Toxicity of the anticancer drug CPT-11
is alleviated by inhibiting a specific
enzyme (pictured in purple and blue) in
human symbiotic gastrointestinal bacteria.
Researchers identified compounds (yellow)
that target and bind to the enzyme,
blocking the reaction that leads to the
drug's debilitating side effects.
Credit: Bret D. Wallace and
Matthew R. Redinbo, UNC-Chapel Hill.