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UNC researchers discover how Hepatitis C virus persists for years

UNC researchers discover how Hepatitis C virus persists for years

Hepatitis C virus (HCV) lingers in the human body for years, slowly damaging the liver and leading to liver diseases such as hepatitis, cirrhosis and liver cancer, which is often fatal. Research conducted at the University of North Carolina at Chapel Hill has discovered a mechanism that facilitates the virus achieving this life-long persistence. Chronic HCV infection is the leading cause of liver cancer in the United States.

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UNC jumps 5 slots in 2014–15 U.S. News & World Report cancer rankings

UNC jumps 5 slots in 2014–15 U.S. News & World Report cancer rankings

UNC Hospitals is nationally ranked in cancer, taking the number 38th spot in the country. The latest ranking is up from 43rd in 2013.

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Amelio joins UNC School of Dentistry, UNC Lineberger

Amelio joins UNC School of Dentistry, UNC Lineberger

Dr. Antonio (Tony) Amelio recently began his joint appointment as assistant professor in the Department of Dental Ecology at the UNC School of Dentistry and as associate member at UNC Lineberger.

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Wong appointed to NCI Gastrointestinal Steering Committee

Wong appointed to NCI Gastrointestinal Steering Committee

Terence Wong, MD, PhD, Director of Molecular Imaging and Medical Director of the Biomedical Research Imaging Center (BRIC), will serve as a representative on the National Cancer Institute’s Gastrointestinal Steering Committee, formed to improve clinical trials in gastrointestinal cancer clinical research. Dr. Wong will represent the ECOG-ACRIN Cancer Research Group, a clinical trial cooperative group.

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Kaufmann article chosen as Environmental and Molecular Mutagenesis Editor’s Choice

Kaufmann article chosen as Environmental and Molecular Mutagenesis Editor’s Choice

William K. Kaufmann, PhD, article on chromosomal mutations in melanoma has been chosen as the featured Editor’s Choice article in the journal Environmental and Molecular Mutagenesis. The paper, which will be featured on the issue’s cover, was chosen because of the potential of the research to lead to new treatment approaches for melanoma.

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TCGA announces molecular profile of lung adenocarcinoma

TCGA announces molecular profile of lung adenocarcinoma

The Cancer Genome Atlas has published a comprehensive genomic profile of the cancer lung adenocarcinoma, one of the leading causes of death worldwide, in the journal Nature. Members contributing to the paper include Neil Hayes, Matthew Wilkerson, Katherine Hoadley, Charles Perou, Joel Parker, Mei Huang, Kimryn Rathmell and others.

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Muss leads Grand Rounds for JCO

Muss leads Grand Rounds for JCO

Hyman Muss, MD, director of the Geriatric Oncology Program at UNC Lineberger, published a Grand Rounds article on adjuvant chemotherapy for older women with breast cancer in the Journal of Clinical Oncology.

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Webster-Cyriaque named to Cancer Etiology Study Section

Webster-Cyriaque named to Cancer Etiology Study Section

Jennifer Webster-Cyriaque, DDS, PhD, will serve as a member of the National Institutes of Health’s Cancer Etiology Study Section, Center for Scientific Review. Members are selected on the basis of their demonstrated competence and achievement in their scientific discipline as evidenced by the quality of research accomplishments, publications in scientific journals, and other significant scientific activities, achievements and honors. The appointment will last until 2020.

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Campbell awarded 2014 Battle Cancer Research Award

Campbell awarded 2014 Battle Cancer Research Award

Sharon Campbell, professor of biochemistry and biophysics, has been awarded the 2014 Hyman L. Battle Distinguished Cancer Research Award by the UNC School of Medicine. The award recognizes sustained, exceptional cancer research over a career by School of Medicine faculty.

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Reeder-Hayes and Carey publish JCO editorial

Katie Reeder-Hayes, MD, and Lisa A. Carey, MD, have published an editorial in the Journal of Clinical Oncology titled "How Low Should We Go? The Search for Balance in Management of Small Human Epidermal Growth Factor Receptor 2–Positive Breast Cancers." The editorial accompanies an article analyzing the outcomes among women with small, node-negative, HER2-positive tumors.

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Kim receives 2014 Bladder Cancer Research Innovation Award

Kim receives 2014 Bladder Cancer Research Innovation Award

The Bladder Cancer Advocacy Network (BCAN) has awarded William Kim, MD, associate professor of medicine, urology, and genetics, University of North Carolina at Chapel Hill and UNC Lineberger Comprehensive Cancer Center, with the 2014 Bladder Cancer Research Innovation Award to support his project “Immune Characterization of High-Grade Bladder Cancer.”

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UNC Lineberger researchers recognized by Thomson-Reuters as highly influential

UNC Lineberger researchers recognized by Thomson-Reuters as highly influential

Six UNC Lineberger members are among the most often-cited scientists in the world, according to the Thomson Reuters 2014 Highly Cited Researchers list.

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N.C. Medical Journal July/August issue highlights UNC Lineberger cancer research

N.C. Medical Journal July/August issue highlights UNC Lineberger cancer research

Cancer care in North Carolina is the focus of the July/August issue of the North Carolina Medical Journal (NCMJ). The issue, co-guest-edited by UNC Lineberger Comprehensive Cancer Center members Ethan Basch, MD, and Stephanie Wheeler, PhD, MPH, features articles on a wide variety of issues that determine how the state’s residents receive treatment for cancer.

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Study in mice finds weight loss reduces progression of basal-like breast cancer

Obesity, epidemic in the U.S. and worldwide, is one of the important modifiable risk factors for breast cancer, especially a particularly aggressive subtype called basal-like breast cancer (BBC). Population studies have suggested that lifestyle interventions, including weight loss, could prevent a large proportion of this type of cancer; however, data on the effect of weight loss on BBC risk are limited and the mechanisms involved uncertain.

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Doctors not adequately informing patients of cancer screening pros and cons, study finds

Though cancer screening has come a long way, physicians still do not thoroughly discuss with patients the advantages and disadvantages of these procedures before decisions are made to undergo the screenings, according to a new study co-authored by a physician from The University of North Carolina at Chapel Hill’s Gillings School of Global Public Health.

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UNC-developed tools improve accuracy of cancer DNA sequencing

UNC-developed tools improve accuracy of cancer DNA sequencing

The ability of researchers and physicians to use DNA sequencing to pinpoint the genetic mutations that cause cancer has led to greater understanding of the causes of the disease and development of drugs that treat tumors by targeting specific mutations. A pair of papers published by researchers at the UNC Lineberger Comprehensive Cancer Center reveal new tools that can improve the accuracy of tumor sequencing.

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UNC-developed tools improve accuracy of cancer DNA sequencing

The ability of researchers and physicians to use DNA sequencing to pinpoint the genetic mutations that cause cancer has led to greater understanding of the causes of the disease and development of drugs that treat tumors by targeting specific mutations. A pair of papers published by researchers at the UNC Lineberger Comprehensive Cancer Center reveal new tools that can improve the accuracy of tumor sequencing.

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Chen chosen for ASCO Leadership Development Program

The American Society of Clinical Oncology (ASCO) has chosen Ronald Chen, MD, MPH, assistant professor of radiation oncology and member of the UNC Lineberger Comprehensive Cancer Center, as a member of the 2014-2015 ASCO Leadership Development Program.

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WRAL story highlights bladder cancer vaccine study at UNC

A story that ran on Raleigh-based CBS affiliate WRAL focuses on a new bladder cancer vaccine being studied at UNC, called Impact Therapy. The vaccine works to target cancer cells with minimal side effects.

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Shared decision making still lacking for cancer screening

NEW YORK (Reuters Health) - When it comes to cancer screening, doctors often do not adequately discuss the balance of pros and cons with their patients, a new study suggests.

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