A comprehensive genetic analysis of invasive bladder cancer tumors has found that the disease shares genetic similarities with two forms of breast cancer, according to researchers at the University of North Carolina Lineberger Cancer Center. Bladder cancer, which is the fourth most common malignancy in men and ninth most common in women in the United States, claimed more than 15,000 patients last year.
“This is an important finding because of the field’s increased interest in ‘metabolic reprogramming’ of immune cells. Understanding how macrophage substrate metabolism impacts inflammation is crucial to our being able to develop novel therapies for obesity and diabetes, and even cancer," said study author Liza Makowski, PhD, assistant professor of nutrition at the Gillings School and member of the UNC Lineberger Comprehensive Cancer Center.
UNC Lineberger receives jointly awarded $1 million research grant to investigate novel target in melanoma
The $1 million award from the Melanoma Research Alliance and the Saban Family Foundation will support research to improve the treatment of melanoma, the most aggressive type of skin cancer.
A team led by Cyrus Vaziri, PhD, and William Janzen at the University of North Carolina at Chapel Hill has received a grant from the National Institutes of Health for research that could help make chemotherapy drugs more effective.
The response of a patient with metastatic brain tumors to treatment with stereotactic radiosurgery in the first six-to-twelve weeks can indicate whether follow-up treatments and monitoring are necessary, according to research conducted at the University of North Carolina.
The UNC Lineberger Comprehensive Cancer Center announces The Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences. This cash award goes directly to the recipient and can be used for any purpose.
The journal highlights research performed by UNC Lineberger member Angela Smith, MD, that links a loss of muscle mass, known as sarcopenia, in women to complications from a cystectomy. Women who experienced sarcopenia were found to have a 43 percent chance of major complications compared to 10 percent for women who did not experience muscle loss.
While ultrasound provides a less expensive and radiation-free alternative to detecting and monitoring cancer compared to technologies such as X-rays, CT scans and MRIs, the lower clarity and resolution of ultrasound has limited its use in cancer treatment. Researchers at the University of North Carolina at Chapel Hill have overcome this limitation by combining ultrasound with a contrast agent comprised of micro-sized bubbles that pair with an antibody produced at elevated levels by many cancers.
Qi Zhang sees himself as a warrior. In his lab at the University of North Carolina at Chapel Hill, he wages war on genetic diseases such as cancer and heart disease on a battlefield measured with single atoms.
The Oncology Nursing Society Foundation selected MSN student Sean Gallagher, RN, for a 2013 APN/DNP Student Fellowship. Mr. Gallagher's fellowship will cover the costs of his research project "Survivors of HPV-Related Oropharyngeal Cancer--Knowledge of Human Papillomavirus (HPV) and Impact of HPV on Sexual Intimacy."