UNC Lineberger at the American Association for Cancer Research Annual Meeting

UNC Lineberger was well represented at the American Association for Cancer Research Annual Meeting held in Washington, DC.

Speakers included:

  • Chuck Perou, PhD, May Goldman Shaw Distinguished Professor of Molecular Oncology, gave a plenary talk on “The therapeutic implications of genome sequencing and expression analyses for breast cancer” and a second talk on “The implications of genome sequencing for clinical trial design.”
  • Neil Hayes, MD, MPH, associate professor of medicine, took part in a media briefing and gave a talk: “Comprehensive genomic characterization of squamous cell carcinoma of the head and neck in the Cancer Genome Atlas.”
  • Katie Hoadley, PhD, gave two talks: “RNA sequencing for analyzing expression of genes and isoforms” and “Multi-tumor analysis of TCGA data identifies expression commonalities across tumor types.”
  • Gary Johnson, PhD, Kenan Distinguished Professor and Chair of Pharmacology, spoke on “Breast cancer subtypes have selective kinome reprogramming in response to kinase inhibitors.”
  • Scott Magness, PhD, assistant professor of medicine, spoke on “Stem cells, enteroids, and organoids: A new era for in vitro models of the intestine.”
  • Angelique Whitehurst, PhD, gave a talk as part of a special Stand Up 2 Cancer session "An eye towards translation" – Her talk was titled "Framing therapeutic opportunities in tumor-activated gametogenic programs.”

Poster sessions participants:

  • Ruth Everett, PhD, research assistant professor, UNC Eshelman School of Pharmacy - Thakker lab: “Multiple cation-selective transporters contribute to the anti-proliferative effects of metformin in ovarian cancer cell lines.”
  • Peggy Gulley, MD, professor of pathology: “Case-case comparison of smoking and alcohol risk associations with Epstein-Barr virus-positive gastric cancer.”
  • Qiu Haifeng, MD - Bae-Jump lab: “JQ-1, a novel c-Myc inhibitor, suppressed cell proliferation and metabolism through the downregulation of lactate dehydrogenase A in ovarian cancer cells.”
  • Lara Haydee, PhD, postdoctoral research associate - Andrew Wang lab: "Nanoparticle formulation of KU55933 as a potent radiosensitizer"
  • Amanda Jackson, MD - Bae-Jump lab: “Antitumorigenic effects of phenformin in human ovarian cancer cell lines.”
  • Joshua Kilgore, MD - Bae-Jump lab: “The effects of NT1014, a novel AMPK activator, on ovarian cancer cell proliferation and apoptosis.”
  • Andrew Madden, PharmD - Zamboni lab: “Evaluation of the efficiency of tumor and tissue delivery of carrier mediated agents (CMA) and small molecule (SM) agents in mice using a novel pharmacokinetic (PK) metric relative distribution index over time (RDI-OT).”
  • Jun Nakamura, PhD, DVM, Xu Tian – Swenberg lab: “REV1 has critical roles in base excision repair intermediate-mediated transversion mutations but not for O6-methylguanine-initiated mutations in vertebrate cells” and “POLD3 is required for DNA damage response to endogenous and exogenous DNA damage in human cells.”
  • Ryan Phillips, PhD candidate - Allbritton lab: "A novel approach to the measurement of tyrosine phosphorylation dynamics in intact single cells using capillary electrophoresis."
  • Gina Song, PharmD - Zamboni's lab: "Relationship between tumor-associated macrophages (TAMs), tumor delivery, and efficacy of PEGylated liposomal doxorubicin (PLD) and non-liposomal doxorubicin (NL-doxo) in genetically engineered mouse models (GEMMs) of breast cancer (BC)."
  • Edina Wang, BS - Andrew Wang lab: "Differential cellular response to nanoparticle docetaxel and docetaxel at sub-therapeutic dose range."
  • Sara Wobker, MD, MPH - Bae-Jump lab: “Nuclear homeoprotein SIX1 is associated with stage and grade of endometrial carcinoma.”
  • Chunxiao Zhou, MD, PhD - Bae Jump lab: “Dual targeting of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Using NVP-BEZ235 suppressed tumor growth in a genetically engineered mouse model of serous ovarian cancer.”

Special Sessions Participants:

  • Channing Der, PhD, Sarah Graham Kenan Professor of Pharmacology - Pancreatic Cancer Action Network-AACR Research Grants Poster Presentation and Discussion and co-led a session on “Basic and translational research career paths in pancreatic cancer.”
  • Buddy Weissman, PhD, served as a mock study session chairperson for a Grant Writing Workshop

AACR Award Winner:

UNC junior Patrick Short, a student in the lab of Dr. Joseph DeSimone, won a Bardos Science Education Award to participate in the AACR annual meeting for two years. The award encourages promising young students to pursue cancer research in their careers.

The Morehead-Cain Scholar, an applied mathematics and quantitative biology major, was recently named a Goldwater Scholar. The scholarship provides up to $7,500 per year for educational expenses to sophomores and juniors who intend to pursue careers in mathematics, the natural sciences or engineering.

He says, “ The opportunity to attend the AACR Annual Meeting as a part of the Thomas J. Bardos Award is a really incredible opportunity to get first-hand exposure to the latest advances in cancer research. In particular, the program of events is incredibly multi-dimensional, offering the opportunity to learn about cancer research from the perspective of pharmaceutical development, advances in personalized medicine, and tumor immunology and immunotherapy, just to name a few. Going forward, I hope to pursue an MD-PhD with a focus in computational genetics. I am particularly interested in personalized medicine and the use of high throughput technologies and large-scale data analysis for a wide variety of medical applications including cancer research and preventive care. I have no doubt that the Thomas J. Bardos Award and the opportunity to attend the AACR annual meeting will have a deep impact on my research career going forward.”