UNC Lineberger News

UNC scientists describe protein that protects against colon cancer

Chapel Hill - A family of proteins is yielding new information about how it contributes to the development of gastrointestinal disease and cancer. A team of UNC scientists reports that in pre-clinical models, the absence of a protein called NLRP12 significantly increases susceptibility to colitis-associated colon cancer.

UNC scientists describe protein that protects against colon cancer - Read More…

Three-dimensional RNA modeling opens scientific doors

Chapel Hill, NC – In a paper published today in the journal Nature Methods, a team from the University of North Carolina at Chapel Hill demonstrates a simple, cost-effective technique for three-dimensional RNA structure prediction that will help scientists understand the structures, and ultimately the functions, of the RNA molecules that dictate almost every aspect of human cell behavior. When cell behavior goes wrong, diseases – including cancer and metabolic disorders – can be the result.

Three-dimensional RNA modeling opens scientific doors - Read More…

UNC scientists describe protein that protects against colon cancer

Chapel Hill - A family of proteins is yielding new information about how it contributes to the development of gastrointestinal disease and cancer. A team of UNC scientists reports that in pre-clinical models, the absence of a protein called NLRP12 significantly increases susceptibility to colitis-associated colon cancer.

UNC scientists describe protein that protects against colon cancer - Read More…

Ten minutes could save your life: FREE Head & Neck Cancer Screenings

UNC Health Care will offer free screenings during Oral, Head and Neck Cancer Awareness Week, on Wednesday, April 25, from 1 - 4 p.m. in the Ear, Nose, & Throat Clinic on the ground floor of the N.C. Neurosciences Hospital.

Ten minutes could save your life: FREE Head & Neck Cancer Screenings - Read More…

Kinase test may yield big gains for drug-resistant cancers

Chapel Hill, NC – In a paper published today in the journal Cell, a team from the University of North Carolina at Chapel Hill unveils the first broad-based test for activation of protein kinases “en masse”, enabling measurement of the mechanism behind drug-resistant cancer and rational prediction of successful combination therapies.

Kinase test may yield big gains for drug-resistant cancers - Read More…

Gene switches do more than flip “on” or “off”

Gene switches do more than flip “on” or “off”

Chapel Hill - Anyone who’s tried a weekend home improvement project knows that to do a job right, you’ve got to have the right tools. For cells, these “tools” are proteins encoded by genes.

Gene switches do more than flip “on” or “off” - Read More…

Dr. Nancy DeMore and UNC colleagues present triple-negative breast cancer finding at national meeting

Nancy DeMore, MD, and colleagues presented an abstract at the recent Society of Surgical Oncology 65th annual cancer symposium held in Orlando, Florida in March. Dr. DeMore is an associate professor of surgery and a member of UNC Lineberger.

Dr. Nancy DeMore and UNC colleagues present triple-negative breast cancer finding at national meeting - Read More…

UNC’s Neuro-oncology program recognizes Ependymoma Awareness Day on April 19th

UNC Cancer Care’s neuro-oncology program will recognize Ependymoma Awareness Day on April 19th, as part of the program’s overall efforts to increase public awareness of this rare tumor and the need for clinical studies to improve early diagnosis, standardize treatment and improve the health status of those living with this disease.

UNC’s Neuro-oncology program recognizes Ependymoma Awareness Day on April 19th - Read More…

Evans quoted in The News & Observer, Scientific American Blog

Evans quoted in The News & Observer, Scientific American Blog

James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted in recent articles in The News & Observer and the Scientific American blog.

Evans quoted in The News & Observer, Scientific American Blog - Read More…

Clinical trial of experimental drug targeting mutation in thyroid cancer shows clinical benefit

Clinical trial of experimental drug targeting mutation in thyroid cancer shows clinical benefit

Chapel Hill - In a clinical trial of an experimental drug to treat thyroid cancer, UNC and six other institutions report the first evidence in this tumor that targeting therapy to an oncogene documented to be present in the patient receiving therapy may be associated with clinical benefit.

Clinical trial of experimental drug targeting mutation in thyroid cancer shows clinical benefit - Read More…

Sharpless, Zanation honored as Health Care Heroes

Sharpless, Zanation honored as Health Care Heroes

UNC Lineberger faculty members Ned Sharpless, MD, and Adam Zanation, MD, were honored for their achievements by Triangle Business Journal as 2012 Health Care Heroes.

Sharpless, Zanation honored as Health Care Heroes - Read More…

Ollila, Burkhart talk about teenage tanning bed use

Ollila, Burkhart talk about teenage tanning bed use

David Ollila, MD, and Craig Burkhart, MD, spoke about teenage tanning bed use at a Child Fatality Task Force committee meeting on March 26, 2012. They discussed the option of banning teenagers below the age of 18 from tanning bed use.

Ollila, Burkhart talk about teenage tanning bed use - Read More…

UNC Lineberger scientist receives grant for pancreatic cancer research

UNC Lineberger scientist receives grant for pancreatic cancer research

The Lustgarten Foundation, the nation’s largest foundation dedicated solely to funding pancreatic cancer research, has awarded Channing Der, PhD, a $1.165 million grant to identify promising drug combinations for potential future use in clinical trials.

UNC Lineberger scientist receives grant for pancreatic cancer research - Read More…

Aspirin use may offer cancer prevention benefits, Baron dicusses on MedPage Today

John Baron, MD, was interviewed by Charles Bankhead of MedPage Today on March 21, 2012 to give his perspective on three recently published reviews in "The Lancet" and "The Lancet Oncology." The reviews suggest that "regular aspirin use leads to significant reductions in the risk of cancer, metastasis, and cancer mortality."

Aspirin use may offer cancer prevention benefits, Baron dicusses on MedPage Today - Read More…

Predictive biomarkers for lung cancer reported in laboratory finding

Predictive biomarkers for lung cancer reported in laboratory finding

A team of scientists, including several from UNC Lineberger, has identified predictive genetic biomarkers in pre-clinical models that affect response to therapy for non-small cell lung cancer (NSCLC). The study was done in parallel to an ongoing clinical trial among lung cancer patients at multiple institutions.

Predictive biomarkers for lung cancer reported in laboratory finding - Read More…

Lung cancer highlights from 2011, Weiss provides insight

Lung cancer highlights from 2011, Weiss provides insight

Jared Weiss, MD, gave a podcast titled "2011 Highlights in Lung Cancer" that was posted on cancergrace.org on March 15, 2012. In the podcast, Dr. Weiss talks about highlights in lung cancer from 2011 and also answers questions.

Lung cancer highlights from 2011, Weiss provides insight - Read More…

Joseph Pagano: still going “80 mph”

Joseph Pagano: still going “80 mph”

Internationally renowned virologist; past president of national cancer and international virology associations; National Academy of Science Institute of Medicine member; North Carolina Award for Science winner; revered mentor to faculty, fellows, medical and graduate students; Berryhill Lecturer; proud grandfather; dedicated squash and tennis player; and recent honoree at his eightieth birthday.

Joseph Pagano: still going “80 mph” - Read More…

real doctors, real people - N.E.D.

real doctors, real people - N.E.D.

N.E.D. is a rock band. The members of the band are gynecologic cancer surgeons from all over the country and two of them, Dr. John Boggess and Dr. John Soper, work here at UNC Health Care.

real doctors, real people - N.E.D. - Read More…

UNC researchers: Benefits of varenicline (Chantix) may balance certain risks

Drs. Christine E. Kistler and Adam Goldstein discuss how clinicians can better have conversations about the balance between short-term risk of adverse cardiovascular events associated with taking Chantix compared to the long-term reduction in the risk of death that results from smoking cessation.

UNC researchers: Benefits of varenicline (Chantix) may balance certain risks - Read More…

Hiding emotions may exacerbate depression among black men who confront racial discrimination

Hiding emotions may exacerbate depression among black men who confront racial discrimination

Enduring subtle, insidious acts of racial discrimination is enough to depress anyone, but African-American men who believe that they should respond to stress with stoicism and emotional control experience more depression symptoms, according to new findings from the University of North Carolina at Chapel Hill.

Hiding emotions may exacerbate depression among black men who confront racial discrimination - Read More…

UNC study identifies pockets of high cervical cancer rates in North Carolina

A study of cervical cancer incidence and mortality in North Carolina has revealed areas where rates are unusually high.

UNC study identifies pockets of high cervical cancer rates in North Carolina - Read More…

UNC research center receives contract to fight kidney cancer

UNC research center receives contract to fight kidney cancer

The Center for Integrative Chemical Biology and Drug Discovery at the University of North Carolina at Chapel Hill has received a contract from SAIC-Frederick, Inc. to develop potential drug leads for treating renal cell carcinoma, the most common type of kidney cancer in adults.

UNC research center receives contract to fight kidney cancer - Read More…

Small DNA circles found outside the chromosomes in mammalian cells and tissues, including human cells

CHAPEL HILL, N.C. – Researchers from the University of North Carolina at Chapel Hill have helped identify a new DNA entity in mammalian cells and provided evidence that their generation leaves behind deletions in different locations of the cells’ genetic program, or genome.

Small DNA circles found outside the chromosomes in mammalian cells and tissues, including human cells - Read More…