UNC Lineberger researchers Hy Muss, MD, Shlomit Strulov Shachar, MD, and colleagues report in the journal Clinical Cancer Research that a measure of muscle mass and muscle quality developed at UNC could potentially help doctors better identify patients at high risk for side effects that could require hospitalization.
With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.
A study led by UNC Lineberger researcher Ronald Chen, MD, found that a group of prostate cancer patients reliably reported their own medical histories when their responses were compared to their medical records.
UNC Lineberger's Marilie D. Gammon, PhD, and Humberto Parada, PhD, report in JNCI: The Journal of the National Cancer Institute that breast cancer patients who ate barbecued, grilled and smoked meats at higher annual amounts in the decade before their diagnosis had a greater risk of death from any cause.
UNC Lineberger's Shawn Hingtgen, PhD, and colleagues, in laboratory studies, have converted human skin cells into stem cells that can hunt down and kill human brain cancer, an important step to moving the approach closer to a clinical trial.
Thanks to the donation of handmade scarves from community groups, UNC Lineberger’s Patient and Family Resource Center staff are helping women to counter some of the side effects of cancer treatments. In addition to receiving a beautiful scarf, the women were taught different ways to wear it.
UNC Lineberger researchers Ethan Basch, MD, MSc, and Stephanie Wheeler, PhD, MPH, called for tailored, local-level cancer prevention, screening and treatment efforts to address regional disparities in cancer mortality rates in an editorial published in the Journal of the American Medical Association.
In the journal Cancer Discovery, UNC Lineberger's Gary Johnson, PhD, and colleagues published findings on how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved kinase inhibitor. They also demonstrated in a laboratory model a potential treatment approach that could prevent the onset of resistance.
A team of researchers, including UNC Lineberger's Norman E. Sharpless, MD, has shown that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. Eliminating the senescent cells in mice prevented the side effects and relapse.
Backed by a three-year, more than $1.8 million grant from the National Cancer Institute, UNC Lineberger researchers Ryan Miller, MD, PhD, and Gary Johnson, PhD, plan to develop better cancer models to identify patterns of drug resistance in glioblastoma.
In a perspective published in the New England Journal of Medicine, UNC Lineberger member Ethan Basch, MD, MSc, addressed the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits.
UNC Lineberger member and Nobel Laureate Oliver Smithies, DPhil, passed away Jan. 10. UNC Lineberger Director Norman E. Sharpless, MD, said Smithies "played a critical role in the university’s evolution into a world-leading scientific juggernaut."
Scientists at the University of North Carolina at Chapel Hill have developed a method to control proteins inside live cells with the flick of a switch, giving researchers an unprecedented tool for pinpointing the causes of disease using the simplest of tools: light.
A start-up company co-founded by UNC Lineberger researcher Andrew Wang, MD, has raised $2.9 million to commercialize a test designed to capture cancer cells circulating in the blood.
Scientists led by UNC Lineberger member John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.
In a study presented at the American Society of Hematology Annual Meeting in San Diego, Catherine C. Coombs, MD, MS, and colleagues reported that nearly a quarter of patients heavily treated for other cancers had mutations in their white blood cells, and that the majority of those mutations were leukemia-linked.
Researchers and clinicians attended the 2016 UNC-Duke Viral Oncology & AIDS Malignancy Symposium on Dec. 14 to hear presentations and share their perspectives on the latest efforts to prevent and treat cancers linked to infectious agents.
Less than 50 percent of surveyed teens found it ‘very believable’ that cigars are not a safe alternative to cigarettes, according to a first-of-its-kind study led by a UNC Lineberger researcher.
The University of North Carolina Lineberger Comprehensive Cancer Center Geriatric Research Symposium, held Dec. 2, featured seven presentations and panel discussions focused on muscle mass, aging and patient function.
UNC Lineberger breast cancer faculty members presented their research findings at the 2016 San Antonio Breast Cancer Symposium Dec. 6-10. The meeting drew more than 7,000 cancer caregivers and scientists from around the world, who attended talks and presentations on the latest developments in breast cancer care and research.
UNC Lineberger researchers reported at the San Antonio Breast Cancer Symposium they have identified biomarkers they believe can be used as part of a larger model to predict how patients with HER2-positive operative breast cancer will respond to the targeted treatment trastuzumab, commercially known as Herceptin, and chemotherapy.
At this year's San Antonio Breast Cancer Symposium, UNC Lineberger researchers and collaborators shared the outcomes of their investigation into the incidence of brain metastasis after a series of drugs were approved to treat HER2-positive metastatic breast cancer, starting with trastuzumab, also known as Herceptin, in the United States in 1998.
In a study presented at the 2016 San Antonio Breast Cancer Symposium, UNC Lineberger researchers led by Katherine Hoadley, PhD, reported they developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy.
In preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers showed that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing results.
UNC Lineberger member Nancy Thomas, MD, PhD, has been named chair of the Department of Dermatology, effective Jan. 1.
Balancing medical needs with the desire to have a “normal” holiday can be challenging when someone is experiencing health issues, but the Patient and Family Resource Center staff at the N.C. Cancer Hospital and UNC Lineberger Comprehensive Cancer Center have found that patients and their families who discuss and prioritize what traditions matter most are able to focus more on celebrating – and less on stressing over – the holidays.
Matt Ewend, MD, FACS, has been named President of UNC Physicians. In this role, Ewend will oversee the physician clinical enterprise of UNC Health Care, which includes more than 2,400 physicians and 600 Advanced Practice Providers in 450 practices spanning the UNC Physicians Network, UNC Faculty Physicians, and physician practices at UNC Health Care affiliate hospitals.
Mia Hamm and the Mia Hamm Foundation are partnering with UNC Lineberger today, Tuesday, Nov. 29, to provide support for bone marrow transplant patients -- and their families -- and to help them address some of the challenges they may face while undergoing treatment.
Hospital staff and volunteers hosted a Thanksgiving lunch on Friday, Nov. 18, for 150 patients and their caregivers. The annual lunch, provided by UNC Hospital Catering, featured a traditional holiday meal -- replete with turkey, mashed potatoes, stuffing and cranberry sauce -- live music, and a caricature artist.
The American Association for the Advancement of Science, the world’s largest general scientific society and publisher of the journal Science, announced the election of Michael R. Kosork, PhD, as a fellow. Kosork is being honored for his distinguished contributions to biostatistics, in survival analysis, empirical processes and semiparametric models, statistical learning theory and personalized medicine, and for extraordinary administrative service.
UNC Lineberger researchers led by Adam Goldstein, MD, MPH, concluded in a study published in Tobacco Control that banning non-menthol flavors like fruit and candy could reduce use of most tobacco products across the globe, especially among adolescents.
Volunteers collected more than 3,300 items through word of mouth, churches, social media and other organizations in eastern North Carolina for Hats for Hope, the Annual Charli’ Ramsey Hat Drive, and delivered them to adult and pediatric patients at UNC Hospitals.
UNC Lineberger's Carrie Lee, MD, MPH, is chair-elect of the Association of American Cancer Institute’s Clinical Research Initiative Steering Committee, which is responsible for developing better methods to disseminate information across cancer centers, identifying and addressing clinical research challenges, and measuring progress on behalf of AACI.
Ian J. Davis, MD, PhD, and colleagues published a paper in Cell Reports that found certain short, repetitive sequences of DNA play an important role in the development of Ewing sarcoma, a rare bone and soft tissue cancer that occurs most commonly in children and adolescents.
UNC Lineberger researchers led by Timothy R. Gershon, MD, PhD, reported preclinical findings in the journal Development that show promise for targeting a gene linked to microcephaly in infants as a treatment for medulloblastoma.
Uninsured women under age 65 who received their mammogram at community screening clinics in North Carolina were less likely to get follow-up within a year of a positive mammogram, and had higher odds of missing a 60-day window for follow-up care, according to a study Louise Henderson, PhD, and her colleagues published in Cancer Epidemiology, Biomarkers & Prevention.
Andrew Olshan, PhD, and colleagues reported in Nature Genetics that immune system-related genetic variation may provide new insight into the mechanisms of protection against human papillomavirus-associated head and neck cancer.
North Carolina Cancer Hospital's Tony Williams Lobby was filled with friends, family and colleagues to celebrate Deborah Ballard, RN, MSN, ANP-C, OCN, Kristi Geib, RN, MSN, CPNP, CPON, Pearl Langhorne, and Jennifer Spring, RD, CSO, LDN, who received 2016 Oncology Excellence Awards.
More than 120 doctoral students, postdoctoral researchers and faculty members came together Oct. 18 to learn about research advances made by UNC Lineberger’s postdocs at the annual UNC Lineberger Postdoc Faculty Research Day. The day-long event included a poster competition for doctoral students and postdoctoral fellows, and an oral presentation competition.
The V Foundation for Cancer Research and Lung Cancer Initiative of North Carolina, as well as the Lung Cancer Research Foundation, awarded grants to support UNC Lineberger member Chad Pecot's lung cancer research.
In a recent study, UNC Lineberger researchers evaluated the feasibility and efficacy of two six-month, self-regulation interventions that focused on daily self-weighing, objective monitoring and tailored feedback in an effort to prevent weight gain among African-American breast cancer survivors.
For more than three decades, playwriting has been a hobby for UNC Lineberger researcher Keith Burridge, PhD. Burridge's play “The First Woman President” will be performed at a theater festival in New York City. The play will premiere Nov. 5 at the Midtown International Theatre Festival.
CBS's "60 Minutes" came to UNC Lineberger to learn how researchers are using IBM Watson to cull through and generate useful clinical insights from massive amounts of genetic data.
Susan G. Komen announced UNC Lineberger researcher Charles M. Perou, PhD, as the recipient of this year's Brinker Award for Scientific Distinction in Basic Science for his contributions to the understanding of breast cancer as distinct molecular subtypes that have prognostic value using cutting-edge cancer genomics tools.
With a focus on stem cells, Jeremy Purvis, PhD, wants to tap the power of computer modeling to develop regenerative medicine solutions to medical conditions.
North Carolina men’s basketball coach Roy Williams’ much beloved event has now raised more than $2.2 million over the years for UNC Lineberger Comprehensive Cancer Center, and the total will continue to grow, thanks to an online auction that is running through Oct. 17.
In the study published in the Journal of Clinical Oncology, UNC Lineberger researchers report that nearly a third of a group of patients with chronic myeloid leukemia, and who have federally-funded Medicare health insurance, did not start treatment within six months of diagnosis with any of three targeted drugs that have led to dramatic improvements in survival for the disease.
Among parents who reported that they were disinclined to vaccinate, UNC Lineberger researchers found in a recent study that the most convincing messages about the HPV vaccine were those that focused on the parent’s role in preventing the child from getting HPV-related cancers and those that emphasized their role in whether their child becomes infected with HPV.
In an analysis of survival data for a population of patients with a particular type of head and neck cancer, UNC Lineberger researchers confirmed that a particular strain of HPV, a virus linked to multiple cancers, resulted in better overall survival for patients with oropharyngeal cancer than patients with other strains of the virus.
American Association for Cancer Research, which is advocating for a $2 billion increase to the National Institutes of Health budget, expects more than 300 scientists, health professionals and patient advocates to be at this year’s Rally for Medical Research in Washington, D.C.
Barbara Savoldo, MD, PhD, will use the $250,000 Hyundai Scholar Grant to help fund her research of a new generation chimeric antigen receptor-based cell therapy for neuroblastoma.
A UNC Lineberger study published in the journal Breast Cancer Research and Treatment drew upon surveys that assessed health-related quality of life issues for women aged 20 to 74 years who lived in North Carolina and had breast cancer. The analysis was part of the third phase of the Carolina Breast Cancer Study.
Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.
Susan G. Komen has announced more than $2.5 million in grants for UNC Lineberger Comprehensive Cancer Center researchers. The organization, which funded eight grants for nearly $2.97 million to researchers in North Carolina, has a goal of reducing breast cancer deaths in the U.S. by 50 percent across the next decade.
Andrew Z. Wang, MD, a UNC Lineberger member and associate professor in the UNC School of Medicine Department of Radiation Oncology, received an award from the U.S. Army Medical Research Acquisition Activity to study a potential mechanism for improving immunotherapy for metastatic melanoma in the lungs.
UNC Lineberger's 2016 Annual Scientific Retreat included a juried poster presentation with work presented by postdoctoral researchers, trainees and students.
UNC Lineberger Director Norman Sharpless, MD, delivered the address as part of UNC Lineberger’s 2016 Annual Scientific Retreat, held Sept. 9 at the Carolina Club.
Thirteen research teams will receive grants through the spring 2016 cycle of the UNC Lineberger Developmental Grants program. The deadline for applying for the next round of funding is 5 p.m. Thursday, Sept. 15.
NIH Precision Medicine Initiative Cohort Research Program appoints Chung to Institutional Review Board
UNC Lineberger's Arlene Chung, MD, MHA, MMCi, will serve as an inaugural member of the NIH Precision Medicine Initiative Cohort Program Institutional Review Board.
Researchers led by UNC Lineberger Director Norman Sharpless, MD, and William Wood, MD, uncovered clues that suggest that stem cell transplant is linked to a marked increase in the “molecular age” of these immune cells in a group of patients with blood cancer.
In a paper published online by the Journal of the American Medical Association, UNC Lineberger physician-researchers led by Ethan Basch, MD, MSc, raised concerns that there are inconsistencies between the five reference guides, or compendia, that the Centers for Medicare and Medicaid Services uses to determine which drugs it will reimburse for off-label uses in cancer care.
UNC Lineberger researchers, led by Aaron Mitchell, MD, found a high prevalence of financial relationships among authors who helped develop a leading set of cancer care guidelines in the United States in a study published in JAMA Oncology. They say the work lays the foundation for future studies of whether the payments influenced clinical practice or guideline recommendations.
Findings published in the Journal of the National Cancer Institute show that immune cells do not respond the same way to all tumor types. The study, led by UNC Lineberger researcher Benjamin Vincent, MD, could lay the foundation for the discovery of biomarkers to determine which patients might respond to certain immune-stimulating cancer treatments.
A national survey found that parents were more likely to agree that laws requiring students to be vaccinated against HPV for school entry are a “good idea” when there is an opt-out clause.
UNC Lineberger Comprehensive Cancer Center Director Norman E. Sharpless, MD, has won election to the Association of American Cancer Institutes’ Board of Directors.
UNC Lineberger researcher Carey Anders, MD, wants to understand why some breast cancers metastasize to the brain, and what drives them. She recently was awarded a three-year, $450,000 grant to study genetic features of breast cancer brain metastases to try to answer those questions.
Before heading to the beach or the pool to cool down this summer, UNC Lineberger's Puneet Jolly reminds people to be mindful of their sun exposure and offers some simple sun safety tips.
In the analysis published in the journal Social Science & Medicine, researchers led by UNC Lineberger's Seth Noar found that cigarette smokers tried to quit more and smoked less overall when countries implemented new policies replacing text warnings with graphic images on cigarette packs or strengthened pack warnings in other ways.
A potentially life-saving breast cancer treatment was part of the care plan for one Orange County woman, but UNC Lineberger researchers have found gaps in how the treatment is used nationwide.
The N.C. Cancer Hospital, clinical home of UNC Lineberger Comprehensive Cancer Center, continues to climb higher in U.S. News’ Best Hospitals rankings.
UNC Lineberger researchers led by Cyrus Vaziri, PhD, describe the discovery of how a specific cellular protein present in cancer cells triggers a repair mechanism that allows them to DNA damage tolerance and abnormal growth.
Ethan Basch, MD, MSc, will use a five-year, $5.45 million grant from the Patient-Centered Outcomes Research Institute to support his national study on whether having cancer patients self-report their symptoms while undergoing treatment results in better care.
Brain radiation prolongs life for patients with cancer, but can cause serious side effects like memory delays or verbal impairments. In an editorial published Tuesday in the Journal of the American Medical Association, UNC Lineberger researchers say a new study has resolved a debate about the optimal treatment for patients with one to three brain metastases, finding “little role” for whole brain radiation.
Researchers say breast reconstruction can help with self-esteem, sexuality and body image after cancer treatment. But a UNC Lineberger study led by Michelle Roughton, MD, has found that the type of insurance a woman has as well as distance to a plastic surgeon's office can be barriers to the procedure.
When Beth Silverstein tested positive for the BRCA1 gene mutation, she knew she had to make some tough decisions about her health. But she wasn't alone. Her faith, her family and her multi-disciplinary health care team at UNC Lineberger were with her every step of the way.
Rebecca Williams, MHS, PhD, has studied the online sales of cigarettes and other tobacco products for nearly two decades. Through her research, including a recent paper in Tobacco Control, she has uncovered the ways the industry has gotten around government oversight, especially as it applies to sales to minors.
In 1975, UNC Lineberger was named a ‘Designated Cancer Center’ by the prestigious National Cancer Institute, a title that signifies we are an organization delivering high-level cancer care to patients throughout our community, state and nation. Most NCI-Designated Cancer Centers are affiliated with university medical centers, although several are freestanding centers that engage only in cancer research.
Breast cancer was not a death sentence for Malawi native Maggie Zgambo. She survived cancer despite financial and other obstacles. She believes that her life was spared for a reason: to spread awareness. Maggie was one of four women to take part in the first breast cancer screening pilot study in Malawi launched by UNC Lineberger Comprehensive Cancer Center researchers and physicians.
UNC Lineberger researchers led by Andrew Wang, MD, report in the International Journal of Radiation Oncology Biology Physics results from a study of using radiation to activate a new formulation of the drug mitomycin-C in colorectal cancer models.
UNC Lineberger researcher Adam O. Goldstein, MD, MPH, and UNC Department of Family Medicine researcher Clare Meernik, MPH, write in a commentary published in the Annals of Family Medicine that existing treatments are more effective than e-cigarettes to help people quit smoking, there are professional ethics concerns about providers who recommend them and there is no strong evidence that e-cigarettes are safe.
A leading expert in the molecular epidemiology of cancers of the head and neck and evaluation of risk factors for childhood cancer, Andrew Olshan, PhD, will serve as president-elect until next July, when he becomes president of the Society for Epidemiologic Research.
UNC Lineberger researcher Blossom Damania, PhD, has built her research career tackling difficult questions in cancer and global health research. As she begins her new role as UNC School of Medicine vice dean for research, she’s considering one more: What’s next?
The North Carolina Oncology Navigator Association’s annual meeting in Chapel Hill brought together nurses, patient navigators and community health workers to focus on building connections between health systems and communities for the patient’s benefit, said UNC Lineberger’s Jean Sellers, RN, MSN, the association’s president.
A study led by UNC Lineberger member Shawn Hingtgen, PhD, has determined that removing a glioblastoma tumor from the brain causes any cancer left behind to grow much faster than the original tumor did. The findings from the Neuro-Oncology paper illustrate the effect of surgery on the brain and tumor and the need to rethink how to treat the disease differently after the surgery.
Members from North Carolina’s three National Cancer Institute-designated comprehensive cancer centers, together with care providers, researchers, advocates and patients from the state, met in Chapel Hill to be part of a national discussion on how to speed the pace of cancer discovery and clinical advances.
UNC Lineberger researchers led by Dr. William A. Wood found that for patients treated in a hospital, the risk of death from acute myeloid leukemia was elevated in three regions of the state compared to a benchmark.
UNC Lineberger researcher Blossom Damania, PhD, postdoctoral researcher Aadra Bhatt, PhD, and colleagues have discovered a slick trick a virus uses to spur cancerous cell growth in its host: the virus initiates a signal that mimics one of the host cell’s own signals.
A study by UNC Lineberger researcher G. Greg Wang, PhD, and colleagues uncovered the genetic mechanism behind how acute myeloid leukemia cells with a specific DNA mutation stay as undifferentiated cells, rather than maturing into healthy blood cells.
A study led by UNC Lineberger researchers determined that black women with advanced breast cancer were less likely to receive supportive care medications, like antidepressants and sleep aids, than white patients. They also were less likely to enroll in hospice care, and more likely to get intensive treatment at the end of their lives.
UNC Lineberger member Stacie Dusetzina, PhD, a researcher who investigates drug pricing and insurance policy issues, will present today to the President’s Cancer Panel, and advisory group to president.
University of North Carolina Lineberger Comprehensive Cancer Center researchers were in Chicago June 3-7 for the American Society of Clinical Oncology (ASCO) Annual Meeting.
A national health claims analysis of cancer patients who were younger than age 65 and had metastatic disease revealed that nearly two-thirds were admitted to the hospital or visited the emergency room in the last 30 days of their lives. The UNC Lineberger researchers, who presented the study outcomes at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago, also found that nearly a third of patients died in the hospital.
Noel T. Brewer, PhD, and his UNC Lineberger colleagues report in JAMA Internal Medicine findings from their study that demonstrated that attaching graphic warning images to cigarette packs increased smokers' attempts to quit.
In a preliminary finding presented at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago, UNC Lineberger researchers Wendy Brewster, MD, PhD, and Temitope Keku, PhD, revealed they have found bacteria in the ovaries and fallopian tubes. Researchers also uncovered a trend toward a distinct bacterial profile in women with ovarian cancer.
More than one-in-four cancer patients had to pay more for medical care than they could afford, according to a study led by UNC Lineberger researchers. A reported 18 percent were unable to afford their prescription medications. The findings were presented at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago.
UNC Lineberger member Lisa A. Carey, MD, has been appointed co-chair of the Alliance for Clinical Trials in Oncology Breast Committee. The national organization is responsible for developing new trials, ensuring each project’s scientific excellence, operational efficiency and productivity, and promoting collaboration with other NCI-funded clinical trials groups.
Researchers from the University of North Carolina at Chapel Hill, including UNC Lineberger member Adam Goldstein, MD, MPH, and East Carolina University reported in the American Journal of Preventive Medicine that in all nine regions of the country, a majority of adults supported increasing the minimum legal age for tobacco product sales. They also found the most support for increasing the minimum age to 21 rather than to 20 or 19.
Nobel Prize winner Aziz Sancar, MD, PhD, a UNC Lineberger member and the Sarah Graham Kenan Professor of Biochemistry and Biophysics at the UNC School of Medicine was one of two distinguished professors to receive the O. Max Gardner Award, the highest faculty honor of the UNC Board of Governors.
UNC Lineberger researcher to study cervical cancer screening tool through Grand Challenges Explorations Grant
UNC Lineberger member Jennifer S. Smith, PhD, MPH, director of the Cervical Cancer-Free Coalition at the UNC Gillings School of Global Public Health and associate professor of epidemiology, will pursue an innovative global health and development research project to determine the effectiveness of a urine-based, cervical cancer screening tool under a Grand Challenges Exploration Grant, which is funded by the Bill & Melinda Gates Foundation.
In the journal npj Breast Cancer, researchers led by UNC Lineberger member Melissa Troester, PhD, reported they identified a particular gene expression pattern in normal-appearing breast tissue around tumors that was linked to lower 10-year survival rates for women with estrogen receptor-positive breast cancer.
More than 150 hair care professionals and health care providers from across North Carolina came together virtually for a webinar to discuss the topic of scalp melanoma. This event, which was broadcast live from Chapel Hill, was hosted by UNC Lineberger Comprehensive Cancer Center and UNC Cancer Network.
UNC Lineberger member Blossom Damania, PhD, the co-director of the UNC Lineberger Global Oncology Program and the UNC Lineberger Virology Program, has been named the new vice dean for research at the UNC School of Medicine. She will replace Terry Magnuson, PhD, who has been named the vice chancellor for research at UNC-Chapel Hill.
Chad Ellis, PhD, Ben Major, PhD, and Anne-Marie Meyer, PhD, traveled to the U.S. Capitol to meet with members of the North Carolina congressional delegation and explain the impact of National Institutes of Health and National Cancer Institute funding on the lives and well-being of people in North Carolina and the country.
UNC Hospitals' cancer program, whose flagship location is the N.C. Cancer Hospital, has earned national accreditation from the Commission on Cancer of the American College of Surgeons, with commendation in three areas: clinical research accrual, reporting of outcomes and oncology nursing care.
A study led by UNC Lineberger Comprehensive Cancer Center members Hanna Sanoff and Stacie Dusetzina found that the liver cancer drug sorafenib does not deliver on its promise of 11 months of longer life for some advanced liver patients, and can come with serious side effects and significant out-of-pocket costs.
For Eliza “Leeza” Park, MD, caring for people with cancer is not just about the disease - it’s about the person.
Published in the journal Science, a study by UNC School of Medicine researchers offers a new route to design the 'cellular machines' needed to understand and battle diseases.
The week of May 6-12 is National Nurses Week. At the UNC Lineberger Comprehensive Cancer Center and the N.C. Cancer Hospital, we've got some of the best. Read this Q&A with Ashley Farmer, BSN, RN, OCN, patient services manager in the Adult Oncology Infusion Center at UNC Hospitals.
In the lab of Channing Der, PhD, a UNC Lineberger member and a Kenan Distinguished Professor in the Department of Pharmacology, researchers believe they have found a promising strategy to target a type of pancreatic cancer that is notoriously resistant to treatment—pancreatic cancer that has a mutation in a gene called KRAS.
Shelton Earp, MD, director of UNC Cancer Care and a UNC Lineberger Comprehensive Cancer Center member, was named Inventor of the Year by the Chancellor’s Office of Innovation and Entrepreneurship at the University of North Carolina at Chapel Hill.
Targeting melanoma, lymphoma: Study finds investigational compound active against cancer driven by genetic mutation
Norman Sharpless, MD, and colleagues reported in Nature Medicine findings from a preclinical study that demonstrated that a potential new drug effectively targeted a genetic mutation linked to melanoma and the most common form of lymphoma.
Superior Court Judge Carl Fox hosted a “UNC Heroes” fundraising event for the Leukemia and Lymphoma Society on Sunday, April 24 in Carrboro, NC. Judge Fox was appointed as the first black District Attorney in North Carolina in 1984 and became Senior Superior Court Judge in 2005. He was diagnosed in 2015 with a type of blood cancer called myelodysplastic syndrome.
A study, authored by UNC Lineberger member Stacie Dusetzina, PhD, found that oral cancer drugs introduced in 2014 were, on average, six times more expensive than those introduced in the year 2000. The findings, published in JAMA Oncology, raised concerns as patients may increasingly take on the cost burden of those increases.
UNC Lineberger member Satish Gopal, MD, MPH, has called for a commitment to contribute resources and energy to control cancer in less-resourced countries where there are significant gaps in cancer awareness, prevention, diagnosis, and treatment.
More than 70 friends and loved ones of Dr. Minhthu Nguyen gathered at the N.C. Cancer Hospital on Friday, April 22 to celebrate her life and to participate in the dedication of the hospital’s Mammography Reception Area in her honor. Nguyen, a local dentist, passed away on September 8, 2015, following her courageous four-year battle against breast cancer.
At age 47, Debra Jackson was diagnosed with stage I adrenal cancer. Dr. Jen Jen Yeh was able to surgically remove all of Debra's cancerous tumor, but was worried about her patient's overall health and ability to recover. Now, three years later, Debra has lost 175 pounds, and is living healthy, happy and cancer-free.
UNC Lineberger member, UNC School of Medicine professor and basic scientist Keith Burridge has conducted seminal research on the basic building blocks of cells for four decades.
Sequencing a tumor's RNA in addition to its DNA makes it possible to better characterize the cancer’s mutations, reported Neil Hayes, MD, MPH, at the American Association for Cancer Research’s annual meeting. This additional information, said Hayes, may help improve a cancer patient’s treatment.
AACR 2016: Blood test could gauge treatment response for head and neck cancer patients, pilot study shows
A potential new blood test is sensitive enough to detect changes in numbers of head and neck cancer cells circulating in the blood, a pilot study by UNC Lineberger Comprehensive Cancer Center researchers and collaborators has found. The findings from the study will be presented at the American Association for Cancer Research Annual Meeting in New Orleans on Tuesday, April 19.
AACR 2016: UNC researchers identify promising strategy to stop an aggressive breast cancer type once it’s spread to the brain
UNC Lineberger Comprehensive Cancer Center researchers have identified a combination of investigational drugs that have been shown to be effective together at targeting triple negative breast cancer in the brain in preclinical studies. Their findings will be presented at the American Association for Cancer Research Annual Meeting in New Orleans, Tuesday, April 19.
A study by researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and other institutions found a link between higher intake of dietary saturated fat, a type of fat found commonly in foods such as fatty beef and cheese, and risk of aggressive prostate cancer. The preliminary results were presented at the American Association for Cancer Research Annual Meeting in New Orleans on Monday, April 18.
More than 440 people recently attended the 40th Annnual UNC Lineberger Scientific Symposium, which featured talks on treatments and ongoing research that target the RAS-RAF-MEK-ERK and other signaling pathways in cancer.
A study led by UNC Lineberger researchers has found that for women who have had a false-positive mammogram result, their likelihood to get screened at recommended intervals depends on the timing of their last screen. Louise Henderson, PhD, will present the findings at the American Association for Cancer Research Annual Meeting in New Orleans, Monday, April 18.
Jenny Ting, Ph.D. and her colleagues report research findings in Cell Host & Microbe that further explain the role of host proteins in viral replication and the innate immune response to HIV infection.
Katherine Reeder-Hayes, MD, MBA, and her colleagues report that women age 66 and older who have HER2-positive breast cancer were less likely than younger women to be treated with trastuzumab (Herceptin), a proven, yet expensive, drug therapy.
Recent work from the laboratory of Liza Makowski, PhD, UNC Lineberger member and assistant professor of nutrition at the UNC Gillings School of Global Public Health, explores two possibilities for breaking the link between obesity and basal-like breast cancer.
Bill Schaller has been appointed director of communications and marketing at UNC Lineberger Comprehensive Cancer Center, effective Feb. 22, 2016.
UNC Lineberger has welcomed two new members to its administrative staff, Dominique Waters and Bill Schaller, and has expanded the responsibilities of two others, David Darr and Wendy Sarratt.
UNC Lineberger's annual scientific symposium, “Molecularly Targeted Cancer Therapies from Bench to Bedside,” will be held April 11-12 at The William and Ida Friday Center for Continuing Education. Thanks to event supporters, attendance is free and the cost to for lunch is minimal at $16 per day. Registration is open until 5 p.m. on Wednesday, April 6.
Two UNC Lineberger Comprehensive Cancer Center members - Drs. Deborah Mayer and Barbara Rimer - have been honored with appointments to the National Cancer Moonshot Initiative's Blue Ribbon Panel. They will join a team of cancer experts to provide advice and vision in the implementation of the national program.
Weight loss surgery was more effective than a low-fat diet at reversing the cancer-promoting effects of chronic obesity in mice, UNC Lineberger Comprehensive Cancer Center researchers report in a new study. The preliminary findings will be presented April 18 at the 2016 American Association of Cancer Research Annual Meeting in New Orleans.
Researchers with UNC Lineberger examined whether weight loss via four different diets was linked to reduced tumor growth in laboratory models of breast cancer. While tumor size did not differ between obese mice and obese mice that returned to a normal weight on a low-fat diet, they did find that obese mice that lost significant amounts of weight on three calorie-restricted diets had smaller tumors.
A UNC Lineberger-led study has identified genetic differences in tumors of African-Americans with the most common type of kidney cancer compared with whites. The researchers, led by senior author Dr. William "Billy" Kim, say the findings could help explain lower survival rates for African-Americans with clear cell renal cell carcinoma.
Researchers at UNC Lineberger and at other institutions developed a new potential treatment for acute myeloid leukemia. In the journal JCI Insight, they report that the compound MRX-2843 more than doubled the median days of survival in laboratory models with a drug-resistant form of the disease.
In the journal Cell Reports, UNC Lineberger researchers reported they found markedly low levels of the protein NLRX1 in multiple laboratory models of colorectal cancer, and in samples of human tissue. Studies have shown that the protein is known to be involved in regulating immune system signals in order to prevent hyperactive inflammatory responses by the immune system, but UNC Lineberger researchers believe their finding also points to a role for the protein in preventing colorectal cancer growth. Based on their findings, they believe they’ve identified a potential treatment for colorectal cancer with low NLRX1.
Kirsten Bryant, PhD, a cancer researcher and postdoctoral fellow at the UNC Lineberger Comprehensive Cancer Center, and Channing Der, PhD, a UNC Lineberger member and the Sarah Graham Kenan Professor of Pharmacology, shared personal stories of why they're driven to fight pancreatic cancer at a breakfast in Durham on Tuesday.
In a first-of-its-kind-study, researchers have discovered and applied a new screening technique capable of testing thousands of potential drug compounds to see if those compounds can reverse abnormal DNA unwinding in Ewing sarcoma, a bone and soft tissue cancer that’s most common in teens and young adults.
A preclinical study led by a UNC Lineberger Comprehensive Cancer Center researcher found that skin cells turned cancer-killing stem cells hunt down and destroy the deadly remnants inevitably left behind when a brain tumor is surgically removed.
Albert S. Baldwin, UNC Lineberger’s associate director of basic research and the William Rand Kenan Professor of Biology at UNC, will receive nearly $5.9 million across seven years as a recipient of the National Cancer Institute's Outstanding Investigator Award. He is the second UNC Lineberger researcher to receive the award behind Stephen Hursting, who is studying the link between obesity and cancer.
Eric Strand, currently a student at the UNC School of Medicine, has quite a story to tell. The Green Beret medic -turned aspiring oncologist talked about second chances with attendees of the Lineberger Club Brunch and Basketball Game on Saturday, Feb. 20.
Online e-cigarette searches number in the millions, but few focus on vaping health risk or quitting smoking
A study published recently in the American Journal of Preventive Medicine found that Google searches about electronic cigarettes were more commonly related to shopping for e-cigarettes, while quitting smoking represented less than 1 percent of e-cigarette searches in each of 2013 and in 2014. The study’s senior author was Rebecca S. Williams, MHS, PhD, a UNC Lineberger member.
Study finds different genetic mutation patterns for HPV-positive throat cancer patients based on smoking history
Researchers at UNC Lineberger Comprehensive Cancer Center have presented preliminary findings from a study examining the genetic alterations in HPV-positive oropharyngeal squamous cell carcinoma, a cancer of the head and neck. The researchers found differences in the genetic mutations of HPV-positive oropharyngeal cancer based on whether patients were heavy versus light smokers.
UNC Lineberger researcher Dr. Ronald C. Chen was first-author of a report published in the Journal of Clinical Oncology that details guidelines for the active surveillance of men with low-risk prostate cancer. The guidelines, originally authored by Cancer Care Ontario, were reviewed and endorsed by the American Society of Clinical Oncology.
As part of the “Cancer Moonshot” federal initiative to spur breakthroughs in cancer research, Biden hosted a roundtable discussion on Wednesday at the Duke University School of Medicine that featured cancer experts and leaders from UNC. Among the experts chosen for the panel were Stephanie Wheeler, PhD, UNC Lineberger member and assistant professor of health policy and management at the UNC Gillings School of Global Public Health and Niklaus Steiner, UNC-Chapel Hill professor and co-founder of the Chapel Hill-based Be Loud! Sophie Foundation, which supports adolescents and young adults with cancer.
At the 10th Annual UNC Conference on Melanoma and Complex Skin Cancers: A Multidisciplinary Perspective, experts in melanoma treatment presented advances in treating the disease on Thursday. The conference, held at the William and Ida Friday Center for Continuing Education, drew dermatologists, surgeons, medical oncologists and other health care providers to hear presentations on topics ranging from immunotherapy drugs and targeted treatments for metastatic disease, radiation strategies, and chemotherapy to prevent skin cancer.
A new implantable device delivers first-line treatment for pancreatic cancer directly to tumors, bypassing bloodstream and limiting widespread side effects. A team of researchers from the University of North Carolina including Drs. Jen Jen Yeh and Joseph DeSimone, has shown in preclinical research that the device can deliver a particularly toxic dose of drugs directly to pancreatic tumors to stunt their growth or, in some cases, shrink them. This approach would also spare the patient toxic side effects.
Zika, the virus currently causing worldwide concern due to its alarming connection to a neurological birth disorder, was discussed as part of a presentation on emerging infectious diseases for the UNC Lineberger-led seminar series titled "Virology in Progress." Helen Lazear, PhD, a UNC Lineberger member and an assistant professor in the UNC School of Medicine Department of Microbiology and Immunology, spoke about Zika and noted that experts know relatively little about the virus.
A new report from the American College of Physicians’ High Value Care Task Force issues advice for physicians on how to detect and evaluate blood found in the urine, which is known as hematuria. The report, which was first-authored by UNC Lineberger Comprehensive Cancer Center member Dr. Matthew Nielsen, also raises questions about the potential harms associated with diagnostic tests that are commonly employed to evaluate this condition.
UNC Lineberger joins nation’s cancer centers in endorsement of HPV vaccination for cancer prevention
UNC Lineberger Comprehensive Cancer Center has joined 68 of the nation's top cancer centers in urging increased vaccination for the human papillomavirus, or HPV. Recognizing insufficient vaccination rates present a public health threat, this nationwide network of experts is calling upon physicians, parents and young adults to take advantage of this rare opportunity to prevent many types of cancer.
Based on a survey of widowed fathers who had lost a spouse to cancer, UNC Lineberger researchers reported in the journal BMJ Palliative Care that additional research and improved end-of-life care are needed to specifically help dying parents as well as their families.
A preclinical study led by a UNC Lineberger researcher found that a nanoparticle form of a drug used to prevent bone loss was effective against small-cell lung and prostate cancer cells. The results were published in the journal Biomaterials.
UNC Lineberger was awarded a grant with the Medical University of South Carolina Hollings Cancer Center to support a collaborative effort to address disparities in cancer incidence and death across North and South Carolina and Tennessee. In addition, the cancer center has received a grant to support the work of a community health educator to enhance outreach and education, and to disseminate culturally-appropriate, evidence-based cancer information in North Carolina.
UNC Lineberger researchers found in a study published in PLOS ONE that the diabetes drug metformin failed to show any benefit against pancreatic cancer, despite excitement about the drug for potential anti-cancer benefits. They believe the study shows the importance of testing new therapies in preclinical animal models that incorporate actual tumor tissue to better predict patient response.
After years of providing spiritual guidance and counseling to UNC patients, many of whom had cancer, the tables turned on hospital chaplain Shay Greene. On Sept. 16, 2011, she was diagnosed with Stage 3 breast cancer. Following a mastectomy, radiation, chemo and breast reconstruction, Greene says she was changed forever. Here, she tells the story of how a pen and paper became the tools that helped her move forward in her own faith and renewed her ministry to others who are going through cancer.
In the journal Cancer Cell, UNC Lineberger researchers report findings of a promising strategy to treat KRAS-mutant pancreatic cancers. Preclinical studies showed promise for using a type of investigational drug that works by inhibiting the protein ERK, the last of a series of signals of a signaling pathway that drives drive abnormal growth of cells with KRAS mutations.
Researchers at UNC Lineberger Comprehensive Cancer Center found that breast cancer patients surveyed about their knowledge of breast reconstruction were only moderately informed about the procedure, and their knowledge of complications was low. The study, published in the journal Annals of Surgery, surveyed 126 breast cancer patients planning to undergo mastectomy at the N.C. Cancer Hospital.
Joseph DeSimone is the Chancellor’s Eminent Professor of Chemistry in the College of Arts and Sciences at the University of North Carolina at Chapel Hill and a member of UNC Lineberger. He will be honored in a ceremony at the White House.
In the journal Cell Reports, UNC Lineberger researchers report that when they removed Dicer from preclinical models of medulloblastoma, a common type of brain cancer in children, they found high levels of DNA damage in the cancer cells. The tumor cells were smaller, and also more sensitive to chemotherapy.
UNC-Chapel Hill researchers show how social relationships reduce health risk in each stage of life in a new study. UNC Lineberger member Yang Claire Yang said the analysis "makes it clear that doctors, clinicians, and other health workers should redouble their efforts to help the public understand how important strong social bonds are throughout the course of all of our lives.”
UNC Lineberger researchers reveal clues to breast cancer metastasis at San Antonio Breast Cancer Symposium
Researchers and physicians from around the globe convened Dec. 8-12 for the 2015 San Antonio Breast Cancer Symposium at the Henry B. Gonzalez Convention Center in San Antonio, Texas. UNC Lineberger researchers presented preliminary findings from studies focused on genomic clues to breast cancer metastasis, the link between obesity and cancer, and on the use of genetic sequencing to find targeted treatments for individual patients.
UNC Lineberger researchers presented clinical, preclinical and population-based research at the ASH Annual Meeting Dec. 5-7. They presented findings from a study evaluating a treatment for a type of chemotherapy-resistant lymphoma and from an investigation into that the rate of fertility counseling for young men with cancer.
UNC Lineberger member and gynecologic oncologist Dr. Groesbeck Parham has worked in Zambia for the past 11 years and in Africa since 1985. Last year, he received a grant from the National Cancer Institute (NCI) grant to build a cancer-related research platform between UNC sites in Zambia and Malawi. Now Parham has extended the reach of his program to Malawi, helping to train a physician there in radical hysterectomy to treat cervical cancer.
Oral chemotherapy drugs are so expensive that they will be out of the financial reach of most Medicare patients even when the Part D doughnut hole closes in 2020, according to new study from the University of North Carolina at Chapel Hill.
An Internet-based system for symptom collection benefited patients while giving them a clearer voice in their own care.
UNC Lineberger hosted its second speed-date at the Pagano Conference Room to match biomedical engineers from the UNC & NC State Joint Department of Biomedical Engineering with surgeons from the UNC School of Medicine Department of Surgery. Competitors formed teams to pitch research ideas, with the top three teams winning grant awards.
Ron Chen, MD, MPH, a physician-researcher at the University of North Carolina Lineberger Comprehensive Cancer Center and an associate professor in the UNC School of Medicine Department of Radiation Oncology, made a decision as a college student that ultimately led him to his calling as a cancer physician and researcher.
The new cancer drug delivery system developed by the UNC School of Medicine and North Carolina State University improves efficacy of standard chemotherapy for ovarian cancer in mice with limited toxicity.
A survey of young women who use tanning beds found that despite being aware of the health risks associated with indoor tanning, they continue to take part in the activity, according to research conducted by University of North Carolina Lineberger Comprehensive Cancer Center.
Women with a history of a false-positive mammogram result may be at increased risk of developing breast cancer for up to 10 years after the false-positive result, according to a study led by a UNC Lineberger researcher. The study was published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Stephen Hursting, PhD, a UNC Lineberger member and professor of nutrition at the UNC Gillings School of Global Public Health and the UNC Nutrition Research Institute, has received a prestigious National Cancer Institute Outstanding Investigator Award. Hursting is one of 43 researchers nationwide to receive the award, which will provide $5.34 million over a seven-year period to further research on the mechanistic links between obesity and cancer.
Aziz Sancar, MD, PhD, was awarded the 2015 Nobel Prize in Chemistry. A Chapel Hill resident since 1982, Dr. Sancar has been honored with a key to the city of Chapel Hill by Mayor Mark Kleinschmidt and the town council.
Elizabeth Stewart started "Hats for Hope," the Annual Charli’ Ramsey Hat Drive to honor the memory of her daughter, Charli’ Ramsey. She collects donated new and handmade hats, scarves, blankets and other items to deliver to patients at the N.C. Cancer Hospital.
UNC Lineberger member Ben Major, PhD discussed his American Cancer Society grant work on genetic mutation that occurs in 30 percent of all lung cancers, explaining how his research could result in new treatment therapies.
UNC Lineberger researchers say the findings of a new study published in the journal Quality of Life Research indicate that activity trackers could be a useful tool for tracking symptoms and physical function. These trackers may be especially useful for patients who are not able to self-report symptoms using questionnaires because of language barriers, literacy, cognitive or health status.
UNC Lineberger researchers are studying a new form of ultrasound that can image the abnormal blood vessels feeding tumors. In a new study, they used this ultrasound technique to show that the abnormal blood vessels feeding cancer tumors extend beyond the tumor borders.
Researchers surveyed more than 700 pediatricians and family physicians about their recommendations for the HPV vaccine, finding that 27 percent did not strongly endorse the vaccine. The findings are significant as low uptake of HPV vaccination is contributing to a national crisis in cancer prevention, said UNC Lineberger researcher and study senior author Noel Brewer.
North Carolina’s health care providers from across the state met in Chapel Hill on Friday, Oct. 30 for the 7th Annual Coping with Cancer Symposium hosted by UNC Lineberger Comprehensive Cancer Center, UNC Cancer Network and the Comprehensive Cancer Support Program.
A UNC Lineberger-led study published in the Journal of Clinical Oncology identified a group of women with HER2 positive breast cancer who could benefit from less intensive targeted treatment
UNC Lineberger and North Carolina Central University were awarded grants totaling more than $11 million for cancer research that addresses disparities in cancer incidence and death for African-Americans in North Carolina.
The award, made possible through a donation from Lenovo chairman and CEO Yuanqing Yang, recognizes the research achievements of young tenured faculty.
In the recent U.S. News and World Report rankings of America’s Best Hospitals, UNC Hospitals was nationally ranked in five of the 16 specialties. In this series by UNC School of Medicine, a closer look is taken at these specialties to learn more about what makes them so outstanding.
Most HPV-positive head and neck cancer patients cancer-free with lower intensity chemo and radiation
A study led by a UNC Lineberger researcher found that lower doses of chemotherapy and radiation produced complete pathologic responses in 86 percent of a group of HPV-positive patients.
UNC Lineberger Comprehensive Cancer Center receives $10 million commitment to support cancer research
The University of North Carolina at Chapel Hill today announced a $10 million gift commitment to the UNC Lineberger Comprehensive Cancer Center from Ken and Cheryl Williams of Burlington, N.C. The couple has designated their gift for the Ken and Cheryl Williams Fund for Venture Initiatives at UNC Lineberger, the state’s only public comprehensive cancer center.
UNC Lineberger Comprehensive Cancer Center researchers are working to better understand the cell-to-cell signaling that can cause precancerous polyps in the colon when signaling goes awry. In a study published in the open-access journal eLife, they describe the role of a key tumor suppressor protein called APC in helping to keep cells in the colon crypts from growing out of control.
After Tom and Nancy Chewning's daughter, Wilson, was diagnosed with breast cancer, they began to research the best treatment options for her. Their search led them to UNC Lineberger and Dr. Lisa Carey. Now with Wilson cancer-free, the Chewnings are investing in the Dr. Lisa Carey Fund for Breast Cancer Innovations so that others may also benefit from the most cutting-edge breast cancer research and treatment.
UNC Lineberger-led study finds higher vitamin D and calcium intake does not reduce colorectal polyp risk
A UNC Lineberger-led study published in the New England Journal of Medicine found that vitamin D and calcium supplements do not reduce the risk of colorectal adenomas, which are benign tumors that can evolve into colorectal cancer.
UNC Lineberger co-hosted Ted Trimble, MD, MPH, director of the Center for Global Health at the National Cancer Institute, for the inaugural Global Oncology Lecture, held Oct. 1 at the UNC Gillings School of Global Public Health.
The 40th annual Postdoc-Faculty Research Day drew approximately 150 people to the William & Ida Friday Center for Continuing Education on Sept. 30 for spoken presentations and a poster session by UNC Lineberger postdoctoral fellows.
Tar Heel basketball Coach Roy Williams' 2015 "Fast Break Against Cancer" breakfast fundraiser featured Brigham Young University Men's Basketball Head Coach Dave Rose - also a pancreatic cancer survivor - as its keynote speaker. Now in it's 11th year, Fast Break Against Cancer has surpassed the $2 million mark for cancer research and treatment at UNC Lineberger Comprehensive Cancer Center.
UNC Lineberger Comprehensive Cancer Center researchers helped lead an effort by The Cancer Genome Atlas Network of researchers to map the genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer. They found that this cancer type may be at least three different diseases that differ in their microenvironmental features and outcomes.
Aziz Sancar, MD, PhD, a UNC Lineberger Comprehensive Cancer Center member and professor at the UNC-Chapel Hill School of Medicine, was a part of a team that mapped part of the DNA repair system that protects genes against cancer. Dr. Sancar shares the 2015 Nobel Prize in Chemistry with two other biochemists - Dr. Tomas Lindahl of the U.K. and Dr. Paul Modrich of Duke University.
A UNC Lineberger researcher and his team describe the design and engineering of the new bioluminescent imaging tool called the “LumiFluor” in a study published in the journal Cancer Research.
A science class captured Catherine Fahey’s imagination. A mother’s battle with cancer led her to pursue medicine as a career. At UNC, Fahey found a home at the junction of research and patient care.
The air was alive with the spirit of celebration on Friday, Sept. 18, when nearly 400 cancer center supporters gathered at the Carolina Club for the 2nd UNC Lineberger Comprehensive Cancer Center Blue Ribbon Gala.
A UNC Lineberger researcher is a co-investigator with Sunnyvale, Calif.,-based InSilixa Inc. for the development of a rapid oral HPV test.
UNC Lineberger Comprehensive Cancer Center researchers and eight other leading cancer research institutions have won a five-year, $12 million grant to try to find treatments for a group of cancers linked to mutations in the NF1 gene.
Researchers from Norway visited UNC Lineberger Comprehensive Cancer Center to learn firsthand about UNCseq, a clinical trial launched in 2011 at the N.C. Cancer Hospital. In the trial, researchers use a profile of the genetic and molecular alterations in patients' tumors to try to identify targeted treatments for them.
UNC Lineberger’s application for renewal of a major five-year, federal grant earned an "exceptional" rating from the National Cancer Institute. The rating is the highest that a cancer center can earn for the application.
UNC-Chapel Hill to break new ground in health innovation by mapping potential drug targets and freely sharing discoveries with no strings attached
A new hub of the Structural Genomics Consortium housed at UNC-Chapel Hill’s Eshelman School of Pharmacy will encourage a widespread and unrestricted use of its findings to accelerate discovery of breakthrough medicines for diseases ranging from cancer to rheumatoid arthritis to Alzheimer’s.
UNC Lineberger researchers are among a group of UNC School of Medicine faculty members headed to Washington to rally for research.
An $11.3 million, five-year grant from the National Cancer Institute will fund four studies by researchers with the Carolina Center of Cancer Nanotechnology Excellence.
A UNC Lineberger-led study, published today in Nature Genetics, paves the way for potential personalized medicine approaches for the deadly cancer type.
Norman E. Sharpless, MD, UNC Lineberger Comprehensive Cancer Center's director and the Wellcome Distinguished Professor in Cancer Research, delivered the State of the Cancer Center address at the 2015 UNC Lineberger Annual Scientific Retreat.
Cash prizes of $250, $150, and $100 were given for the best posters in each of the three categories presented at the 2015 UNC Lineberger Annual Scientific Retreat. Students and fellows who first-authored the studies presented were eligible for awards.
In Malawi’s capital city, one pathologist has played an important role in speeding cancer diagnoses and supporting cancer research.
In the population-based, case study published Monday in the Annals of Internal Medicine, researchers led by Danish scientists honed in on the patterns of use of aspirin and NSAIDs needed for protection from colorectal cancer.
Even in the midst of treatment, many cancer patients are finding that exercise helps them to feel better, both physically and emotionally. Through the Get Real & Heal program, UNC researchers are digging deeper into the science behind why moving more can make a positive impact on patients' overall health and well-being.
UNC Lineberger member Frances Collichio, MD, was an investigator for a clinical trial for a treatment that uses a modified virus against melanoma. The treatment meant remission for Willis Davis, who had been diagnosed with stage IIIc melanoma in 2009.
A study by UNC Lineberger Comprehensive Cancer Center researchers and collaborators found that women with gynecologic cancer who were enrolled in both Medicaid and Medicare had worse outcomes compared with women enrolled in Medicare alone.
A $2.4 million-grant from the National Institutes of Health will fund a collaborative research effort between UNC Lineberger Comprehensive Cancer Center and University of Nebraska Medical Center scientists. The researchers plan to study whether the use of a drug-carrying nanoparticle material they've designed can better penetrate tumors.
UNC Lineberger member James Bear, PhD, uncovers the intricate mechanisms that allow certain cells to move, discoveries with implications for cancer metastasis.
In an article published in JAMA Oncology today, a study led by UNC Lineberger's Ethan Basch and colleagues shows that a system they developed accurately and reliably captures the patient experience with cancer drug side effects.
Phineas was diagnosed with leukemia at age four and was not responding to the standard course of treatment. Thanks to the heroic efforts of UNC doctors, he was enrolled in a T-cell immunotherapy trial at NIH, which brought him into remission, and he is now cancer-free. UNC Lineberger is now bringing this same “wave of the future” treatment to the people of North Carolina.
As a breast cancer survivor, Barbara Martin has established a tradition – walking 39 miles to raise awareness and funds for breast cancer – that has become very special to her. This challenge became even more special this year, as her mother and daughter were both by her side along the way.
Each month, the technology company IBM releases a podcast called “Wild Ducks,” focusing on world-changing people and ideas. For the month of July, IBM came to UNC Lineberger Comprehensive Cancer Center to learn about personalized medicine and meet their newest Wild Duck – Ned Sharpless, MD, UNC Lineberger Director and Wellcome Distinguished Professor in Cancer Research at the UNC School of Medicine.
Newsweek, in conjunction with Castle Connolly Medical LTD, has published its list of the “Top Cancer Doctors in the United States for 2015.” UNC Lineberger is proud to announce that 22 of those physicians listed are affiliated with UNC Cancer Care.
Protecting the gastrointestinal system during chemotherapy or radiation could allow patients to tolerate more aggressive treatments to attack tumors.
Michele Hayward, a research director at UNC Lineberger, was honored on Monday by 97.9 WCHL Chapelboro.com with the Hometown Heroes Award.
UNC Hospitals is once again nationally ranked in cancer, taking the 32nd spot in the country in a U.S. News & World Report ranking of over 900 hospitals across the country. The latest ranking is up from 38th in 2014 and 43rd in 2013.
Lisa Carey, MD, medical director of the UNC Breast Center, division chief of hematology and oncology at the UNC School of Medicine, and physician-in-chief of the N.C. Cancer Hospital and Chuck Perou, PhD, the May Goldman Shaw Distinguished Professor of Molecular Oncology, have published an editorial in the July 16 issue of The New England Journal of Medicine entitled “Palbociclib — Taking Breast-Cancer Cells Out of Gear.”
In a study published today in the journal Proceedings of the National Academy of Sciences, UNC Lineberger researchers report findings of how Kaposi’s sarcoma-associated herpesvirus, or KSHV, can inhibit a signaling pathway involved in triggering part of the early immune response to the virus.
Twelve cancer researchers have won awards from the spring cycle of the UNC Lineberger Comprehensive Cancer Center’s Developmental Grants program for basic science, clinical/translational and population-based cancer research.
UNC Lineberger Comprehensive Cancer Center member Channing Der, PhD, is among four accomplished cancer researchers to join the Pancreatic Cancer Action Network’s prestigious board.
Amy Charney had already registered to run the 2015 Boston Marathon when she was told she had breast cancer. But not even that diagnosis and active treatment would keep her from crossing the finish line in her hometown of Boston.
Ten-year-old Ellie Stewart was diagnosed with choriocarcinoma in February. Her only plans for the summer were to finish her chemotherapy treatment at N.C. Children’s Hospital. Then she received a surprise gift: tickets to attend Taylor Swift’s June 9 concert in Raleigh. Now Ellie has some memories to help carry her through.
Kemi Doll, MD, Aaron Falchook, MD, and Benjamin Vincent, MD, were honored as the recipients of the 2015 Pope Clinical Fellows Awards.
Blossom Damania, PhD, studies how viral cancers develop, and also directs the UNC Lineberger Comprehensive Cancer Center Global Oncology Program.
The university has received a grant from the National Institutes of Health to create a postdoctoral training program in cancer nanotechnology within the UNC Eshelman School of Pharmacy.
UNC Lineberger lost a dear friend and colleague, Dr. Michael O’Malley, on June 24. A memorial service to honor Michael will be held on Saturday, Aug. 22, in the auditorium of the Genome Sciences Building (rm G200) on the UNC campus. The time of the event has yet to be determined and will be provided at a later date.
The UNC Lineberger Comprehensive Cancer Center co-sponsored a speed-dating and pitch competition on June 29 to try to spark medical technology innovation. The top five teams that emerged from five-minute speed-dating sessions with pitches for new medical technologies won funding to help advance their ideas.
Adam Belanger, MD, a second-year pulmonology fellow in pulmonary diseases and critical care medicine at the UNC School of Medicine, was one of four North Carolina researchers to win a research grant from the Lung Cancer Initiative of North Carolina’s Research Fellows Program.
Seven scouts travel cross country to raise dollars and awareness for adolescent and young adult cancer patients at UNC Lineberger through the Be Loud, Sophie! Foundation.
High school dropout, Green Beret medic who served three tours in Iraq, Special Forces medic instructor at Fort Bragg, lymphoma fighter who is free of cancer today, and future physician and researcher -- the remarkable path to medicine of rising third-year UNC medical student Eric Strand.
In a study published in Nature Medicine, UNC Lineberger Comprehensive Cancer Center researchers report their findings of just how a certain tumor-suppressing protein helps prevent colon cancer. With this discovery, the researchers believe they’ve found a possible drug target for colon cancer patients who lack the tumor suppressor.
A UNC Lineberger Comprehensive Cancer Center researcher led a panel of experts to develop recommendations for how to best develop patient-focused assessments of health care performance. They published their findings in an article in the journal Value in Health.
UNC Lineberger team finds possible strategy to overcome radiation therapy resistance acquired by cancer cells
In a new study published in the Cell Press journal Chemistry & Biology, researchers share a discovery that they say could lead to a new strategy for sensitizing radiation-resistant cancer cells to the treatment.
In a new pre-clinical study published today, UNC Lineberger researchers show that they can exploit cancer’s reliance on a particular protein to help fight triple negative breast cancer. They believe the protein could be a potential new drug target.
Veatrice Harris wasn’t afraid of battling cancer. She leaned on her faith, her family, and her UNC caregivers to face the toughest year of her life. Now, thanks to an innovative procedure called a 50/50 bone marrow transplant, Veatrice has renewed hope for 2015.
UNC Lineberger researchers significantly contributed to a better understanding of the genetic alterations found in cutaneous melanoma as part of a multi-institution, international effort of The Cancer Genome Atlas (TCGA). Researchers collected samples from 331 patients and used several molecular methodologies to complete the study, the largest of its kind to-date for cutaneous melanoma. The findings were published in the journal Cell.
Early menarche may be important in development of aggressive breast cancer in African-American women
A multicenter research team known as the African American Breast Cancer Epidemiology and Risk Consortium (AMBER), which includes UNC Lineberger's Andrew Olshan, PhD has uncovered differences in ER-positive & ER-negative breast cancer pathways. The team examined whether relationships between age at menarche and breast cancer are the same for tumors that are ER-positive or ER-negative, particularly among African-American women. ER-negative breast cancer is generally more aggressive and known to be associated with a poorer prognosis than ER-positive disease.
UNC Lineberger will be enrolling patients into a new, national clinical trial, known as NCI-MATCH, that will group patients based on the genetics of their tumors as opposed to where their cancer is located. The new initiative will test more than 20 drugs or drug combinations targeting specific genetic mutations.
Jenny Ting, PhD, a UNC Lineberger Comprehensive Cancer Center member and a William R. Kenan Jr. Distinguished Professor in the UNC School of Medicine Department of Genetics, has studied genetic and molecular mechanisms behind immune system development for more than three decades at UNC. Now she’s helping to lead two major federal center grants to further vaccine development and boost our understanding of immune responses to viruses.
The assessment, co-published by UNC Lineberger member and professor of gynecologic oncology Groesbeck Parham, MD, not only identifies the roadblocks to treatment, but also provides a path to overcoming them.
Katherine Reeder-Hayes, MD, MBA, Msc, a UNC Lineberger member and a clinical assistant professor in the University of North Carolina School of Medicine, won a Career Development Award from the Conquer Cancer Foundation of the American Society of Clinical Oncology. She was one of 11 clinical investigators chosen to receive the three-year award, which goes to researcher-physicians to help them build independent clinical research programs.
Nearly a year ago, thirteen-year-old Liam Canard, of Raleigh, was diagnosed with Hodgkin’s lymphoma. Although his fight against the disease goes on today, he has already won by continuing to do what he loves.
UNC Lineberger members were authors on nearly 30 abstracts that will be presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago being held May 29-June 2, 2015.
UNC Lineberger researcher Ben Major, PhD, an assistant professor in the UNC School of Medicine Department of Cell Biology and Physiology, studies cell signaling pathways in normal and cancerous cells. He hopes that a finding made by his team earlier this year could lead to a new treatment for a typically fast-growing type of lymphoma.
UNC Lineberger member Michael R. Kosorok, PhD, W.R. Kenan Jr. Distinguished Professor and chair of biostatistics at UNC’s Gillings School of Global Public Health, is the contact principal investigator for an multi-institution effort to continue to find ways to develop more powerful clinical trials for cancer patients. The project is backed by a five-year, $10.4 million grant from the National Cancer Institute.
UNC Lineberger researchers are collaborating through the ClinGen consortium - a program launched to evaluate the clinical relevance of genetic variants - to help physicians make predictions about an individual’s risk of disease, develop more accurate clinical trials and design individualized treatments and care for patients.
The latest installment in the Family House Diaries video series features Dr. Tom Shea, the Director and Founder of UNC's Bone Marrow Transplant Program, and Joe and Veatrice Harris of Roanoke Rapids, North Carolina.
Adam Belanger, MD, a second-year fellow at UNC School of Medicine, has received the Conquer Cancer Foundation of ASCO's Young Investigator Award. The award provides research funding to promising physicians to support the transition from fellowship to faculty appointment, encourage continued interest in clinical cancer research and assist them in their careers as both physicians and researchers. Recipients will each receive a one-year grant of $50,000 to fund their studies as they begin careers in oncology research.
Emily Guerard, MD, a fellow in the UNC School of Medicine Division of Hematology/Oncology, and Stephanie Wheeler, PhD, MPH, a UNC Lineberger member and an assistant professor of health policy and management in the UNC Gillings School of Global Public Health, have been honored with 2015 Conquer Cancer Foundation of ASCO Merit Awards.
A four-year grant from the National Cancer Institute will fund a pre-clinical study of molecular ultrasound imaging technology that researchers believe can better gauge whether cancer treatments are working.
$125,000 donation by company to fund UNC Lineberger Comprehensive Cancer Center Pediatric Oncology Retreat
The 2015 Susan G. Komen Triangle Race for the Cure is scheduled for Saturday, June 13th on the campus of Meredith College in Raleigh, NC.
In his new role as senior executive director of development and communications at UNC Lineberger, Martin Baucom will lead the organization’s efforts to secure philanthropic support and expand awareness of the center to further the work of scientists and physicians who are revolutionizing cancer research and lifesaving care for the people of North Carolina.
Faculty in the UNC School of Medicine Department of Radiation Oncology have co-authored a new book that details initiatives launched at UNC to maximize radiation therapy safety.
These days Bobby Kadis is living life to the fullest. After being diagnosed with Stage 4 lung cancer, he enrolled in a UNC Lineberger clinical trial using a combination of targeted drug therapies. Now the avid potter, mountain climber and yoga enthusiast celebrates being cancer-free.
On Saturday, May 9, the General Alumni Association at the University of North Carolina at Chapel Hill honored Dr. H. Shelton “Shelley” Earp III, director of UNC Cancer Care and former director of the UNC Lineberger Comprehensive Cancer Center, for his outstanding service to the University and to the association.
A University of North Carolina at Chapel Hill analysis published today in the journal Tobacco Control synthesized the results of 37 different experiments comparing picture-based and text warnings, finding that picture-based warnings were more effective than text warnings on 20 of 25 different outcome measures.
UNC Lineberger will be one of more than a dozen leading cancer centers tapping IBM's Watson to accelerate DNA analysis and inform personalized treatment options for patients. The project is part of IBM’s broader Watson Health initiative to advance patient-centered care and improve health.
A busy mom of two, Ellen Martin battled breast cancer with two powerful weapons – resilience and research. Following an aggressive breast cancer diagnosis, Ellen is now in remission thanks to a treatment plan driven by the latest findings in breast cancer research.
UNC Lineberger members awarded 2015 UNC Health Care and Faculty Physicians Award for Carolina Care Excellence
UNC Health Care administers the CMS-approved Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CG-CAHPS) survey to solicit feedback from our patients. Many UNC Lineberger physicians received the highest-possible honors from the patients they serve.
The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
A new treatment for melanoma could be on the horizon, thanks to a finding by a UNC Lineberger Comprehensive Cancer Center-led team. In the study, which was published online today in the journal Clinical Cancer Research, the authors report that they found high levels of an enzyme in melanoma samples that they believe is a potential drug target.
Using a new ‘chemogenetic’ technique invented at UNC, scientists turn neurons ‘on’ and ‘off’ to demonstrate how brain circuits control behavior in mice. This unique tool – the first to result from the NIH BRAIN Initiative – will help scientists understand how to modulate neurons to more effectively treat diseases.
Siler City native Roger Johnson knows the value of personalized medicine. After being diagnosed with bladder cancer in 2013, physicians at UNC sequenced his tumor to better understand the genetics driving his cancer.
New treatment strategies have given more triple-negative breast cancer patients the choice of breast-conserving surgery. But research led by Brigham and Women's Hospital, in collaboration with UNC Lineberger member David Ollila, MD, has shown that even when given the choice, more than 30 percent of patients still chose to have a complete breast removal via mastectomy.
The Pancreatic Cancer Action Network and the American Association for Cancer Research announced April 16 that UNC Lineberger's Channing Der, PhD, and two co-principal investigators were chosen to receive a $1 million grant for pancreatic cancer research. Earlier this year, Der was also announced as the recipient of a grant from The Lustgarten Foundation, the nation’s largest private funder of pancreatic cancer research.
UNC Lineberger's Jen Jen Yeh, MD, has been elected to the American Society for Clinical Investigation, an honor society for physician-researchers. A formal induction ceremony was held April 24 at the joint ASCI/AAP meeting in Chicago.
A cancer genomics study led by UNC Lineberger researchers and other scientists involved in The Cancer Genome Atlas (TCGA) project, a National Cancer Institute and National Human Genome Research Institute-backed effort to create a comprehensive atlas of the genetic changes in cancer, was selected as one of the top 10 clinical research achievements of the year. The project characterized molecular changes in 12 different cancers and revealed a new approach to classifying cancers.
Fifteen years ago, Nancy Raasch was diagnosed with metastatic breast cancer. Then, in 2009, came multiple myeloma. Despite these malignancies, she refuses to let cancer define her.
UNC Lineberger-led report details strategies for including patient-reported outcomes in cancer drug labeling
A UNC Lineberger-led report published online in JAMA Oncology describes barriers to getting patient-reported outcomes information into cancer trials and drug labels in the United States as well as recommendations for overcoming those obstacles.
Stupid Cancer, a nonprofit organization focused on young adult cancer awareness, visited the N.C. Cancer Hospital on April 11 as part of its nationwide advocacy tour. The Stupid Cancer Road Trip is a grassroots campaign aiming to increase awareness of young adult cancer throughout the country. While stopping in major U.S. cities, Kenny Kane and John Sabia tour cancer centers, host special events and get to know the local cancer communities.
On Saturday, April 11, UNC Women’s Basketball Coach Sylvia R. Hatchell hosted a UNC Lineberger Comprehensive Cancer Center Blueberry Patch “work day” at her land in the North Carolina mountains, located between Black Mountain and Fairview.
UNC Lineberger Comprehensive Cancer Center researchers will share their study findings and expertise at the American Association for Cancer Research’s annual meeting, which is expected to draw thousands to Philadelphia April 18-22 to discuss advances in cancer science.
UNC Lineberger's 39th annual scientific symposium was held April 8-9 at the William and Ida Friday Center for Continuing Education in Chapel Hill.
Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.
A UNC Lineberger-led study found that people with higher-risk melanoma containing either BRAF or NRAS gene mutations had lower survival rates.
Medicare recipients, private insurance patients and the uninsured all pay different prices for the same cancer treatments
UNC sequenced the RNA for 10,000 tumor samples as part of The Cancer Genome Atlas project, a National Cancer Institute and National Human Genome Research Institute-backed effort to create a comprehensive atlas of the genetic changes in cancer.
To lead into segments of PBS’ three-part series “Cancer: The Emperor of All Maladies,” UNC-TV planned broadcasts featuring health care providers from UNC.
Results from a UNC Lineberger-led study were published Monday in the journal Molecular Cancer Therapeutics. The pre-clinical study was the first to investigate one particular drug strategy as a treatment for breast cancer after it's spread to the brain.
The UNC Lineberger Comprehensive Cancer Center’s Director of Cancer Survivorship Deborah K. Mayer, PhD, RN, has been recognized for her commitment to the Oncology Nursing Society and to the community as a whole.
Two new faculty members have joined the UNC Lineberger Comprehensive Cancer Center to help launch groundbreaking immunotherapy clinical trials that will test an experimental treatment in which patients’ own immune cells are genetically engineered to fight their cancer.
A symposium co-sponsored by the UNC Lineberger Comprehensive Cancer Center brought leading breast cancer researchers together Friday to share findings about the genetic and environmental factors driving disparities in the disease’s incidence and mortality.
The use of robot-assisted surgery and modern radiation techniques have been rapidly adopted as treatments for prostate cancer, but a UNC Lineberger Comprehensive Cancer Center researcher is asking what the newer technologies will mean in terms of side effects and outcomes for patients in the long-term.
Charles M. Perou, PhD, professor of genetics and pathology at the University of North Carolina School of Medicine and the basic science leader of the UNC Lineberger Comprehensive Cancer Center Breast Cancer Research Program, has been acknowledged as a health care innovator by the Triangle Business Journal. During an awards ceremony on Thursday, Perou was selected from a pool of candidates as the finalist in the 2015 TBJ Health Care Heroes – Innovator category.
UNC Lineberger member Melissa Troester, PhD, values a team approach in her work and her personal life. As co-leader of the cancer center’s Cancer Epidemiology Program, Troester’s work is an important part of UNC Lineberger’s interdisciplinary research on the causes of breast cancer and the translational research on strategies of prevention, treatment and cure.
While studies have shown that the colonoscopy can reduce the risk of death from colorectal cancer, researchers have also shown that not all people recommended for the test actually get it. To help inform people about colorectal cancer risks and symptoms as well as the benefits of screening, the N.C. Cancer Hospital hosted a public outreach event last Thursday and Friday.
The American Cancer Society has honored Hyman B. Muss, MD, director of the UNC Lineberger Comprehensive Cancer Center Geriatric Oncology Program, with a prestigious national award that recognizes providers who show compassion and dedication beyond the call of duty.
A study led by a UNC Lineberger Comprehensive Cancer Center researcher has found that, despite a North Carolina law banning their purchase by minors and requiring online vendors to verify customer age, teens can easily buy electronic cigarettes online.
A dramatic increase in the thyroid cancer rate across the last 30 years has researchers asking whether the disease’s incidence is truly on the rise, or if improved detection methods are behind the trend.
Seeking the patient voice early in the cessation process is critical to success.
Hepatitis C virus infection is a common cause of liver disease and of liver cancer in the United States. Through a new study that explores one aspect of how the virus hijacks host cell machinery to replicate itself, UNC Lineberger Comprehensive Cancer Center researchers have gained insight into the workings of a potential drug target for hepatitis C.
The UNC Lineberger Comprehensive Cancer Support Program (CCSP) is now recruiting patients for a new online survey-based research study on the experiences of parents living with advanced cancer.
The ninth annual UNC Multidisciplinary Melanoma Conference brought more than 120 health care professionals from across the state on Thursday, February 12 to learn about the detection and treatment of melanoma.
The latest installment in UNC Health Care's Real Medicine video series features Ashley Burnette, 11-year-old cancer survivor and Patient Ambassador at the North Carolina Children's Hospital.
With new funding, a UNC startup is poised to halt the most devastating effects of chemotherapy.
To give back to an institution that he credits with saving his mother’s life, America’s top-ranked men’s singles tennis player John Isner returned to his hometown of Greensboro on Saturday, February 7th for his annual tennis exhibition event.