Katy Jones has been hired as director of communications and marketing for the UNC Lineberger Comprehensive Cancer Center, effective August 19, 2013.
William Roper, MD, MPH, Dean of the School of Medicine, Vice Chancellor for Medical Affairs, and CEO of University of North Carolina Health Care System, announces the appointment of Norman "Ned" Sharpless, MD, as director of the University of North Carolina Lineberger Comprehensive Cancer Center, effective January 1, 2014.
UNC Lineberger scientists Blossom Damania, PhD, Dirk Dittmer, PhD, and Liza Makowski, PhD, have been awarded two-year National Cancer Institute Provocative Questions grants.
"Scientists say blueberries powerful antioxidants and anthocyanins make them one of nature's top cancer fighters, two things that hit home for North Carolina women's basketball coach Sylvia Hatchell."
A team of researchers has published their analysis of survival rates among study participants in the 2003 Prostate Cancer Prevention Trial showing that the prostate drug finasteride does not decrease survival after a diagnosis of prostate cancer. Their 2003 publication found that while the drug finasteride significantly reduced the risk of prostate cancer, it was associated with an increased risk of high-grade disease and possibly decreased survival.
Like a toddler in need of a nap or a snack, the cells of our bodies can turn a bit sour under conditions of stress or nutrient deprivation. The pH levels inside these cells – starved, perhaps by a heart attack or other injury – have been known to drop dramatically in a cry for help.
Researchers at the University of North Carolina and the National Institutes for Health have defined the role of the protein vinculin in enabling cell movement. In a paper published in the Journal of Cell Biology, Sharon Campbell, PhD, professor of Biochemistry and Biophysics and member of UNC Lineberger Comprehensive Cancer Center, and Clare Waterman of the National Heart, Lung and Blood Institute at the National Institutes of Health showed that cell mobility occurs through the interactions between the protein vinculin and the cytoskeletal lattice formed by the protein actin. By physically binding to the actin that makes up the cytoskeleton, vinculin operates as a form of molecular clutch transferring force and controlling cell motion.
A rapidly-dissolvable microneedle patch developed by a UNC team led by Joseph DeSimone, William R. Kenan, Jr. Distinguished Professor of Chemistry and Chemical Engineering, and director of the UNC Institute for Advanced Materials, Nanoscience, and Technology and member of UNC Lineberger, allows for painless injections of medicine and vaccines.
Bob Goldstein, PhD, professor of biology, talks about his career and the promise of cell biology in a profile in the August issue of The Journal of Cell Biology.
Human bodies recognize at the molecular level that not all happiness is created equal, responding in ways that can help or hinder physical health, according to new research led by Barbara L. Fredrickson, Kenan Distinguished Professor of psychology in the College of Arts and Sciences at the University of North Carolina at Chapel Hill.
Since 2011, the University of North Carolina has partnered with the government of Malawi to establish a pathology laboratory in the nation’s capital, building on an existing decades-long collaboration. The laboratory has provided an invaluable service to patients and has also built capacity at a national teaching hospital, according to an analysis of the first 20 months of operation published August 7 online by PLOS ONE.
UNC Gazette - Oliver Smithies and Nobuyo Maeda were born in island countries half a world apart – he in England, she in Japan – but each in their own way found a path to a life in science.
Susan G. Komen for the Cure has awarded more than $800,000 to researchers with the UNC Lineberger Comprehensive Cancer Center to fund research into fighting cancer.
The tyrosine kinase MerTK plays a prominent role in the body’s immune response. MerTK signaling helps “calm” the body’s first line of immunity, the macrophage, while it performs the routine duties - clearing cells that die and healing damaged tissue.
Brian Burnham is an assistant scout master and one of the leaders of Troop 845's Lucky 13 Bike Trip, a fundraiser for UNC Lineberger.
Research that developed a method of visualizing aging and tumor growth in mice by Norman Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Deputy Cancer Center Director, was featured in an article on biological markers of aging in the New York Times.
UCRF Competitive Grants Program 2013 Innovation Awards were chosen from 51 applications. The awards provided $1,180,000 to support research among the six winners.
WRAL features Bill McCulloch, known as Windy City Slim, a blues singer who learned to reclaim his voice after treatment from head and neck cancer caused his vocal muscles to atrophy.
The National Institute of Health has awarded University of North Carolina researcher Lishan Su, PhD, with a $2 million four-year R01 grant to investigate using a novel immune therapy to treat chronic hepatitis B virus (HBV) infection.
Jahan Mohiuddin developed a tool to determine a patient’s risk of breast cancer relapse.
Albert Baldwin, PhD, Professor of Biology and Associate Director of Basic Research at UNC Lineberger discusses the regulation and biological functions of NF-κB in cancer at OncLive.
A 65-year-old Person County man is successfully treated for a rare head and neck cancer, but the treatment side effects damaged his teeth and gums. He may have lost his pearly whites, but not his spirit or his faith.
Shellie Ellis, MA, and Shelley Golden, PhD, of the Gillings School of Global Public Health are the 2013 recipients of the Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences.
RNA Diagnostic Test from Paraffin Improves Lung Cancer Diagnosis Over Routine Microscopic Evaluation Alone
Knowing what type of lung cancer a patient has is critical to determine which drug will work best and which therapies are safest in the era of personalized medicine. Key to making that judgment is an adequate tumor specimen for the pathologist to determine the tumor’s histology, a molecular description of a tumor based on the appearance of cells under a microscope. But not all specimens are perfect, and are sometimes so complex that a definitive diagnosis presents a challenge.
Stephanie Wheeler, PhD, assistant professor of health policy and management at Gillings School of Global Public Health, will receive $727,000 over five years through an American Cancer Society Mentored Research Scholar Grant.
National quality assessment programs usually measure and reward practices based on improving clinical processes such as re-hospitalization or infection rates. While this type of information is important and useful to clinicians, it doesn’t always take into account what is most important to the patient and families of the patient receiving care, such as the management of long-term symptoms or ability to conduct daily activities.
For decades, women between the ages of 21 and 69 were advised to get annual screening exams for cervical cancer. In 2009, however, accumulating scientific evidence led major guideline groups to agree on a new recommendation that women be screened less frequently: every three years rather than annually.
Different factors influence delay between diagnosis and first course of treatment for breast cancer for African-American and White women.
UNC has lost a dear colleague. Dr. Keith Amos died suddenly in Edinburgh, Scotland, while on a Dr. Claude Organ, Jr., Travel Award from the American College of Surgeons. We all hold in our thoughts his wife, Ahaji, and their three young daughters.
Albert Baldwin, PhD, William Rand Kenan Professor of Biology and associate director of UNC Lineberger Comprehensive Cancer Center, has received a one-year continuation grant from the Samuel Waxman Cancer Research Foundation.
For patients facing treatment for cancer, it is essential to understand how their symptoms will be affected. Symptoms like pain, fatigue, or nausea can result from the cancer, or from treatment side effects. The best way to collect this information is from patients themselves in research studies. But almost no drug labels in the U.S. include this information. As a result, incomplete information is available to patients and clinicians to help with treatment decisions.
Nurse Coordinators for the UNC Bone Marrow and Stem Cell Transplant Program show their support for Good Morning America anchor, Robin Roberts.
Researchers at the University of North Carolina at Chapel Hill and MIT have combined two novel technologies to create specialized versions of tiny, coated nanoparticles. Through the use of a special coating technique, the researchers were further able to customize highly reproducible nanoparticles made using the PRINT platform created at UNC, which enables scientists to manufacture particles in a near-infinite array of shapes, sizes and material compositions. The combination of these unique technologies may result in developing more effective medicines, efficient electronics and technological advances in many other fields.
It’s a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.
Jen Jen Yeh, MD, and Gary Johnson, PhD, were awarded a $326,708.00 grant from the Lustgarten Foundation for a one-year pilot study to investigate the kinome landscape of pancreatic cancer.
Humans and their pet dogs are close, so close that they both develop a type of cancer called diffuse large B-cell lymphoma. In humans it’s the most common lymphoma subtype while in dogs, it’s one of the most common cancers in veterinary oncology.
UNC women’s basketball Coach Sylvia Hatchell’s blueberry patch near Black Mountain, NC is ready for the summer picking season.
Kathy DeClue of Randolph County was featured in Family House Diaries in August 2012. She celebrated the success of a second stem cell transplant for leukemia by renewing her wedding vows with her husband of 41 years before 80 friends and family.
The first of its kind program, Single Fathers Due to Cancer, continues to gain attention through media reports.
This summer, ten boy scouts from Chapel Hill are biking across the country to raise money for UNC Lineberger Comprehensive Cancer Center. For every $15,000 raised, UNC Lineberger has agreed to send one of their pediatric oncology patients to spend a week at Victory Junction, a camp for chronically ill children.
HJ Kim, MD, associate professor in UNC’s division of surgical oncology and endocrinology, has been named as a member of the Society of Surgical Oncology's (SSO) Executive Council.
Clinical geneticist Jim Evans, MD, PhD helped to open the exhibition, Genome: Unlocking Life's Code. The high-tech, high-intensity display celebrates the 10th anniversary of production of the first complete human genome sequence also known as the genetic blueprint of the human body.
James Evans, MD, PhD, an international expert in gene patenting and genetics policy, comments on the June 13, 2013 Supreme Court ruling regarding gene patenting.
New research from the UNC School of Medicine has shown how a protein called UHRF1 “reads” the histone code in a specific way to perform an important cellular function.
The late Robert Craft Millikan will be honored with a 2013 Alumni Achievement Award from the University of California at Davis School of Veterinary Medicine during the School's commencement ceremony on June 14.
UNC women’s basketball Coach Sylvia Hatchell’s blueberry patch near Black Mountain, NC is almost ready for the summer picking season.
Four UNC School of Nursing students have been awarded American Cancer Society Graduate Scholarships in Cancer Nursing Practice. The recipients are Sean Gallagher, RN; April Lenker, RN; Melissa Matson, RN; and Lori Walker, RN.
Ten area teens will pedal with purpose this summer, riding some 3,700 miles over a 10-week period, from Maryland to Oregon. The group, dubbed “Lucky 13,” a play on the year “2013,” aims to raise $30,000 for UNC’s Lineberger Comprehensive Cancer Center, with a portion on the money going directly to serve pediatric cancer patients.
More than 15 members and associates of the UNC Lineberger Comprehensive Cancer Center presented their work to the attendees at the 2013 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
Pignone - Eligibility for aspirin for primary prevention in men increases when cancer mortality benefit added
While aspirin has been shown to be effective in preventing heart attacks in men, it also increases the risk of gastrointestinal bleeding and possibly stroke, even at low doses. As such, national guidelines suggest that aspirin be used for prevention only in men at higher risk for cardiovascular events, so that the benefits of aspirin are greater than its adverse effects.
More than 200 faculty, students and fellows gathered at the Carolina Club to hear ten-minute "TED talks" by 11 faculty recently recruited to UNC.
The study will focus on assessing the impact of a clinic-based intervention that includes having patients view a multimedia decision aid (in English or Spanish) before seeing their physician, as well as support from a bilingual patient “navigator” on completion of recommended colon cancer screening tests.
Dr. Carey Anders, MD, assistant professor of medicine, was interviewed in a new video on fertility preservation for female cancer patients produced by the American Society of Clinical Oncology. The video, titled “Discussing Fertility Preservation with Women,” was released in conjunction with ASCO updated guidelines and was shown at the 2013 ASCO annual meeting.
Cancer patients, physicians and insurers want to be sure that whatever therapy is recommended and provided to patients is based on evidence, preferably results from randomized clinical trials. But are there enough clinical trials data to provide this level of confidence?
While the mutated KRAS oncogene is associated with many cancers, it has not yet been successfully targeted by a therapeutic agent. Scientists are trying to find another way to target the gene by blocking signals from another protein downstream.
The protein GATA-3 plays an important role in mammalian immune response, but its overall function in cell development and cancer formation is not well understood. In an effort to further define the importance of GATA-3, researchers at the University of North Carolina have traced how the protein performs important functions in CD8+T-cell type of the immune system.
Smith - Worldwide cervical cancer prevention initiative announced at Women Deliver Conference in Malaysia
Cervical cancer kills an estimated 275,000 women each year, and most of these deaths could be prevented with prophylactic HPV vaccination, routine cervical cancer screening and continuity to treatment. At the Women Deliver Conference in Kuala Lumpur, Malaysia, delegates and experts from around the world announced a global call to action to combat this preventable disease through collaboration with and information sharing by the world’s governments and health agencies on May 27, 2013.
Intensity-modulated radiation therapy has become the most commonly used type of radiation in prostate cancer, but research from the University of North Carolina suggests that the therapy may not be more effective than older, less expensive forms of radiation therapy in patients who have had a prostatectomy.
Charles Perou, PhD, the May Goldman Shaw Distinguished Professor of Molecular Oncology, has been honored with the 2013 Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research. Dr. Perou is a member of UNC Lineberger Comprehensive Cancer Center.
University of North Carolina School of Medicine researchers uncover surprising insights about how nerve cells rewire themselves, shedding light on a process linked with neurodegenerative diseases and neurodevelopmental disorders like schizophrenia and autism.
Endeavors profiles the work of Nancy Klauber-DeMore, MD, professor of surgery and a member of UNC Lineberger, in unraveling the mystery of whether the gene SFRP2 suppresses tumor growth.
Barbara K. Rimer, DrPH, Dean and Alumni Distinguished Professor of the University of North Carolina Gillings School of Global Public Health, has been awarded the American Cancer Society (ACS) Medal of Honor for her "seminal cancer research efforts."
Claire Dees, MD, and Neil Hayes, MD, MPH, have been appointed as co-leaders of the Clinical Research Program at UNC Lineberger Comprehensive Cancer Center. Dr. Dees and Hayes have extensive and complementary expertise in translational and clinical research. As co-leaders of the Clinical Research Program, they will help plan the efforts of UNC Lineberger’s physician researchers to move discoveries into innovative trials of new therapeutic approaches.
Q&A with UNC Lineberger members James P. Evans, MD, PhD; David Ollila, MD; Paola Gehrig, MD; and Keith D. Amos, MD, FACS.
Jennifer Smith, PhD, MPH, research associate professor at the UNC Gillings School of Global Public Health and member of the UNC Lineberger Comprehensive Cancer Center, says that lack of awareness and stigma about the illness hinders prevention of the disease.
Patients must take a larger role in participating in and assisting in determining priorities for medical research, according to an editorial published in an upcoming issue of the Journal of the American Medical Association.
Hy Muss, MD, Director, Geriatric Oncology Program discusses evaluation tools for treating older patients on OncLive.
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
In Kenya, women face a cervical cancer mortality rate that is approximately 10 times as high as in the United States. A study by researchers at the University of North Carolina at Chapel Hill suggests that training women to self-collect genital samples to test for human papillomavirus (HPV), the causative agent of cervical cancer, can increase the coverage rates of cervical cancer screening. Higher screening coverage helps increase rates of detection of cervical lesions and ultimately treatment of the disease.
Raj Pruthi, MD, Chief of Urologic Surgery for the Urologic Oncology Program spoke at the annual meeting of the American Urological Association (AUA) in San Diego, California.
Close to 450 people attended the 37th annual UNC Lineberger scientific symposium April 29 and 30, 2013. Symposium co-chairs were Jonathan Serody, MD, PhD, Elizabeth Thomas Chair of Medicine, and Jenny Ting, PhD, UNC Alumni Distinguished Professor of Microbiology and Immunology. Both spoke at the symposium.
Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease. An international team, led by scientists at the University of North Carolina Lineberger Comprehensive Cancer Center, reports pre-clinical research showing improved efficacy of a PEGylated liposomal (encapsulated) anti-cancer agent compared with a non-liposomal formulation of the same drug in an intracranial model of breast cancer. Their results were published in the May 1, 2013 issue of PLOS ONE.
Associate professor Deborah Mayer, PhD, RN, AOCN, FAAN and member of UNC Lineberger has been selected as an Extraordinary Nurse Leader by Yale University, the first independent university-based nursing school established in the United States. As part of its 90th anniversary celebration, Yale School of Nursing has selected 90 alumni who “embody the School’s mission of advancing better health care” to be honored at a ceremony in October 2013.
Kurt Ribisl, PhD, head of Cancer Prevention and Control Program at the UNC Lineberger Comprehensive Cancer Center, was interviewed by National Public Radio on New York City's proposal to raise the legal age to buy cigarettes to 21.
A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.
Dr. Harold E. Varmus, director of the National Cancer Institute at the National Institutes of Health and co-winner of the 1989 Nobel Prize in Physiology or Medicine for the discovery of the cellular origin of retroviral oncogenes, was invited to campus by UNC’s Nobel Laureate Dr. Oliver Smithies.
Sethi, MacNevin, Feng come out on top at 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum
On Friday, April 19, from 2 p.m. to 4 p.m. in the MBRB at the School of Medicine, 44 university postdoctoral fellows gathered for a poster forum to present their research findings.
A team from the UNC Bone Marrow and Stem Cell Transplant Program headed up by Tippu Khan, PharmD, BCOP and Nicole Frazier, RN, BSN participated in an epic journey which included leaping over fire, trekking through waste-high mud, tossing spears, dodging attacks and most of all braving near freezing temperatures in the driving rain. What is all this about? It's the Spartan Race, an event of pure primitive craziness that promises it's participants an experience they'll never forget.
Kerry Steven Bloom, Thad L. Beyle Distinguished Professor of biology at the University of North Carolina at Chapel Hill, has been elected to the American Academy of Arts and Sciences, one of the nation’s oldest and most prestigious honorary societies and a leading center for independent policy research.
Health reporter for the New York Times, Jane Brody, features the Single Fathers Due to Cancer program.
Transcription factors regulating blood oxygen linked to melanoma metastases
A Dare County real estate agent refuses to let a breast cancer diagnosis and its treatment detract from her trademark sense of humor and constant outreach to others.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted about a case before the U.S. Supreme Court involving Myriad Genetics attempts to patent two human genes related to breast and ovarian cancer.
Researchers at the University of North Carolina at Chapel Hill School of Medicine have "rationally rewired" some of the cell's smallest components to create proteins that can be switched on or off by command. These "protein switches" can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease.
UNC Lineberger was well represented at the American Association for Cancer Research Annual Meeting held in Washington, DC.
A team led by Dr. Stanley Lemon discovered that hepatitis A virus does not have an envelope when found in the environment, but acquires one from the cells that it grows in within the liver. It circulates in the blood completely cloaked in these membranes.
Lisa A. Carey, MD, Medical Director of the UNC Breast Center, the Chief of Hematology/Oncology, the Physician-in-Chief of the N.C. Cancer Hospital, and UNC Lineberger member, discusses the use of everolimus in the metastatic and adjuvant settings of breast cancer.
Neil Hayes, MD, MPH, associate professor in UNC's Division of Hematology and Oncology, presented on the patterns of genomic alterations in head and neck squamous cell carcinomas (HNSCC) at the AACR's 2013 Annual Meeting in Washington, D.C.
Satish Gopal, MD, MPH, assistant professor in the divisions of hematology/oncology and infectious diseases at the UNC School of Medicine, describes his experiences in assisting Kamuzu Central Hospital in the creation of a lab to diagnose and research cancer in Malawi.
The accomplishment provides a much-needed resource for scientists eager to uncover the true mechanisms of human stem cell biology. It also enables them to explore new tactics to treat inflammatory bowel disease or to ameliorate the side effects of chemotherapy and radiation, which often damage the gut.
Cancer patients at UNC and Duke have one less thing to worry about, thanks to the recently launched Cancer Pro Bono Legal Project. This cutting-edge collaboration among the law schools and cancer centers at the two universities and the North Carolina Bar Association offers free legal services to local cancer patients. The project has won funding from the Kenan Biddle Foundation as well as the North Carolina Bar Foundation.
Hyman B. Muss, MD, Professor of Medicine, Director of Geriatric Oncology, Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill School of Medicine, discusses the need for a team environment when treating an older patient at OncLive.
African American men on average wait a week longer than their Caucasian counterparts between the initial diagnosis of prostate cancer and treatment, according to University of North Carolina researchers.
Men who have dependent children and whose spouses or partners died from cancer are an overlooked population. These fathers face unique challenges not addressed by traditional grief support groups that often attract an older, female population.
NBC's Today Show spotlighted the first-of-its-kind program designed to help single dad's who have lost a spouse to cancer. NBC’s Dr. Nancy Snyderman reports on the group's efforts.
Research conducted in fruit flies at the University of North Carolina School of Medicine has pinpointed a specific DNA sequence that both triggers the formation of the “histone locus body” and turns on all the histone genes in the entire block.
Craven County resident, Cindy Sills, has alveolar rhabdomyosarcoma, a cancerous tumor of the muscles that are attached to bones. She and her husband work to raise awareness of rare rare soft-tissue cancer.
James Evans, director of UNC's Clinical Cancer Genetics program and UNC Lineberger member, says it is time for a public health strategy that focuses on genetic testing of healthy adults.
Barbara Fredrickson, professor of psychology and UNC Lineberger member, writes in an editorial in the New York Times that the physical and psychological tools that allow us to relate to others can diminish with lack of use.
Oliver Smithies did not set out to become one of the world’s foremost pioneers in cancer research. He merely had a question that needed answering.
“It’s a lifesaver.” That’s how Frances Patterson, a breast cancer patient, describes the therapy she receives for lymphedema through the UNC Comprehensive Cancer Support Program.
Researchers at the University of North Carolina at Chapel Hill have discovered that a protein found in the cells surrounding pancreatic cancers play a role in the spread of the disease to other parts of the body.
Ribisl predicts that new regulations preventing the open display of cigarettes in stores could lead to a reduction in smoking over time.
Debbie Dibbert, Director of External Affairs at UNC Lineberger, was named as a Hometown Hero by WCHL 97.9 and Chapelboro.com.
Jenny Ting, PhD, W.R. Kenan, Jr. Distinguished Professor of Microbiology and Immunology, has been awarded a 2013 University Award for the Advancement of Women.
Michael Pignone, MD, MPH, Professor of Medicine and Division Chief of General Medicine and Epidemiology, has been named director of the UNC Institute for Health Care Quality Improvement, which aims to establish UNC as the leading academic medical center in the area of clinical quality improvement. The new institute is a product of the UNC School of Medicine’s Strategic Plan.
For the first time, a population-based study of a human papillomavirus (HPV) vaccine has proven that the vaccine is effective in reducing the incidence of genital warts.
Two members of the UNC Lineberger Comprehensive Cancer Center have been elected as 2013 Fellows of the American Academy of Microbiology (AAM), the honorific leadership group within the American Society for Microbiology (ASM).
A study by Karyn Stitzenberg, MD, MPH, assistant professor of surgery and member of the UNC Lineberger Comprehensive Cancer Center, shows that surgical oncologists comprise only a small portion of the number of surgeons who perform cancer surgery.
The School ranked 1st in Primary Care and 22nd in Research overall in the 2014 U.S. News & World Report Best Medical School Rankings. Family Medicine, Rural Medicine and AIDS were also listed as top ten specialties.
To meet a growing need for nurses with advanced training, the University of North Carolina and five other UNC-system schools will offer a doctorate in nursing this fall. The News and Observer article discusses the need and role that will be filled by the new Doctors of Nursing Practice.
The journal Oncology's online Cancer Network profiled an address given by Hyman Muss, MD, professor of medicine, at the 30th Annual Miami Breast Cancer Conference in March.
Researchers at the University of North Carolina at Chapel Hill have discovered how helper molecules, or chaperones, aid in the RNA folding process, resolving a fundamental conundrum about how these important biological molecules work.
New chemical probe provides tool to investigate role of malignant brain tumor domains in chromatin structure and regulation
In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC Eshelman School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain. The probe, named UNC1215, will provide researchers with a powerful tool to investigate the function of malignant brain tumor (MBT) domain proteins in biology and disease.
Experts from the UNC School of Medicine and the UNC Gillings School of Global Public Health propose that screening healthy adults for preventable diseases such as colorectal cancer, breast cancer, and several catastrophic blood vessel disorders, among others, could potentially prevent these diseases.
A UNC Lineberger-affiliated program that provides HIV and cervical cancer testing in Malawi and Zambia was featured on the Raleigh-Durham ABC affiliate.
Could glowing rodents come to the aid of cancer researchers … and patients?
Head and neck squamous cell carcinoma (HNSCC) is the seventh most common form of cancer in the United States, but other than an association with the human papillomavirus, no validated molecular profile of the disease has been established. By analyzing data from DNA microarrays, a UNC-led team has completed a study that confirms the presence of four molecular classes of the disease and extends previous results by suggesting that there may be an underlying connection between the molecular classes and observed genomic events, some of which affect known cancer genes. The clinical relevance of the classes and certain genomic events was demonstrated, thus paving the way for further studies and possible targeted therapies.
James Evans, Bryson Distinguished Professor of Genetics and Medicine, was interviewed about his work as principal investigator on the NCGENES Study with WCOM 103.5's Radio In Vivo.
More than 70 kidney cancer patients and their families participated in the Kidney Cancer Association’s patient and survivor conference held at the Friday Continuing Education Center in Chapel Hill on February 23.
Triple-negative breast cancers are more biologically diverse than previously believed and classification should be expanded to reflect this heterogeneity, according to University of North Carolina researchers.
The publication names the cancer center as one of the top 100 oncology programs in the nation.
Inflammatory response plays a major role in both health protection and disease generation. While the symptoms of disease-related inflammatory response have been know, scientists have not understood the mechanisms that underlie it.
The article profiles Russell Tatum, a father who found emotional support for himself and his family through the UNC Lineberger-supported group designed for fathers who have lost a spouse to cancer.
Michael Pignone will join fellow experts in evidence-based medicine from many health-related fields to rigorously review existing peer-reviewed evidence and evaluating the benefits and harms of preventive services.
Preclinical study shows potential of new technologies to detect response to cancer therapy earlier
A set of towlettes developed by two researchers at Carolina can safely remove difficult-to-clean anticancer drugs commonly found on surfaces in hospitals, pharmacies, clinics and labs. The product, called Hazardous Drug Clean – or HDClean – addresses the growing concern regarding the safety of health care workers who frequently handle these potentially dangerous drugs.
The Triangle Business Journal has named two UNC Lineberger members as finalists for the 2013 Health Care Heroes Awards.
North Carolina’s community colleges are important settings for educating and training our citizens. Can they also play a role in preventing cancer? A group of UNC researchers recently looked into the question of whether community colleges could spread the latest evidence-based cancer and wellness information to the thousands of employees and students of the state’s community college system.
Leah Ranney, PhD, associate director of the UNC Tobacco Prevention and Evaluation Program, and Adam Goldstein, MD, professor in UNC Family Medicine and director of the Tobacco Prevention and Evaluation Program, published the following editorial on the social benefits of anti-smoking policies and tobacco-use prevention programs:
Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) hide within the worldwide human population. While dormant in the vast majority of those infected, these active herpesviruses can develop into several forms of cancer. In an effort to understand and eventually develop treatments for these viruses, researchers at the University of North Carolina have identified a family of human genes known as Tousled-like kinases (TLKs) that play a key role in the suppression and activation of these viruses.
Ethan Basch, MD, MSc, Director of Cancer Outcomes Research at the UNC Lineberger Comprehensive Cancer Center, has been appointed by the Director of the National Cancer Institute to serve on the Board of Scientific Advisors (BSA).
What’s most important to a man as he decides whether or not to undergo prostate-specific antigen- PSA- screening for prostate cancer? What does he value most about the screening? And what’s the best way to present the information to help him make an appropriate decision for himself?
In a study published in the January 18 issue of Cell, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have developed a new method to visualize aging and tumor growth in mice using a gene closely linked to these processes.
More than 150 physicians and patients gathered February 6th and 7th to learn more about melanoma. Melanoma Patient Day, February 6, was a half-day symposium sponsored by the Melanoma Research Foundation, the UNC Division of Surgical Oncology and the UNC Department of Dermatology. Meeting co-chairs were Drs. David Ollila, professor of surgery, and Nancy Thomas, Robert Alan and Irene Briggaman Distinguished Professor of Dermatology.
Worldwide, many strains of the bacterium Staphyloccocus aureus are already resistant to all antibiotics except vancomycin. But as bacteria are becoming resistant to this once powerful antidote, S. aureus has moved one step closer to becoming an unstoppable killer. Now, researchers at the University of North Carolina at Chapel Hill have not only identified the mechanism by which vancomycin resistance spreads from one bacterium to the next, but also have suggested ways to potentially stop the transfer.
UNC researchers find a way to unlock the secrets of DNA’s dark matter.
A new study from the University of North Carolina published January 25, 2013 in the journal Genome Medicine reveals the huge diversity of U.S. biobanks and also raises questions about the best way to manage and govern them
The Triad Golfers Against Cancer has awarded two grants to researchers at the UNC Lineberger Comprehensive Cancer Center totaling $65,000.
A University of North Carolina School of Medicine study may have implications for thwarting the effects of bioterrorism attack with lethal microbes, as well as finding a way to save people in septic shock, an overwhelming bacterial infection of the blood.
The Scientist Magazine has featured recent research by Timothy Gershon, MD, PhD, on the link between brain tumors and glycolysis.
The 2012 University Cancer Research Fund Innovation Awards recognize six University of North Carolina researchers for groundbreaking cancer research. The UCRF Innovation Awards are designed to support innovation, collaboration and cancer-focused science across a broad spectrum of the cancer-research community at UNC.
Norman Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Deputy Cancer Center Director, discussed the development of a mouse model to study aging and cancer with WUNC's Frank Stasio.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, spoke to National Public Radio's All Things Considered about the need to find a balance between making genetic data available to researchers and protecting patient privacy.
Dr. Qi Zhang receives the 2013 Basil O’Connor Starter Scholar Research Award from the March of Dimes Foundation.
Joseph DeSimone, PhD, was awarded the 2012 Watson Chubb Award for Innovation from the Sigma Xi, The Scientific Research Society. The award honors creativity among scientists and engineers.
A 2009 survey by UNC faculty of North Carolina middle and high schoolers found that 79 percent support smoke-free areas and other smoking bans.
The best approach to detecting cervical cancer in HIV-positive women living in research limited countries such as those in Sub-Saharan Africa combines commonly used testing methods tailored to local levels of development and medical infrastructure, according to a study by researchers from and the University of Witwatersrand in South Africa and the University of North Carolina.
Jenny Ting, PhD, Alumni Distinguished Professor in UNC’s Department of Microbiology and Immunology and member of UNC Lineberger, has been awarded the American Association of Immunologist’s Life Technologies Meritorious Career Award for 2013.
This month's focus is on the ever-popular mode of entertainment enjoyed throughout the centuries: the theater. Keith Burridge, a Kenan Professor of Cell Biology and Physiology, is also a playwright. His most recent play, The Art of Deception, is based on a true story of a dutch painter, Han van Meegeren.
CHAPEL HILL, N.C. – Research findings from the University of North Carolina School of Medicine are shining a light on an important regulatory role performed by the so-called dark matter, or “junk DNA,” within each of our genes.
Endeavors: Yang finds new link between health and connectivity to friends, family, and social groups
From UNC Endeavors - The arthritis and chronic back pain are so intense that the patient can barely get through the day. The patient’s blood work reveals that his body is in a state of chronic inflammation, a sign that his immune system is working too hard. Doctors prescribe medication, which helps a little, but it won’t address one contributing factor that sociologist Yang Yang says doctors aren’t trained to consider.
The Komen Foundation named Hyman B. Muss, MD, Professor of Medicine and the Director of the Geriatric Oncology Program at University of North Carolina Lineberger Comprehensive Cancer Center in Chapel Hill as one of two recipients of their Brinker Ward in 2012.
Satish Gopal, MD, MPH, assistant professor in the divisions of hematology/oncology and infectious diseases at the UNC School of Medicine, has been awarded a 2012 AIDS Malignancy Consortium (AMC) fellowship. The fellowship helps foster the careers of new and junior investigators whose work involves clinical research trials on HIV-associated malignancies in resource-limited settings.
Wang discovers information from outside the genome influences stem cell differentiation, cancer development
Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.
Use the links below to find the news archives.
N.E.D. - a rock band comprised of gynecologic oncology physicians - was featured in the New York Times' health and science blog.
Dr. Carey talks about the importance of cancer research and her new role as Chief of the Division of Hematology and Oncology and Physician-in-Chief of the N.C. Cancer Hospital.
The American Association for Cancer Research and Kure It have announced that William Y. Kim, MD, will receive a 2012 AACR-Kure It Grant for Kidney Cancer Research.
Nikolay Dokholyan, PhD, Professor of Biochemistry and Biophysics and member of the UNC Lineberger Comprehensive Cancer Center, was elected as a 2012 Fellow of the American Physical Society. The Dokholyan lab studies the physical nature of interactions between atoms, molecules, cells, and organisms. The underlying question throughout their research is how these interactions shape the complex organization, behavior, and evolution of biomolecules and organisms.
Hepatitis C virus has evolved to invade and hijack the basic machinery of the human liver cell to ensure its survival and spread. Researchers at the University of North have discovered how hepatitis C binds with and repurposes a basic component of cellular metabolism known as a microRNA to help protect and replicate the virus.
The UNC Global Oncology Program held its third annual retreat on December 14 at the Friday Center. Led by Dr. Blossom Damania, Director of the UNC Lineberger Global Oncology Program, and Dr. Dirk Dittmer, Program Resource Director for the program, close to 80 program members from the UNC Center for AIDS Research and UNC Lineberger shared their research.
For Dr. Neil Hayes “the best part of being a scientist is the people. Here at UNC, it’s the leadership we have for the cancer center in clinical fields, the wonderful scientists across the country who we collaborate with, and our patients.”
Dr. Lisa Carey, Marilyn Jacobs Preyer Distinguished Professor in Breast Cancer Research, and Barbara Martin, Health-e-NC Project Director, will discuss surviving breast cancer on the next episode of UNC’s Your Health with Adam & Cristy.
ABC 11 recently featured the UNC Comprehensive Cancer Support Program's Caregiver Support Group.
The UNC Lineberger Geriatric Oncology Program held its third annual retreat on November 29 at the Friday Center. Program members presented research and heard scientific presentations from colleagues at Duke and Wake Forest Universities. The group then discussed areas of possible collaboration.
Kurt Ribisl, PhD, has been appointed to lead the Cancer Prevention and Control Program at the UNC Lineberger Comprehensive Cancer Center.
An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively make designer drugs that hit multiple protein targets at once.
Brook Zickus’ wedding bouquet featured an unusual “something blue”: a UNC Lineberger ribbon-foot pin.
Basch discusses the value of patient-reported data in comparative effectiveness research in two webinars Dec. 11 and 12
Ethan Basch, MD, Director of the Cancer Outcomes Research Program at UNC Lineberger Comprehensive Cancer Center, will be speaking in two webinars on comparative effectiveness on Tuesday, Dec. 11 and Wednesday, Dec. 12.
The annual compilation of The Best Doctors in America® includes more than 60 physicians affiliated with the University of North Carolina’s Lineberger Comprehensive Cancer Center.
Yang Yang, PhD, associate professor of sociology and member of UNC Lineberger, was quoted about a Journal of Urology study that found that men have a higher death rate from cancer.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, was quoted on National Public Radio's All Things Considered discussing a report in American Journal of Human Genetics finding that healthy people have many genetic mutations.
Terry Magnuson served on an Institute of Medicine commission tasked to review the progress of California’s state-funded regenerative medicine initiative focused on stem cell research.
Chapel Hill, NC – Norman E. “Ned” Sharpless, MD, has been appointed Deputy Director of the UNC Lineberger Comprehensive Cancer Center. Dr. Sharpless is the Wellcome Distinguished Professor in Cancer Research, professor of medicine and genetics.
Federico Innocenti, MD, PhD, received the 2013 Leon I. Goldberg Young Investigator Award from the American Society for Clinical Pharmacology and Therapeutics. Innocenti, associate director for oncology research in the UNC Institute for Pharmacogenomics and Individualized Therapy and a member of UNC Lineberger, was recognized for his work in individualizing therapy for cancer patients.
The American Association for the Advancement of Science has awarded three UNC Lineberger Comprehensive Cancer Center members the distinction of AAAS 2012 Fellow. The three were among four UNC School of Medicine Faculty honored.
Stacey Anderegg is an Hematology/Oncology Infusion Nurse at the N.C. Cancer Hospital. In her life outside the hospital, Stacey is a vocalist with a 7 woman a cappella group called "Stella."
Dr. Lisa Carey, MD, medical director of the UNC Breast Center and associate director for clinical science at UNC Lineberger Comprehensive Cancer Center, spoke to MedPage Today about a recent Centers for Disease Control study that reported that black patients had a 41 percent higher mortality than their white counterparts, despite having a lower incidence of the disease.
The protein Ras plays an important role in cellular growth control. Researchers have focused on the protein because mutations in its gene are found in more than 30 percent of all cancers, making it the most prevalent human oncogene.
Chapel Hill, NC – In a paper published in the Nov. 21 issue of Cell, a team led by Mauro Calabrese, a postdoctoral fellow at the University of North Carolina in the lab of Terry Magnuson, chair of the department of genetics and member of the UNC Lineberger Comprehensive Cancer Center, broadens the understanding of how cells regulate silencing of the X chromosome in a process known as X-inactivation.
Neil Hayes, MD, MPH, talks to North Carolina Now about new research into lung cancer. The interview aired on the show's Nov. 12, 2012 broadcast.
Chapel Hill, NC – Ethan Basch, MD, has joined the Lineberger Comprehensive Cancer Center at the University of North Carolina School of Medicine. Basch will be an associate professor of medicine and director of the cancer outcomes research program.
Two UNC Board of Trustees members and longtime UNC Lineberger supporters were among the seven honored with the William Richardson Davie Award. The Davie Awards are the highest honor bestowed by the UNC Board of Trustees.
The 2012 Comprehensive Cancer Support Program Support Week was a huge success. Hundreds of patients and caregivers learned about and participated in activities highlighting the many support services of the Comprehensive Support Program during CCSP Support Week 2012.
UNC Lineberger Comprehensive Cancer Center and UNC Cancer Care honored four employees with 2012 Excellence Awards.
Andrew F. Olshan, PhD, has been appointed Associate Director of Population Sciences at UNC Lineberger Comprehensive Cancer Center. This senior leadership position is responsible for overseeing the development of population-based cancer research and its integration throughout the Cancer Center programs. The position also oversees several Cancer Center core resources as well as two established scientific programs, Cancer Epidemiology and Cancer Prevention and Control. Dr. Olshan will continue to serve as head of the Cancer Epidemiology Program and directs two cores, the Biospecimens Processing Facility and Rapid Case Ascertainment Core.
Valerie King is living the teenage dream, she's in the running for homecoming queen. While it's tough competition for the crown, it's nothing compared to the battle she's been fighting for the past year.
Shelley Golden, MPH, and Jo Anne Earp, ScD, co-wrote an article that received the Lawrence W. Green Paper of the Year Award at the 63rd annual meeting of the Society for Public Health Education (SOPHE), held Oct. 25-27 in San Francisco.
Lilly Oncology on Canvas Art Exhibit on display in the N.C. Cancer Hospital Lobby November 7-21, 2012
UNC Lineberger Comprehensive Cancer Center is hosting the Lilly Oncology on Canvas Exhibition in the lobby of the N.C. Cancer Hospital.
The chief of cardiology in the University of North Carolina School of Medicine and member of UNC Lineberger has been elected president of the Association of Professors of Cardiology.
UNC researchers discover the first link between epigenetic tags—the chemicals that orchestrate how our genes are expressed and our health maintained or derailed.
A new website for Single Fathers Due to Cancer has been launched as a way to help fathers more easily find resources and support.
Dr. Lisa Carey was featured by the Susan G. Komen Foundation as part of its 31 Days of Impact series that profiled men and women who are inspirational in the fight against breast cancer.
Genetic Engineering and Biotechnology News interviwed Howard McLeod, PharmD, about the role of physicians and insurance companies in gauging chemotherapy dosages in an article titled "Chemotherapy for the 21st Century" published Oct. 31, 2012.
Linda Van Le, MD, professor of gynecologic oncology and member of the UNC Lineberger Comprehensive Cancer Center, has been appointed the Leonard Palumbo Distinguished Professor of Gynecologic Oncology. This professorship was established in 1986 in honor of Dr. Leonard Palumbo. Because of Dr. Palumbo's long standing commitment to gynecologic oncology it was the family's wish that this professorship be designated as a professorship in gynecologic oncology. Dr. Wesley Fowler, Jr. held the professorship during his nearly forty years of dedicated service to the UNC Department of Obstetrics and Gynecology.
Mark C. Weissler, MD, FACS, was elected vice-chair of the Board of Regents of the American College of Surgeons (ACS) during the organization’s 2012 Clinical Congress in Chicago on Sept 30.
Lawrence B. Marks, MD, has been elected to a two-year term on the Board of Directors of the American Society for Radiation Oncology (ASTRO).
The Raleigh News and Observer interviewed Leslie Parise, PhD, professor and chair of the department of biochemistry, and Tina Leisner, PhD, a UNC research associate in biochemistry, about their research into the linkage between breast cancer and the protein CIB1.
Keith Amos, MD, FACS, was interviewed by UNC-TV’s Black Issues Forum on community education about breast cancer in the African American community on Sunday, Oct. 28.
Look at a typical directory of cancer support groups and you’ll find listings for cancer types, survivorship, and coping. But not too many lists include groups for caregivers.
There are Top 20 lists for music, books and for articles written about lay health advisors, as reported by the BioMedLib “Who is Publishing in My Domain?” journal.
Located at the center of campus, the new Genome Sciences Building will help researchers unlock the underlying mechanisms of cancer, in addition to providing space for other groundbreaking research.
Asheville artist Ann Hartline was featured in Family House Diaries in July 2011. Despite new medical challenges over the past year, Ann celebrated five years of living life large with metastatic breast cancer.
Close to 150 faculty and postdoctoral fellows gathered at the Kenan Center for the 37th annual UNC Lineberger Postdoc-Faculty Research Day
This year’s speaker was Dr. Brooke McCartney, associate professor in the department of biological sciences at Carnegie Mellon University. She completed her postdoc training in the lab of Dr. Mark Peifer.
Ronald Chen, MD, MPH, assistant professor of Radiation Oncology in the UNC School of Medicine and Bryce Reeve, PhD, associate professor of Health Policy and Management in the Gillings School of Global Public Health have been awarded a four-year, $1,124,226 grant by the National Cancer Institute (NCI). This grant supplements a parent study funded by the Agency for Healthcare Research and Quality (AHRQ) to monitor the recovery, mental well-being and quality of life of prostate cancer patients during the two years following treatment. Both researchers are members of UNC Lineberger Comprehensive Cancer Center.
Patient perspective key to adequate evaluation of cancer treatment
Satish Gopal, MD, MPH, assistant professor in the division of hematology/oncology and infectious diseases at the UNC School of Medicine, has received a five-year International Research Scientist Development Award (IRSDA) from the Fogarty International Center of the National Institutes of Health.
Election to the IOM is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.
A brilliant and beloved scientist has left us too early. Dr. Robert Millikan, Barbara Sorenson Hulka Distinguished Professor of Cancer Epidemiology, died Sunday, October 7. He was 55.
William Valdar, PhD, assistant professor of genetics, has received a 5-year, $1.4 million grant from the National Institute of General Medical Sciences (part of the National Institutes of Health), to develop statistical methods and software to support the design and analysis of experiments that use the Collaborative Cross, a “library” of genetic diversity that scientists believe can help fast-track important discoveries about genetics and disease into new discoveries, tests, and treatments that impact human health.
Andrew Wang, MD, assistant professor of radiation oncology, has been awarded a $50,000 one-year grant from the Lung Cancer Research Foundation.
Chapel Hill, NC – Christophe Guilluy, PhD, Wenjin Liu, PhD and JinZhu Duan, PhD are the first, second, and third place recipients of the Joseph S. Pagano Award for a paper by a postdoctoral fellow published in 2011.
The North Carolina Biotechnology Center recently awarded the Society for Translational Oncology (STO) $5,000 to be used for the organization's annual meeting. This year's meeting "Personalizing Cancer Diagnosis and Treatment 2012" will be held October 20-21 at UNC Lineberger.
WCHL named UNC Lineberger director Shelley Earp, MD, the Village Pride Award Honoree for October 2, 2012. Each weekday the station selects a Hometown Hero who goes “over and above the call of duty,” exemplifying excellent service and dedication to others in the community.
Chapel Hill, NC – More than 50 Chapel Hill and Carrboro businesses and community groups are turning the towns pink during the months of September and October to raise funds for UNC Lineberger Comprehensive Cancer Center and its Comprehensive Cancer Support Program.
New research from UNC has established the first link between the two most fundamental epigenetic tags -- histone modification and DNA methylation -- in humans.
DALLAS -- An American clinician-scientist and an Israeli researcher whose work has led to more personalized treatments for breast cancer are being honored as this year’s winners of the prestigious Susan G. Komen for the Cure® Brinker Awards for Scientific Distinction in Basic Science and Clinical Research, the highest awards of merit given by the world’s leading breast cancer organization.
Blossom Damania, PhD, and Dirk Dittmer, PhD, both have lived all over the world, where they saw firsthand the global burden of cancer. Both are professors of microbiology and immunology in the UNC school of Medicine and members of UNC Lineberger.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, provided his perspective on a HuffPost Live broadcast that aired on September 24, 2012.
Team identifies genetic causes and similarity to ovarian cancer
Carey named Division Chief of Hematology-Oncology and Physician-in-Chief of the N.C. Cancer Hospital
Chapel Hill - Lisa A. Carey, MD, has been appointed Chief of the Division of Hematology and Oncology at the University of North Carolina School of Medicine and Physician-in-Chief of the N.C. Cancer Hospital.
Chapel Hill, NC – The cost of sequencing the entire human genome, or exome – the regions of the genome that are translated into proteins that affect cell behavior – has decreased significantly, to the point where the cost of looking at the majority of a patient’s genomic data may be less expensive than undertaking one or two targeted genetic tests.
Chapel Hill, NC –Researchers have long known that individual diseases are associated with genes in specific locations of the genome.
Preclinical testing a necessary step in drug development
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted in NPR's second story in its "$1,000 Genome" series, which aired today.
UNC Lineberger faculty co-author review article on adjuvant chemotherapy in women 70 years of age and older
Chapel Hill, NC – A mysterious form of cell death, coded in proteins and enzymes, led to a discovery by UNC researchers uncovering a prime suspect for new cancer drug development.
Dr. Angelique Whitehurst, assistant professor of pharmacology, was awarded a 2011 Innovative Research Grant from Stand Up to Cancer, the scientific partner of the American Association of Cancer Research.
Changes in DNA that are important to the initiation and progression of lung cancer also identified by NIH-supported researchers
Wanda Wooten talks with NBC 17 about the day she was diagnosed with ovarian cancer and her treatment and offers encouragement to other women facing ovarian cancer.
The WTX gene is mutated in approximately 30 percent of Wilms tumors, a pediatric kidney cancer. Like many genes, WTX is part of a family. In this case, WTX has two related siblings, FAM123A and FAM123C.
GeneCentric now has two separate exclusive licenses to diagnostic technologies from the University of North Carolina at Chapel Hill. The company was co-founded in 2011 by UNC Lineberger researchers Drs. Charles Perou and Neil Hayes, who discovered molecular signatures critical in distinguishing clinically relevant subtypes of lung cancer.
UNC-Chapel Hill rose to ninth from 16th among leading private and public research universities for the level of federal funding ($545.99 million) devoted to research and development in all fields during fiscal 2010.
UNC Head Basketball Coach Roy Williams and UNC Lineberger physician-scientist Kim Rathmell, MD, PhD, were featured speakers at the American Cancer Society’s Cancer Action Network breakfast, held August 24th in Research Triangle Park.
Kayaking and rock climbing aren’t usual clinical activities for UNC Lineberger medical oncologist Dr. Juneko Grilley-Olson and nurse practitioner Elizabeth Sherwood, but they were during the time that each volunteered for a First Descents camp week for young adult cancer survivors.
Chapel Hill, NC – A laboratory study led by UNC medical oncologist Stergios Moschos, MD, demonstrates how a new targeted drug, Elesclomol, blocks oxidative phosphorylation, which appears to play essential role in melanoma that has not been well-understood.
Chapel Hill, NC – Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime, and ultimately affect their long-term survival.
The V Foundation for Cancer Research, one of the nation’s leading cancer research foundations, has awarded a $600,000 grant to a UNC Lineberger team.
A Randolph County woman with leukemia receives stem cells from her youngest brother in hopes of restoring her health and returning to work as a baker.
Hy Muss, MD, and Debra Bynum, MD, co-authored an editorial in the July 20, 2012 issue of the Journal of Clinical Oncology.
A UNC-led team of scientists describes the function of a previously uncharacterized protein that dramatically influences inflammation.
Chapel Hill, NC – Carmina G. Valle, MPH, is the recipient of the first Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences.
Joseph DeSimone, PhD, Chancellor's Eminent Professor of Chemistry, gave an interview to EarthSky regarding his green inventions, his current work and the future of science.
Nick McCrory, the son of Ana and Doug McCrory, won a bronze medal in the Olympic men’s 10-meter synchronized diving competition with partner David Boudia. Nick’s mother, Ana, works in the UNC Lineberger Tissue Culture Facility.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted in an article on NPR's website discussing a recent request by a genetic test maker for the Food and Drug Administration to approve its personalized DNA test.
Life is full of choices, and even cells come to a fork in the road. They have to decide what to do about damage to their DNA: repair the damage, force the damaged cell to die, or allow the damage to transform the cell to a tumor cell.
Three UNC graduate students were awarded International Predoctoral Fellowships by the Howard Hughes Medical Institute. Onur Dagliyan, Alakananda Das, and Mira Pronobis each received a $43,000 fellowship.
Three UNC Lineberger researchers are collaborating on a project recently awarded more than $3.3 million over five years from the National Institutes of Health’s National Heart, Lung, and Blood Institute.
Vaccines against human papillomavirus (HPV) are now recommended by the Centers for Disease Control and Prevention for both teenage boys and girls. The vaccine protects against the two most common types of the virus that cause cervical cancer: HPV 16 and 18. Is there a chance that the increased number of people vaccinated might result in an increase of other types of HPV that cause cancer?
Ana McCrory of the Tissue Culture Facility will be making a special trip to London in July. She, her husband, Doug, their son, Lucas, and other family members are traveling to cheer on her son, Nick, who is a member of the 11-member US diving team for the 2012 Summer Olympics.
Dittmer selected to serve as chair of AIDS-Associated Opportunistic Infections and Cancer Study Section
Dirk Dittmer, PhD, professor of microbiology and immunology, has been selected to serve as chair of the AIDS-Associated Opportunistic Infections and Cancer Study Section, for the Center for Scientific Review, a program of the National Institutes of Health.
RALEIGH, NC – Crown Imports announced today that the highly successful “Corona Cares” charitable donation program in North Carolina will kick off on August 1 to benefit patient and family support programs at the N.C. Cancer Hospital. Over the past two years, “Corona Cares” has provided more than $210,000 for these programs.
The Cancer Genome Atlas generates genomic data for colon and rectal cancers that point to potential targets for treatment.
Rachel Roper, PhD, Associate Professor of Microbiology & Immunology at East Carolina’s Brody School of Medicine has been granted a patent for her discovery of a poxvirus gene that, when deleted, significantly weakens the vaccine virus while simultaneously increasing immune responses to it.
Overall, eleven specialties at UNC Hospitals were recognized as nationally ranked or high performing by U.S. News & World Report in its annual "America's Best Hospitals" issue.
The University of North Carolina at Chapel Hill’s Frank Hawkins Kenan Institute of Private Enterprise has appointed Joseph M. DeSimone as its new director.
Keith Amos, MD, assistant professor of surgery at UNC-Chapel Hill, is quoted in an ABC News feature discussing a new study about partial breast removal surgery to treat cancer.
John Strader, PA-C with the hematologic malignancies program, was honored as the 2012 Man of the Year by the Leukemia & Lymphoma Society, North Carolina chapter, raising over $30,000 for the organization.
Chapel Hill - From the air, the twists and turns of rivers can easily be seen. In the body, however, tracing the twists and turns of blood vessels is difficult, but important. Vessel “bendiness” can indicate the presence and progression of cancer.
Researchers at UNC have proposed a novel interpretation of an old biomarker which, if validated, could fundamentally transform the management of head and neck cancer.
Karyn Stitzenberg, MD, MPH, has been appointed to a four-year term on the North Carolina Advisory Committee on Cancer Coordination and Control.
When scientists and advocates join forces, good things can happen. Dr. Channing Der, Sarah Graham Kenan Professor of Pharmacology and UNC Lineberger faculty member, and Lori Matteson, a Raleigh pancreatic cancer survivor and advocate, joined over 600 other pancreatic cancer advocates and family members on a visit to Washington, DC.
Increased fatty acid synthesis is a metabolic signature of non-Hodgkin lymphoma
A diet based on American junk food could lead to more obesity-induced inflammation than a diet high in animal fat, according to a new study by researchers at the University of North Carolina at Chapel Hill.
Bruce Ham heard about the “Support Program for Single Fathers” from a friend. “I attended the first meeting. The guys in the group were going through exactly what I was going through and they were a similar age, they had all lost their wives to cancer, they all had kids in the house, so we had a lot in common. That’s what made it appealing to me.”
UNC Lineberger honored five clinical fellows for their research accomplishments and clinical excellence.
New JAMA study shows stepped-care intervention results in weight loss at lower cost, UNC's Deborah Tate co-author
A customized weight loss program may cost less to implement – despite having similar results – than a traditional weight loss program, according to a study published in the June 27 issue of The Journal of the American Medical Association (JAMA).
Parking difficulties inspired Barbara Riff to take motorcycle lessons with her son. Now she commutes to work via motorcycle and frequently takes motorcycle trips for fun.
CHAPEL HILL, NC – Sometimes, technology progresses faster than our ability to take advantage of it.
A new analysis done by University of North Carolina at Chapel Hill researchers has found that physical activity - either mild or intense and before or after menopause - may reduce breast cancer risk, but substantial weight gain may negate these benefits.
Todd Auman, PhD, has been appointed director of UNC Lineberger Comprehensive Cancer Center’s Tissue Procurement Facility.
What are cancer rumors and why do people share them?
Presents invited lecture at Harvard Medical School
Newly-Formed Collaboration to Focus on Vaccines and Inhaled Therapeutics
Genetic Marker in the Vitamin D Receptor Gene Associated With Increased Overall Survival for Pancreatic Cancer Patients
By Jeremy Moore
Following a blood stem cell transplant, survivors can face serious economic challenges that may negatively affect their quality of life.
Carey Anders, MD, and William Kim, MD, were awarded grants from the Damon Runyon Cancer Research Foundation.
Lisa Carey, MD, authored an editorial, titled “Neoadjuvant Trials of Human Epidermal Growth Factor Receptor 2 Targeting: How Many Drugs Do We Need?”
A gene known to be mutated in many different cancers, but thought to be relatively unimportant in melanoma, may be a key indicator of how the disease will respond to radiation therapy and whether it will spread.
Chapel Hill, NC – Debbie C. Dibbert, Director of External Affairs at UNC Lineberger Comprehensive Cancer Center, has been elected president of the National Association of Cancer Center Development Officers (NACCDO). She will serve a two-year term.
Votes, not baskets, will propel Cornucopia House to the Final Four in a national competition for a $25K mobile technology grant from AtlanticBT.
CHAPEL HILL, N.C. – A recent clinical trial testing a combination therapy for basal-like (also known as triple-negative) breast cancer demonstrates that a combination of two drugs with promising preclinical results is not as effective as researchers had hoped.
Chapel Hill, NC – Why do some cancers spread rapidly to other organs and others don’t metastasize? A team of UNC researchers led by Norman Sharpless, MD, have identified a key genetic switch that determines whether melanoma, a lethal skin cancer, spreads by metastasis.
WCHL named Jennifer Bowman a Hometown Hero for June 11, 2012. Each weekday the station selects a Hometown Hero who goes “over and above the call of duty,” exemplifying excellent service and dedication to others in the community.
Deborah Mayer, PhD, RN, AOCN, FAAN, associate professor in the UNC School of Nursing, has been appointed to a three-year term on the Cancer Survivorship Committee of the American Society of Clinical Oncology.
Kurt Ribisl, PhD, is co-author of the article “Internet Alcohol Sales to Minors” published online ahead of print in the May 2012 issue of the Archives of Pediatrics & Adolescent Medicine.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted in an article discussing the fetal genome and the possibility of clinic procedures being introduced in the next couple of years.
Victoria Bae-Jump, MD, PhD, has received a two-year $200,000 grant from the Department of Defense, to study “Preclinical and Clinical Investigations of the Impact of Obesity on Ovarian Cancer Pathogenesis.”
Congratulations to the N.C. Children’s Hospital for receiving top rankings in 10 out of 10 clinical categories in U.S. News & World Report’s 2012-13 “America’s Best Children’s Hospitals” list. The N.C. Children’s Hospital is ranked 26th in cancer.
UNC surgeon-scientist Dr. Nancy DeMore says, “As a physician, I’m acutely aware of how much more we need to learn about breast cancer and how urgently we need better therapies. It really gives me hope to be in the lab and to know that I’m working towards something that may make things better for patients.”
Chapel Hill - Patricia Cadle, MRE, BCC, Oncology Chaplain at UNC Health Care’s Department of Pastoral Care, was honored as the 2012 Chaplain of the Year by the North Carolina Chaplains’ Association. This award is presented annually at the Association’s spring conference in recognition of “distinguished ministry in pastoral care” to a chaplain “who serves patients, community and colleagues with grace and innovation.”