UNC Lineberger Comprehensive Cancer Center researchers and UNC colleagues will present the latest findings from studies and lead educational sessions at the 64th American Society of Hematology (ASH) Annual Meeting in New Orleans, Dec. 10-13.
ASH is the world’s largest professional society of hematologists dedicated to furthering the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, including cancer. This year’s meeting is expected to attract more than 25,000 hematology professionals, including clinicians, researchers, medical students and patient advocates.
UNC Lineberger and UNC researchers presenting at the meeting include:
Friday, Dec. 9
1:30-2 p.m. CT | 2:40-3:10 p.m. CT | 4:35-5 p.m. CT | River City Ballroom (Mardi Gras World)
Blood Buddies: Adult Clinical Classical Hematology
Presenter: Alice Ma, MD
Symposium
2:50-3:50 p.m. CT | 295-296
Scientific Workshop on Interplay between Coagulation and Malignancy Program: Scientific Workshops
Moderator: Nigel Mackman, PhD
Saturday, Dec. 10
Career Development Lunch
11:15 a.m.-12:15 p.m. CT | St. Charles Ballroom (Hilton New Orleans Riverside)
Adult Clinical Classical Hematology
Presenter: Stephan Moll, MD
Oral Presentation
12-1:30 p.m. CT | 243-245
12:45 p.m. CT
Gabriell Erisnor, BS, Jiona Mills, BSPH, Paul Mihas, MA, Lauren Bates, MA, Mykela Moore, BA, Tanya M. Wildes, MD, Leah Adams, BS, Hyman B Muss, MD, and Shakira J. Grant, MBBS
Presenter: Shakira J. Grant, MBBS
2-3:30 p.m. CT | 391-392
3:15 p.m. CT
270 Associations of Minor Histocompatibility Antigens with Clinical Outcomes Following Allogeneic Hematopoietic Cell Transplantation
Othmane Jadi, BA, BS, Hancong Tang, PhD, Kelly Shea Olsen, MSc, Steven Vensko, PhD, Qianqian Zhu, PhD5, Yiwen Wang, Christopher A. Haiman, Loreall Pooler, Xin Sheng, MS, Guy Brock, PhD, Amy Webb, PhD, Marcelo C Pasquini, MD, MS, Philip L. McCarthy, MD, Stephen R. Spellman, Theresa E. Hahn, PhD, Benjamin G. Vincent, MD, Paul M. Armistead, MD, PhD, and Lara E. Sucheston-Campbell, PhD, MS
Presenter: Othmane Jadi, BA, BS
4-5:30 p.m. CT | 208-210
4:15 p.m.
380 “If You Don’t Trust Your Doctor That Much…You’d Feel Less Confident Doing a Research Study”: Factors Influencing Black Patient Participation in Hematology Trials
Shakira J. Grant, MBBS, Milenka Jean-Baptiste, MPH, Mykela Moore, BA, Jiona Mills, BSPH, Lauren Bates, MA, Sascha A. Tuchman, MD, MHS, and Paul Mihas, MA
Presenter: Shakira J. Grant, MBBS
5 p.m.
383 “You Have Your Knowledge, but I Have My Knowledge of My Body”: The Hematologist-Patient Relationship and Enrollment of Black Participants in Clinical Trials
Shakira J. Grant, MBBS, Milenka Jean-Baptiste, MPH, Mykela Moore, BA, Jiona Mills, BSPH, Lauren Bates, MA, Sascha A. Tuchman, MD, MHS, and Paul Mihas, MA
Presenter: Shakira J. Grant, MBBS
Poster Presentation
5:30-7:30 p.m. CT | Hall D
1046 Protease Activated Receptor-1 (PAR-1) Inhibition By Parmodulin 2, but Not Vorapaxar, Protects Sickle Cell Mice from Heme-Induced Acute Chest Syndrome
Kailyn Lowder, Nirupama Ramadas, PhD, Rafal Pawlinski, PhD, and Erica Sparkenbaugh, PhD
Presenter: Kailyn Lowder
1061 Balanced Crystalloids Versus Normal Saline in Noncritically Ill Adults with Sickle Cell Disease Admitted from the Emergency Department: A Sub-Analysis of the Salt-ED Trial
Marcus A. Carden, MD, Jeffrey D. Lebensburger, DO, Vimal K Derebail, MD, and Wesley H. Self, MD, MPH
Presenter: Marcus A. Carden, MD
1062 Evaluating Equations for Estimated Glomerular Filtration Rate (eGFR) in Patients with Sickle Cell Disease (SCD)
Vimal K Derebail, MD, MPH, Laura Y Zhou, MS, Laila Elsherif, PhD, Kammie L Patillo, RN, David Wichlan, Kristina Landes, MPH, Paula McCune, RN, Laura R Loehr, MD, PhD, MS, Robert M Cronin, MD, MS, Payal C Desai, MD, Jianwen Cai, PhD, and Kenneth I Ataga, MD
Presenter: Vimal K Derebail, MD, MPH
Antonia V. Bennett, PhD, Xianming Tan, PhD, Matthew C. Foster, MD, Daniel R. Richardson, MD, MSc, MA, Ashley L. Bryant, PhD, RN, OCN, FAAN, William A. Wood, MD, MPH, Ashley O. Yocum, PhD, Alice S. Mims, MD, Uma Borate, MD, and Amy Burd, PhD
Presenter: Antonia V. Bennett, PhD
Sonia J. Laurie, PhD, Joseph P. Foster II, BS, Danny W. Bruce, PhD, Hemamalini Bommiasamy, PhD, Samantha G. Pattenden, PhD, Ian J. Davis, MD, PhD, and Jonathan S. Serody, MD
Presenter: Sonia J. Laurie, PhD
1948 Shared Graft Versus Leukemia Minor Histocompatibility Antigens in DISCOVeRY-BMT
Kelly Shea Olsen, MSc, Othmane Jadi, BA, BS, Sarah Dexheimer, MSc, Dante Bortone, PhD, Steven Vensko, PhD, Hancong Tang, PhD, Marisa Diiorio, BA, Tanvi Saran, BS, David Dingfelder, Sarah Bennett, BS, Qianqian Zhu, PhD, Yiwen Wang, Christopher A. Haiman, Loreall Pooler, Xin Sheng, MS, Amy Webb, PhD, Marcelo C Pasquini, MD, MS, Philip L. McCarthy, MD, Stephen R. Spellman, Eric T. Weimer, PhD, Theresa E. Hahn, PhD, Lara E. Sucheston-Campbell, PhD, Paul M. Armistead, MD, PhD, and Benjamin G. Vincent, MD (Drs. Armistead and Vincent are co-last authors)
Presenter: Kelly Shea Olsen, MSc
1975 Characterization of a Cyclic Dinucleotide Metabolic Switch to Fuel Antitumor Immunity
Jeremy A. Meier, MD, PhD, Katie E. Hurst, MPH, David L. Corcoran, Jessica E. Thaxton, PhD, and Jonathan S. Serody, MD
Presenter: Jeremy A. Meier, MD, PhD
2287 Functional Status and Mortality Among Older Adults with Multiple Myeloma
Christopher E. Jensen, MD, Tzy-Mey Kuo, PhD, MPH, Matthew Leblanc, PhD, BSN, RN, Chris D Baggett, PhD, Xi Zhou, Katherine E Reeder-Hayes, and Jennifer L Lund, PhD
Presenter: Christopher E. Jensen, MD
Sunday, Dec. 11
How I Treat: Bringing Science to Clinical Dilemmas
8-9 a.m. | Marlborough A (Hilton New Orleans Riverside)
Thrombosis and Anticoagulation – Duration of Therapy, Thrombophilia
Presenter: Stephan Moll, MD
Plenary Scientific Session
2-4 p.m. CT | Hall E
Steven P Grover, PhD, Tomohiro Kawano, MD, PhD, Linda Sundler Bjorkman, MD, Francesco P Giorgino, BSc, Sophia Dhrolia, Rohan Kasthuri, Sigrid Braekkan, PhD, Zsofia Polai, Henriette Farkas, MD, PhD, Arne Egesten, MD, PhD, John-Bjarne Hansen and Nigel Mackman, PhD
Presenter: Steven P. Grover, PhD
Symposium
4:30-6 p.m. CT | 288-290
Moderator: Alice Ma, MD
Poster Presentation
6-8 p.m. CT | Hall D
2364 Parmodulin, an Allosteric Inhibitor of Protease Activated Receptor 1 (PAR1) Protects Sickle Cell Mice from Thromboinflammation and Endothelial Dysfunction
Nirupama Ramadas, PhD, Kailyn Lowder, Laurent O. Mosnier, PhD, Rafal Pawlinski, PhD, and Erica Sparkenbaugh, PhD
Presenter: Nirupama Ramadas, PhD
2437 Decreased Platelet Reactivity and Function in a Mouse Model of Pancreatic Cancer
Tomohiro Kawano, MD, PhD, Yohei Hisada, PhD, Steven P Grover, PhD, Wyatt Schug, David Paul, Wolfgang Bergmeier, and Nigel Mackman, PhD
Presenter: Tomohiro Kawano, MD, PhD
2442 Accelerated Platelet Clearance in Mice with Constitutive Store-Operated Calcium Entry Is Independent of Caldag-GEFI/Rap1 Activation
Robert H Lee, PhD, Bernhard Nieswandt, PhD, and Wolfgang Bergmeier
Presenter: Robert H. Lee, PhD
Christopher Dittus, DO, MPH, Roy Ervin Strowd III, MD, MEd, MS, Kelly Hoye, MS, CCRP, Xianming Tan, PhD, Jordan Miller, PharmD, Celeste Bello, MD, Amir Khandani, MD, and Anne W. Beaven, MD
Presenter: Christopher Dittus, DO, MPH
Marriam Mponda, MBBS, Evaristar Kudowa, MPH, Bongani Kaimila, MBBS, Edwards Kasonkanji, MPH, Noel Mumba, Dip Clin Med, Lusayo Simwinga, MBBS, Tamiwe Tomoka, MBBS, Yuri Fedoriw, MD, and Matthew Painschab, MD
Presenter: Marriam Mponda, MBBS
3285 Development of a mRNA Lipid Nanoparticle (mRNA-LNP) Cancer Vaccine to Prevent Leukemia Relapse after Stem Cell Transplant
Anson Snow, MD, Lin Lin, PhD, Sally A. Hunsucker, PhD, Ying Wang, PhD, Rihe Liu, PhD, and Paul M. Armistead, MD, PhD
Presenter: Anson Snow, MD
Cassiopeia Frank, PA-C, Nigel S. Key, Micah J. Mooberry, MD, Raj S. Kasthuri, MD, and Stephan Moll, MD
Presenter: Cassiopeia Frank, PA-C
3552 Strategies for Implementing an Oral Medication Adherence Intervention in Academic and Community Cancer Settings
James B. Collins IV, PharmD, Michele A. Muir, PharmD, Emily Mackler, PharmD, Ashley L. Bryant, PhD, RN, OCN, FAAN, William A. Wood, MD, MPH, Stephanie Wheeler, PhD, MPH, Leah Zullig, PhD, MPH, Jennifer E. Lafata, PhD, and Benyam Muluneh, PharmD
Presenter: James B. Collins IV, PharmD
Monday, Dec. 12
Spotlight Session
2:45-4 p.m. | 288-290
Presenter: Stephan Moll, MD
Oral Presentation
3 p.m. CT | 220-222
800 ETO2 Recruitment of NuRD to the γ-Globin Locus Involves Multivalent Interaction with GATAD2A
David C. Williams, MD, PhD, Gage Oliver Leighton, Parnika Agrawal, Glory Dan-Dukor, Shengzhe Shang, and Gordon Ginder, MD
Presenter: David C. Williams, MD, PhD
Special-Interest Sessions
4:30-6 p.m. CT | 217-219
Chair: William A. Wood, MD, MPH
Moderator: Samuel Rubinstein, MD
Poster Presentation
6-8 p.m. CT | Hall D
3701 The Prevalence and Impact of Low Oxygen in People with Sickle Cell Anemia: A Pilot Study
Ada Chang, BSc, Sherri Morris, MSN, AGPCNP-BS, Barbara L LeVarge, MD, Samuel R Wilson, MD, MSCR, and Jane Alison Little, MD
Presenter: Ada Chang, BSc
3754 Thrombocytopenia in a Mouse Model of Pancreatic Cancer
Michelle M. Luo, Yaqiu Sang, PhD, Maria N. Barrachina, PhD, Andrew P. Stone, PhD, Keely G. Davey, PhD, Yi Yang, PhD, Lori A. Holle, PhD, Tomohiro Kawano, MD, PhD, Nigel Mackman, PhD, Matthew J. Flick, PhD, Kellie R. Machlus, PhD, and Alisa S. Wolberg, PhD
Presenter: Michelle M. Luo
Robert H Lee, PhD, Tanvi Rudran, Silvio Antoniak, Alisa S. Wolberg, PhD, and Wolfgang Bergmeier
Presenter: Robert H. Lee, PhD
Michael Stobb, Dougald Monroe, PhD, Keith B. Neeves, PhD, Suzanne Sindi, Aaron Fogelson, and Karin Leiderman, PhD
Presenter: Karin Leiderman, PhD
Joshua F. Zeidner, MD, Matthew C. Foster, MD, Mary Johnson, Ying Huang, MS, MA, Ronan T. Swords, MD, Eytan Stein, MD, James M. Foran, MD, Maria R. Baer, MD, Wendy Stock, MD, Yazan F. Madanat, MD, Tibor Kovacsovics, MD, Rebecca L. Olin, MD, William G. Blum, MD, Gary J. Schiller, MD, Tara L. Lin, MD, Robert L. Redner, MD, Zeina Al-Mansour, MD, Emily K Curran, MD, Nyla A. Heerema, PhD, Molly Martycz, Leonard Rosenberg, PhD RPh, Sonja Marcus, MPH, Ashley O. Yocum, PhD, Timothy Chen, PhD, Mona Stefanos, Franchesca Druggan, MSc, Amy Burd, PhD, Ross L. Levine, MD, Brian J. Druker, Uma Borate, MD, John C. Byrd, MD, and Alice S. Mims, MD
Presenter: Joshua F. Zeidner, MD
4086 Changes in Symptoms, Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia Treated with Venetoclax and Hypomethylating Agents
Ya-Ning Chan, PhD, RN, Daniel R. Richardson, MD, MSc, MA, Courtney Berry, BS, MA, BSN, RN, OCN, Stephanie Betancur, BSN, RN, Hayden Michael Dumaw, BS, Todd Schwartz, DrPH, Mackenzi Pergolotti, PhD, OTR/L, Susan Coppola, MS, OT/L, OTD, FAOTA, Christopher Jensen, MD, Matthew C. Foster, MD, and Ashley L. Bryant, PhD, RN, OCN, FAAN
Presenter: Ashley L. Bryant, PhD, RN, OCN, FAAN
4582 Amphiregulin Derived from Multiple Sources Is Important for Barrier Function of the Intestine Following Hematopoietic Stem Cell Transplantation
Danny W. Bruce, PhD, Oleg Kolupaev, PhD, Sonia J. Laurie, PhD, Hemamalini Bommiasamy, PhD, and Jonathan S. Serody, MD
Presenter: Danny W. Bruce, PhD
4594 Cytotoxic Therapy Impairs the Stromal Niche Supporting ILC Development in the Bone Marrow
Oleg Kolupaev, PhD, Danny W. Bruce, PhD, Sonia J. Laurie, PhD, Hemamalini Bommiasamy, PhD, and Jonathan S. Serody, MD
Presenter: Oleg Kolupaev, PhD