UNC Lineberger Comprehensive Cancer Center researchers have developed a new integrated approach to pinpoint the genetic “drivers” of cancer, uncovering eight genes that could be viable for targeted breast cancer therapy. The study, published online August 24 in Nature Genetics, was authored by Michael Gatza, PhD, lead author and post-doctoral research associate; Grace Silva, graduate student; Joel Parker, PhD, director of bioinformatics, UNC Lineberger; Cheng Fan, research associate; and senior author Chuck Perou, PhD, professor of genetics and pathology.
Part of More Than $24.7 Million Awarded in New Grants by the St. Baldrick’s Foundation
An international scientific collaboration led by researchers at UNC has revealed new insights into the unique genetic alterations that contribute to a rare form of kidney cancer.
Angiogenesis inhibitors are a class of drugs commonly used in cancer therapy. However, there isn’t a way to identify patients who will benefit the most from treatment with these drugs. A new $275,000 grant could help Federico Innocenti, MD, PhD, and his team identify such patients based on their genetic profile.
Margaret L. Gulley, MD, served as a coauthor on The Cancer Genome Atlas publication of “The Comprehensive Molecular Characterization of Gastric Adenocarcinoma” in the journal Nature. The paper identifies four subtypes of the cancer, which could provides information to allow for better patient tumor type identification and the development of targeted therapies for the cancer.
Stephanie Wheeler, PhD, and Michael Pignone, MD, MPH, published “Regional variation in colorectal cancer testing and geographic availability of care in a publicly insured population” in the journal Health and Place. The paper found that less than 50 percent of eligible individuals had evidence of colorectal (CRC) testing.
Hyman Muss, MD, and Grant Williams, MD, published “Feasibility of geriatric assessment in community oncology clinics” in the Journal of Geriatric Oncology. The paper showed that performing a geriatric assessment in a community oncology clinic can be done in a similar timeframe as in an academic setting.
UNC Lineberger members David Margolis, MD, and Ronald Swanstrom, PhDm were both recently published in the journal Science.
A substantial number of older patients with limited life expectancy receive routine screenings for prostate, breast, cervical and colorectal cancer even though the procedures are unlikely to benefit them, according to research conducted at the University of North Carolina at Chapel Hill.
UNC Lineberger Comprehensive Cancer Center has awarded nine researchers with Developmental Research Awards to support their work in advancing the fields of clinical/translational and population science cancer research.
A recent article published in the July/August 2014 issue of Health Leaders magazine focuses on some of UNC Lineberger’s strengths that rank it among the nation’s leading cancer centers.
A recent U.S. News & World Report article highlights the nation’s cancer centers, focusing especially on those that the National Cancer Institute has designated as comprehensive cancer centers, citing advantages of patients being seen at or referred to these sites, including advances in technology and collaboration.
Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work, led by researchers at the UNC Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill and other TCGA sites, not only revamps traditional ideas of how cancers are diagnosed and treated, but could also have a profound impact on the future landscape of drug development.
Jean B. Sellers, RN, MSN has co-authored a chapter in the newly published book, Oncology Nurse Navigation: Delivering Patient-Centered Care Across the Continuum.
Nicole Baker, graduate student in the Department of Pharmacology, and member of Channing Der's lab, is the recipient of an a National Institutes of Health National Research Service Award Pre-Doctoral Fellowship.
Faculty members at the University of North Carolina School of Dentistry, The Scripps Research Institute (TSRI) and other institutions have discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that target the cancer’s underlying genetic causes.
Feng Liu, PhD, a research professor in the Division of Molecular Pharmaceutics and UNC Lineberger member, died tragically Thursday, July 24, after being assaulted and robbed while walking in a neighborhood near campus. Liu was a dedicated colleague, educator and researcher focused on gene and drug delivery.
Hepatitis C virus (HCV) lingers in the human body for years, slowly damaging the liver and leading to liver diseases such as hepatitis, cirrhosis and liver cancer, which is often fatal. Research conducted at the University of North Carolina at Chapel Hill has discovered a mechanism that facilitates the virus achieving this life-long persistence. Chronic HCV infection is the leading cause of liver cancer in the United States.
UNC Hospitals is nationally ranked in cancer, taking the number 38th spot in the country. The latest ranking is up from 43rd in 2013.
Dr. Antonio (Tony) Amelio recently began his joint appointment as assistant professor in the Department of Dental Ecology at the UNC School of Dentistry and as associate member at UNC Lineberger.