UNC Lineberger members and UNC School of Medicine researchers have found for the first time a biochemical mechanism that could be a cause of “chemo brain” – the neurological side effects such as memory loss, confusion, difficulty thinking, and trouble concentrating that many cancer patients experience while on chemotherapy to treat tumors in other parts of the body.
Former Postdoctoral fellow Aisa Sakaguchi, PhD (University of Gunma, Japan), graduate student Matt Simon (Ahmed lab), and Peter Sarkies, PhD are first authors for this study, which focuses on small RNA-mediated silencing & transgenerational fertility. UNC Lineberger member Shawn Ahmed, PhD and Eric Miska, PhD from the University of Cambridge are senior authors.
Matthew G. Ewend, MD, FACS, Van L. Weatherspoon, Jr. Eminent Distinguished Professor and Chair, UNC Department of Neurosurgery and UNC Lineberger member, has been awarded this year’s H. Fleming Fuller Award.
A team of researchers from UNC Lineberger and the University of California, Los Angeles published a paper in the current issue of Cancer, entitled “Provider-based research networks and diffusion of surgical technologies among patients with early-stage kidney cancer.” This study is the latest in a series from Lineberger researchers examining the impact of the National Cancer Institute’s Community Clinical Oncology Program (CCOP) as a potential facilitator for the dissemination of innovative cancer care practices into the broader community.
Dongmei Yang and Wuguo Chen in the Dittmer lab report X-chromosome targeted sequencing, which identified a mutation in IRAK1 kinase as a common driver of a viral lymphoma in the Nov 4 issue of the Proceedings of the National Academy of Sciences. This represent a novel target for directed therapy against this cancer
Angela Smith, MD MS and Matthew Milowsky, MD have published an editorial in the Journal of Clinical Oncology entitled “Is Extending surveillance guidelines for renal cell carcinoma without understanding patient outcomes putting the cart before the horse?” The editorial accompanies an article which evaluates the ability of current surveillance guidelines to capture RCC recurrences and assesses the duration of surveillance required to capture 90-100% of recurrences. Drs. Smith and Milowsky discuss whether modifying existing surveillance guidelines is warranted and highlight several considerations including the generalizability of results, current characterization of low- and high-risk RCC, and future role of genomics in improving risk stratification and design of surveillance guidelines.
Congratulations to nurse practitioner Mary Dunn and clinical nurse Lauren Terzo for winning the 2014 Oncology Nursing Excellence Award and to financial counselor Cynthia Moody and administrative support supervisor Christine Nadel, winners of the 2014 Clinical Services Excellence Award.
Over 100 people had the opportunity to learn about cancer, aging and resilience from UNC cancer care experts on Friday, November 14, at Cancer Care and Older Adults: A Public Forum hosted by UNC Lineberger Comprehensive Cancer Center.
UNC Lineberger researchers and colleagues at The University of Texas MD Anderson Cancer Center have developed a new approach to block the KRAS oncogene, one of the most frequently mutated genes in human cancer. The approach, led by Chad Pecot, MD, an assistant professor of medicine at UNC, offers another route to attack KRAS, which has proven to be an elusive and frustrating target for drug developers.
Stergios Moschos, MD, associate professor and UNC Lineberger Comprehensive Cancer Center member, is among 11 physicians from across the country to receive the National Cancer Institute (NCI) 2014 Cancer Clinical Investigator Team Leadership Award.
The proportion of adolescent girls receiving human papillomavirus (HPV) vaccines was much lower in states with higher rates of cervical cancer incidence and mortality, according to data presented by doctoral student Jennifer Moss at the American Association for Cancer Research (AACR) conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Nov. 9–12.
The 12th annual Avon Walk for Breast Cancer season concluded with the Charlotte Walk on October 26, raising $1.4 million to accelerate breast cancer research and improve access to screening, diagnosis, treatment and education. Hazel Nichols, PhD, assistant professor epidemiology at UNC Gillings School of Global Public Health is leading one of five teams in the Carolinas awarded a grant of $200,000 to support a study that will analyze data from 18 ongoing studies on pregnancy-associated breast cancer.
Dr. Liza Makowski, assistant professor in Nutrition, and postdoctoral fellow Dr. Sneha Sundaram published a manuscript entitled “Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice” in PLOS One. Coauthors include Dr. Alex Freemerman (Nutrition), Dr. Joe Galanko and Mr. Kirk McNaughton (MS) in Physiology, Ms. Kat Bendt (MS) and Mr. David Darr (MS) in UNC Lineberger’s Mouse Phase 1 Phenotyping Unit, and Dr. Melissa Troester (Epidemiology and Pathology and Laboratory Medicine).
Stephanie A. Montgomery, PhD, DVM, Dipl. ACVP, Assistant Professor in Pathology & Laboratory Medicine, is the new Faculty Director of UNC Lineberger's Animal Histopathology Core. Investigators utilizing animal models can now receive expert experimental pathology support from newly expanded services, including consultation on pathologic specimen collection and experimental design; training in macroscopic and microscopic examination of animals; establishment of histopathologic scoring schemes; evaluation of routine histochemical stains, immunohistochemical, and immunofluorescent tissue labeling; and publication quality image production of animal tissues.
The Secure Data Analysis Platform Development Team (SeDAP) - Ciearro Faulk, Stephen Galla and Adrian Meyer - have won an Information Techology Award from the University of North Carolina at Chapel Hill. The trio developed a computing environment combining high accessibility, high security, and high data throughput within a virtual desktop infrastructure (VDI). Its main objective is to enable collaboration for multi-disciplinary and multi-locational research teams while leveraging existing knowledge, resources, talents, and tools.
Chad Pecot, MD, assistant professor in hematology and oncology, has received a V Scholar Award from the The V Foundation for Cancer Research. Dr. Pecot is one of 20 recipients in the United States to receive the two-year $200,000 award.
Targeting CC-Chemokine Receptor 7 (CCR7) with fully human anti-CCR7 antibodies for the prevention of graft-versus-host disease.
The UNC Department of Urology is once again participating in Movember, a global mustache-growing fundraising campaign meant to spark conversation and raise funds for men’s health programs.
Over 5,000 cancer patients are now enrolled in the UNC Health Registry, an initiative funded by the University Cancer Research Fund established to better understand the long-term consequences of cancer, which affect many North Carolinians. This milestone hits the half-way mark of the 10,000 enrollment goal.