 2001
Invited Speaker, Biopolymers Gordon Conference, 2002
Invited Speaker, RASMB Gordon Conference, 2002
Invited Speaker FASEB Meeting: Protein Folding in the Cell, 2002
Invited Speaker 13th Conversations in Biomolecularstereodynamics, 2003