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The grant will be used to further research to globally understand regulated protein degradation and how this contributes to normal cellular functions that are dysfunctional in cancer.

Michael Emanuele, PhD, assistant professor of pharmacology, has received a V Scholar Award from the V Foundation for Cancer Research. Dr. Emanuele is one of 18 recipients in the United States to receive the two-year $200,000 award.

Dr. Emanuele will use the grant to further his research to globally understand regulated protein degradation and how this contributes to normal cellular functions that are dysfunctional in cancer. He will work to develop and apply genetic and proteomic screening methods to define the ubiquitin protein’s signaling networks that respond to cellular damage, thus identifying signaling system components that serve as high-priority candidates for small-molecule inhibitor development to combat cancer.

Dr. Emanuele, a member of UNC Lineberger Comprehensive Cancer Center, joined the UNC faculty in 2013.

The V Foundation was founded in 1993 by ESPN and the late Jim Valvano, legendary NC State basketball coach and ESPN commentator. In its 20 years, The V Foundation has awarded more than $100 million for research into all types of cancer to more than 100 institutions in 38 states and the District of Columbia.