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Toxicity of the anticancer drug CPT-11 is alleviated by inhibiting a specific enzyme (pictured in purple and blue) in human symbiotic gastrointestinal bacteria. Researchers identified compounds (yellow) that target and bind to the enzyme, blocking the reaction that leads to the drug's debilitating side effects. Credit: Bret D. Wallace and Matthew R. Redinbo, UNC-Chapel Hill.

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