The Leukemia & Lymphoma Society (LLS) held their Light The Night Walk at Rock Quarry Park in Durham on Saturday, September 20. The evening fundraising walk celebrated and commemorated lives touched by blood cancer. More than a walk, the evening had a carnival atmosphere and included refreshments, entertainment, music and kids' activities
The Metastatic Breast Cancer Network (MBCN) held its 8th Annual National Conference in Chapel Hill September 19-21, 2014 in conjunction with the UNC Lineberger Comprehensive Cancer Center.
Matthew Nielsen, MD, MS, assistant professor of urology and adjunct assistant professor of epidemiology and health policy & management, has been named director of urologic oncology in the UNC Department of Urology. In his new role, he joins Matthew Milowsky, MD, associate professor of medicine, as co-director of the Multidisciplinary Genitourinary Oncology Service at the N.C. Cancer Hospital.
On September 24, 2014, UNC Lineberger held a reception to honor Dr. Sharon Campbell, recipient of the 2014 Hyman L. Battle Distinguished Cancer Research Award.
With his selection to the NIH Council of Councils, Terry Magnuson, PhD, becomes the first UNC scientist appointed to the board dedicated to funding the biggest ideas in medical research.
Sixteen years after scientists found the genes that control the circadian clock in all cells, the lab of UNC’s Aziz Sancar, MD, PhD, discovered the mechanisms responsible for keeping the clock in sync.
Blossom Damania, PhD, professor of microbiology and immunology, has been named Assistant Dean for Research at the UNC School of Medicine, effective immediately.
New clinical guidelines have been announced for the treatment of men with metastatic castration-resistant prostate cancer (CRPC) by the American Society of Clinical Oncology (ASCO) and Cancer Care Ontario (CCO). Ethan Basch, MD, director of the Cancer Outcomes Research Program at UNC Lineberger Comprehensive Cancer Center, served as the co-chair of the ASCO/CCO expert panel that developed the guideline.
Upstream of the proteins that cancer cells use to proliferate sits RBM4, a gene-splicing protein that UNC researcher Zefeng Wang, PhD, discovered is drastically reduced in human lung and breast cancer cells.
Research led by UNC’s Kathleen Caron, PhD, shows that halting the protein CXCR7 leads to over activation of adrenomedullin, a hormone needed at proper levels for normal cardiovascular development
Thanks to you, 2013-14 was a big year for UNC Lineberger.
UNC Lineberger secures three major NCI grants to advance the nation’s clinical trials program.
Carey Anders, MD, UNC Lineberger member and associate professor, was a presenter and moderator at The 13th Annual Round Asia Oncology Forum (RAOF) in Hong Kong on August 29 - 30, 2014. The theme of this year’s forum was “Expanding our armory in personalized cancer treatment.”
The UNC Eshelman School of Pharmacy has received a $3 million gift from philanthropist and pharmaceutical-industry executive Fred Eshelman. Eshelman’s gift will support the work of the School’s Center for Integrative Chemical Biology and Drug Discovery, led by UNC Lineberger member Stephen Frye, PhD. The center is dedicated to evaluating and developing potential drug targets discovered by UNC faculty.
Six researchers have been awarded 2014 University Cancer Research Fund (UCRF) Innovation Awards for promoting innovative and new ideas in cancer research at the University of North Carolina at Chapel Hill.
UNC Health Care and Rex Healthcare co-sponsored “Field of Hope” at the Durham Bulls game on Saturday, August 23 with a portion of special ticket sales going to the Kay Yow Cancer Fund.
The Lung Cancer Initiative of NC hosted a statewide Lung Cancer Summit on August 23 at the N.C. Cancer Hospital. Lung cancer advocates were bolstered with training, resources, knowledge and the courage to take action. UNC Lineberger Comprehensive Cancer Center was the Host Sponsor of the event.
For more than 20 years, Sharon Campbell, PhD, has been studying Ras, a protein implicated in 30 percent of all cancers. Now she’s on the hunt for alternative ways to shut the protein down.
Kirsten Bryant, PhD, was recently recognized by the Pancreatic Cancer Action Network for her dual role in the fight against pancreatic cancer.
UNC Lineberger Comprehensive Cancer Center researchers have developed a new integrated approach to pinpoint the genetic “drivers” of cancer, uncovering eight genes that could be viable for targeted breast cancer therapy. The study, published online August 24 in Nature Genetics, was authored by Michael Gatza, PhD, lead author and post-doctoral research associate; Grace Silva, graduate student; Joel Parker, PhD, director of bioinformatics, UNC Lineberger; Cheng Fan, research associate; and senior author Chuck Perou, PhD, professor of genetics and pathology.
Part of More Than $24.7 Million Awarded in New Grants by the St. Baldrick’s Foundation
An international scientific collaboration led by researchers at UNC has revealed new insights into the unique genetic alterations that contribute to a rare form of kidney cancer.
A substantial number of older patients with limited life expectancy receive routine screenings for prostate, breast, cervical and colorectal cancer even though the procedures are unlikely to benefit them, according to research conducted at the University of North Carolina at Chapel Hill.
UNC Lineberger Comprehensive Cancer Center has awarded nine researchers with Developmental Research Awards to support their work in advancing the fields of clinical/translational and population science cancer research.
A recent article published in the July/August 2014 issue of Health Leaders magazine focuses on some of UNC Lineberger’s strengths that rank it among the nation’s leading cancer centers.
A recent U.S. News & World Report article highlights the nation’s cancer centers, focusing especially on those that the National Cancer Institute has designated as comprehensive cancer centers, citing advantages of patients being seen at or referred to these sites, including advances in technology and collaboration.
Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work, led by researchers at the UNC Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill and other TCGA sites, not only revamps traditional ideas of how cancers are diagnosed and treated, but could also have a profound impact on the future landscape of drug development.
Faculty members at the University of North Carolina School of Dentistry, The Scripps Research Institute (TSRI) and other institutions have discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that target the cancer’s underlying genetic causes.
Feng Liu, PhD, a research professor in the Division of Molecular Pharmaceutics and UNC Lineberger member, died tragically Thursday, July 24, after being assaulted and robbed while walking in a neighborhood near campus. Liu was a dedicated colleague, educator and researcher focused on gene and drug delivery.
Hepatitis C virus (HCV) lingers in the human body for years, slowly damaging the liver and leading to liver diseases such as hepatitis, cirrhosis and liver cancer, which is often fatal. Research conducted at the University of North Carolina at Chapel Hill has discovered a mechanism that facilitates the virus achieving this life-long persistence. Chronic HCV infection is the leading cause of liver cancer in the United States.
UNC Hospitals is nationally ranked in cancer, taking the number 38th spot in the country. The latest ranking is up from 43rd in 2013.
Dr. Antonio (Tony) Amelio recently began his joint appointment as assistant professor in the Department of Dental Ecology at the UNC School of Dentistry and as associate member at UNC Lineberger.
Sharon Campbell, professor of biochemistry and biophysics, has been awarded the 2014 Hyman L. Battle Distinguished Cancer Research Award by the UNC School of Medicine. The award recognizes sustained, exceptional cancer research over a career by School of Medicine faculty.
Three physician-scientists from the UNC Lineberger Comprehensive Cancer Center have been chosen as the 2014 John William Pope Clinical Fellows.
The Bladder Cancer Advocacy Network (BCAN) has awarded William Kim, MD, associate professor of medicine, urology, and genetics, University of North Carolina at Chapel Hill and UNC Lineberger Comprehensive Cancer Center, with the 2014 Bladder Cancer Research Innovation Award to support his project “Immune Characterization of High-Grade Bladder Cancer.”
Six UNC Lineberger members are among the most often-cited scientists in the world, according to the Thomson Reuters 2014 Highly Cited Researchers list.
Cancer care in North Carolina is the focus of the July/August issue of the North Carolina Medical Journal (NCMJ). The issue, co-guest-edited by UNC Lineberger Comprehensive Cancer Center members Ethan Basch, MD, and Stephanie Wheeler, PhD, MPH, features articles on a wide variety of issues that determine how the state’s residents receive treatment for cancer.
Obesity, epidemic in the U.S. and worldwide, is one of the important modifiable risk factors for breast cancer, especially a particularly aggressive subtype called basal-like breast cancer (BBC). Population studies have suggested that lifestyle interventions, including weight loss, could prevent a large proportion of this type of cancer; however, data on the effect of weight loss on BBC risk are limited and the mechanisms involved uncertain.
Though cancer screening has come a long way, physicians still do not thoroughly discuss with patients the advantages and disadvantages of these procedures before decisions are made to undergo the screenings, according to a new study co-authored by a physician from The University of North Carolina at Chapel Hill’s Gillings School of Global Public Health.
The ability of researchers and physicians to use DNA sequencing to pinpoint the genetic mutations that cause cancer has led to greater understanding of the causes of the disease and development of drugs that treat tumors by targeting specific mutations. A pair of papers published by researchers at the UNC Lineberger Comprehensive Cancer Center reveal new tools that can improve the accuracy of tumor sequencing.
The American Society of Clinical Oncology (ASCO) has chosen Ronald Chen, MD, MPH, assistant professor of radiation oncology and member of the UNC Lineberger Comprehensive Cancer Center, as a member of the 2014-2015 ASCO Leadership Development Program.
A story that ran on Raleigh-based CBS affiliate WRAL focuses on a new bladder cancer vaccine being studied at UNC, called Impact Therapy. The vaccine works to target cancer cells with minimal side effects.
NEW YORK (Reuters Health) - When it comes to cancer screening, doctors often do not adequately discuss the balance of pros and cons with their patients, a new study suggests.
A delegation from the Tata Memorial Centre cancer hospital in Mumbai, India visited the UNC Lineberger Comprehensive Cancer Center as part of a U.S. tour visiting comprehensive cancer centers. The visit, sponsored through the National Cancer Institute’s (NCI) Liaison for International Partnerships, was intended to share knowledge about how American universities and hospitals operate a comprehensive cancer center.
Close to a dozen BB&T employees recently gave their morning to volunteer at the Patient and Family Resource Center (PFRC) at the N.C. Cancer Hospital. They came to deliver the BB&T “Comfort Cart,” a rolling cart filled with snacks to comfort and sustain cancer patients and their families while they are at the cancer hospital. They brought enough granola bars, nutrition shakes and other non-perishable snacks to keep the cart stocked for months. They also brought the gifts of housekeeping and organization.
The UNC/Rex team joined thousands of cancer survivors and supporters on Saturday, June 14th for the 18th annual Susan G. Komen Triangle Race for the Cure at Meredith College in Raleigh.
Noam Vanderwalde, MD, a radiation oncology resident at the N.C. Cancer Hospital, was awarded a 2014 Young Investigator Award by the Conquer Cancer Foundation of the American Society of Clinical Oncology (ASCO).
The discovery, from the lab of Brian Strahl, PhD, offers insights for the creation of better, more targeted therapies for various forms of cancer.
Physical activity after breast cancer diagnosis has been linked with prolonged survival and improved quality of life, but most participants in a large breast cancer study did not meet national physical activity guidelines after they were diagnosed.
Wheeler and Reeder-Hayes research shows African-American women and those insured by Medicaid less likely to receive endocrine therapy to prevent breast cancer recurrence
New research by Stephanie B. Wheeler, PhD; Katie Reeder-Hayes, MD; and Anne Marie Meyer, PhD, reveals that breast cancer patients insured by Medicaid and African-American breast cancer patients are less likely to receive life-saving endocrine therapy (ET) to prevent cancer recurrence.
More than 25 members and affiliated physicians of the UNC Lineberger Comprehensive Cancer Center will present their work to the attendees at the 2014 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, being held May 30 through June 3. The annual meeting brings together more than 25,000 oncology professionals to present research and discuss new treatment options.
CHAPEL HILL, NC - Why are some 75-year-olds downright spry while others can barely get around? Part of the explanation, according to research published today in Cell Press journal "Trends in Molecular Medicine," is differences from one person to the next in exposure to harmful substances in the environment, chemicals such as benzene, cigarette smoke, and even stress.
The UCRF, a $42 million, state-appropriated fund established in 2007, continues to have a significant impact on cancer research in North Carolina.
Virginia resident Marie Clem loves to hike. She began the activity as a way to improve her physical and mental health, and it has turned into so much more. On April 26, Marie, alongside family and friends, hiked for a different reason: to fight bone cancer.
An article on the benefits of exercise for breast cancer survivors recently published on the Runner's World website is based off of research published by UNC Lineberger member and Associate Professor of Exercise and Sport Science, Claudio Battaglini, PhD.
Personalized medicine holds great promise for delivering targeted treatments to patients based on their unique genetic characteristics. Through a $3.5 million, five-year grant from the National Cancer Institute (NCI), UNC Lineberger Comprehensive Cancer Center will provide high-throughput RNA and DNA sequencing and regulatory assistance to partner institutions in the NCI’s new National Clinical Trials Network (NCTN).
The 2014 Pancreatic Cancer Purple Stride 5K was a huge success with over $200,000 raised to support pancreatic cancer awareness and research. The event, held Saturday, May 17 on NC State's Centennial Campus, was organized by the Pancreatic Cancer Action Network. UNC Lineberger’s very own - TEAM UNC and the Der Lab Team - were the top two Purple Stride fundraising teams.
Leanne Kaye, MPH, of the UNC Department of Nutrition has been named the 2014 recipient of the Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences.
The 2014 Susan G. Komen Triangle Race for the Cure is scheduled for Saturday, June 14th on the campus of Meredith College in Raleigh, NC.
The American Cancer Society (ACS) has awarded a $480,000, two-year Research Scholar Grant to Stacie B. Dusetzina, PhD, assistant professor at the UNC School of Medicine and Gillings School of Global Public Health and member of the UNC Lineberger Comprehensive Cancer Center, to support research on the impact of parity legislation on the use and costs of oral cancer medications.
UNC Lineberger members gathered for the 9th annual UNC Lineberger Scientific Retreat on May 14 at the Carolina Club. The retreat featured lectures from Edison Liu, president and CEO of The Jackson Laboratory, a State of the LCCC address from UNC Lineberger Director Norman Sharpless and lectures from eight UNC Lineberger members.
Professor Deborah K. Mayer has been named the UNC Lineberger Director of Cancer Survivorship. In her new position, Deborah Mayer, PhD, RN, AOCN, FAAN, will lead the effort to enhance clinical and research initiatives for cancer survivors for the UNC Lineberger Comprehensive Cancer Center.
Susan G. Komen for the Cure North Carolina Triangle to the Coast Affiliate awards $50,000 grant to UNC Lineberger Comprehensive Cancer Support Program
The Susan G. Komen North Carolina Triangle to the Coast (NCTC) has awarded a $50,000 grant to UNC Lineberger Comprehensive Cancer Support Program to fund a project aimed at improving access to comprehensive lymphedema care for breast cancer patients in central North Carolina.
UNC Lineberger Board of Visitors member, Francine Netter Roberson, has written the first major biography of her father, the legendary medical illustrator, Frank Netter, MD. Medicine’s Michelangelo, The Life & Art of Frank Netter, MD (October, 2013, Quinnipiac University Press) is based on Frank Netter’s private papers and published works along with the remembrances of his family, friends and colleagues.
The UNC Lineberger Comprehensive Cancer Center will hold its 9th Annual Scientific Retreat on May 14 at the Carolina Club. The retreat will feature lectures from Edison Liu, president and CEO of The Jackson Laboratory, a State of the LCCC address from UNC Lineberger Director Norman Sharpless and lectures from eight UNC Lineberger members.
Clara Alston had a 37 year career as a newborn critical care nurse at N.C. Children’s Hospital. When Clara began working at UNC in 1975, newborn critical care units were just starting to pop up in hospitals. By the time she retired from her position as assistant nurse manager in the Newborn Critical Care Center (NCCC) in 2012, Clara was an expert in the field of newborn critical care. She often shared stories about the early days and the evolution of newborn critical care nursing.
Betty Ray McCain has given much of herself to UNC Lineberger. She has been a member of the UNC Lineberger Board of Visitors since 2005. Most recently, she served as chair of the Membership and Nominating Committee. Prior to that, she ably served as vice chair from 2007-2009 and chaired the board from 2009-2012.
Team UNC Lineberger participated in Saturday’s Bladder Cancer Advocacy Network’s (BCAN) Annual Walks for Bladder Cancer.
UNC Lineberger will be well represented at the 2014 Pancreatic Cancer Purple Stride 5K. The event, organized by the Pancreatic Cancer Action Network, helps raise awareness and research funds for pancreatic cancer.
The American Cancer Society (ACS) has named Ben Major, PhD, assistant professor with the University of North Carolina School of Medicine and UNC Lineberger Comprehensive Cancer Center member, as a 2014 Research Scholar.
The UNC Lineberger Board of Visitors elected new leaders at its spring meeting in April. Richard Stevens of Cary, NC was elected to serve as chair, and Jean Kitchin of Scotland Neck, NC will serve as vice chair. Their terms will begin on July 1, 2014.
A partnership formed by UNC Lineberger Comprehensive Cancer Center, the Duke Cancer Institute and the Siteman Cancer Center at Washington University in St. Louis will become part of a national network working to accelerate the pace of cancer drug development.
The Sidney Kimmel Foundation for Cancer Research has named Greg Wang, PhD, and Qing Zhang, PhD, as 2014 Sidney Kimmel Scholars.
Previously thought to only play a role in male fertility, the protein DAZAP1 has now been shown to be a major player in how genes are expressed; in cell culture experiments it stifled the progression of several types of cancer cells.
News and Observer article on e-cigarette regulation features UNC Centers for Tobacco Regulatory Science
A News and Observer article on the role of Triangle organizations in guiding the efforts of federal regulators crafting regulations for e-cigarettes features the work of work of UNC Lineberger members Kurt Ribisl, PhD, and Adam Goldstein, MD, MPH.
Sharpless and Kim inducted at American Association of Physicians and American Society for Clinical Investigation meeting, Rathmell elected ASCI Treasurer
Norman Sharpless, MD, Director of the UNC Lineberger Comprehensive Cancer Center has been inducted as a member of the American Association of Physicians (AAP). His induction was announced at the joint American Society for Clinical Investigation (ASCI)/American Association of Physicians meeting in Chicago.
On April 26, more than 6,000 people participated in the 7th Annual Tar Heel 10 Miler
UNC Lineberger selected to join A Survivor Action Partnership to improve the lives of prostate cancer survivors
UNC Lineberger has been selected to participate in A Survivor Action Partnership – United States of America (ASAP USA), a consortium of institutions that will collaborate to develop and study interventions to improve the lives of prostate cancer survivors in the United States. Sixteen institutions were selected following a peer reviewed application process. Ronald Chen, MD, MPH, assistant professor of radiation oncology is leading the UNC Lineberger ASAP USA team.
The Leukemia & Lymphoma Society's Man & Woman of the Year (MWOY) campaign is a national fundraising competition in which participants vie for the title of Man or Woman of the Year. They raise funds for blood cancer research in honor of local children who are blood cancer survivors. The titles are awarded to the men and women who raise the most funds during the campaign in their communities. The top local fundraisers in the country also win the national titles.
Five questions for Chuck Perou, PhD, a UNC geneticist on the hunt for better treatments for the most deadly form of breast cancer
Cell movement plays an important role in a host of biological functions from embryonic development to repairing wounded tissue. It also enables cancer cells to break free from their sites of origin and migrate throughout the body.
UNC Lineberger member Deborah K. Mayer, PhD, RN, AOCN, FAAN, was awarded $50,000 in funding through the UNC School of Medicine’s Institute for Healthcare Quality Improvement seed grant program for her proposal “Implementing Survivorship Care Plans.”
Andrew Tucker, PhD, used his graduate experience at UNC to help build a new kind of mammographic imaging machine now in use in a clinical trial at the North Carolina Cancer Hospital.
The John William Pope Foundation has made a $1.3 million gift to UNC Lineberger Comprehensive Cancer Center to fund cancer research and treatment.
UNC Lineberger member Gary Johnson, PhD, professor and chair of the UNC Department of Pharmacology, has been tapped to join Synodos, a team of scientists working together to defeat the rare genetic disorder neurofibromatosis type 2 (NF2). A first-of-its-kind NF research collaboration, Synodos has brought together centers of excellence from institutions across the country. Johnson will be just one of 12 academic researchers in the collaboration.
Please join Team Lineberger for the Bladder Cancer Advocacy Network (BCAN) annual walk to raise awareness about bladder cancer on May 3, 2014 in Hillsborough, NC.
The push and pull of physical force can cause profound changes in the behavior of a cell. Two studies from researchers working at the UNC Lineberger Comprehensive Cancer Center reveal how cells respond to mechanical manipulation.
UNC Lineberger to be involved in first research challenge using Project Data Sphere Initiative, a new data sharing platform launched by CEO Roundtable on Cancer
UNC Lineberger Comprehensive Cancer Center has contributed to the development of the first national “research challenge” involving the newly launched Project Data Sphere, LLC (PDS), an independent not-for-profit initiative of the CEO Roundtable on Cancer’s Life Sciences Consortium (LSC).
UNC Lineberger helped celebrate the opening of Marsico Hall today, the newest research building to house an impressive array of programs, including several affiliated with the cancer center.
Science Magazine interviewed UNC Lineberger members Charles Perou, PhD, and James Evans, MD, PhD, for a special feature on “The ‘Other’ Breast Cancer Genes.”
Researchers at the UNC Lineberger Comprehensive Cancer Center and the University of Texas Southwestern Medical Center will investigate the role of proteins linked both to human sexual reproduction and cancer tumor formation thanks to a grant from the U.S. Department of Defense (DoD).
Members of the UNC Lineberger Comprehensive Cancer Center will share their research and expertise at the 105th Annual Meeting of the American Association for Cancer Research (AACR) on April 5 to 9 in San Diego, Calif. The event will host more than 18,000 researchers, patient advocates and other professionals in the cancer field to share the year’s foremost basic science, translational and clinical advances.
Physicians have long suspected that chemotherapy can accelerate the aging process in patients treated for cancer. Using a test developed at UNC Lineberger Comprehensive Cancer Center to determine molecular aging, UNC oncologists have directly measured the impact of anti-cancer chemotherapy drugs on biological aging.
The University of North Carolina at Chapel Hill will dedicate Marsico Hall (formerly called the IRB building or the BRIC building) at 3:30 p.m. Thursday, March 27. The event will also begin streaming live online once the ceremony has begun.
RNA encodes the proteins that play a key role in cellular reproduction, but the manner in which cells regulate its removal once these proteins are synthesized remains a mystery. One piece of this mystery has been solved as researchers at the University of North Carolina at Chapel Hill who have identified the steps by which a cell removes RNA from the cytoplasm.
The Metastatic Breast Cancer Network (MBCN) is pleased to announce it will hold its 8th Annual National Conference September 19-21, 2014 in conjunction with the UNC Lineberger Comprehensive Cancer Center in Chapel Hill, North Carolina
Andrew Olshan, PhD, professor and chair of the UNC Gillings School of Global Public Health’s Department of Epidemiology and UNC Lineberger associate director for population sciences, has been named the Barbara Sorenson Hulka Distinguished Professor of Cancer Epidemiology, effective March 1.
A non-invasive test that includes detection of the genetic abnormalities related to cancer could significantly improve the effectiveness of colon cancer screening, according to research published by a team of scientists including David Ransohoff, MD, professor of medicine at the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center member.
On March 5, Shelia Santacroce, PhD, UNC Lineberger Comprehensive Cancer Center Member and Beerstecher-Blackwell Distinguished Scholar, received a $50,000 research grant from Northwestern Mutual and the Alex’s Lemonade Stand Foundation (ALSF) to fund children’s cancer research.
Chad Ellis, PhD, has been appointed as associate director of UNC Lineberger Comprehensive Cancer Center, effective April 1, 2014.
Cancer patients who receive care from local physicians partnering with the medical research community are as likely to receive innovative treatments compared to patients treated at medical school affiliated hospitals, according to research from the University of North Carolina at Chapel Hill.
Across the country, thousands have taken part in the Colon Cancer Coalition’s initiative called “Get Your Rear In Gear,” a series of 5K races aimed at fighting colon cancer by raising funding to support education, prevention and screening programs. On March 1, supporters gathered in Raleigh, N.C. to kick off Colorectal Cancer Awareness month with their local Get Your Rear in Gear event.
The lab of Klaus Hahn, PhD, developed a new technique to help scientists map the interactions between the proteins at the heart of many diseases.
Parham is being recognized by the Society for Gynecologic Oncology for his work on cervical cancer and selfless dedication to improving the lives of women in Zambia.
Beth Knight found out what transpires inside cells involved in medulloblastoma - a type of brain cancer - and what role a particular protein plays in tumor development.
The program prepares volunteers to provide patients and their families with practical and emotional guidance as they receive treatment.
Two UNC researchers design a biological test to individualize chemotherapy.
UNC Lineberger Comprehensive Cancer Center member Jared Weiss, MD is teaming up with the cancer advocacy organization Global Resource for Advancing Cancer Education (GRACE) to offer a free webinar
UNC Lineberger members make major contribution to President’s Cancer Panel report on HPV vaccination
Members of the University of North Carolina Lineberger Comprehensive Cancer Center played a major role in developing the recommendations in a President’s Cancer Panel (PCP) report urging a widespread public campaign to increase the rate of human papillomavirus (HPV) vaccination.
The work of UNC School of Medicine Professor and Lineberger member John Baron, MD, is featured in an article titled "Can aspiring fight cancer?" The article provides an overview of recent studies that suggest regular doses of aspirin can help prevent some types of cancer.
The oncogene RAS is linked to 30 percent of human cancers, but the search for a targeted therapy for RAS has remained elusive. Three leading RAS researchers from the University of North Carolina Lineberger Comprehensive Cancer Center are playing leading roles at a conference aimed at discussing recent advances that may lead to new advances in targeting the oncogene.
Clinical trials that show positive patient response to systemic therapies for cancer should not necessarily lead to reduction in the use of local therapies such as radiation and surgery.
The Lung Cancer Initiative of North Carolina (LCINC), the state’s leading non-profit organization supporting lung cancer research and education, is proud to welcome Dr. Jared Weiss, medical oncologist with UNC Lineberger Comprehensive Cancer Center’s Thoracic Oncology Program, to serve on the board of directors.
UNC Lineberger member Russell Harris, MD, MPH, Professor of Medicine in the UNC School of Medicine and Adjunct Professor of Epidemiology in the UNC Gillings Global School of Public Health, was quoted in two articles in the New York Times about a major study of the efficacy of breast cancer screening published by BMJ (formerly British Medical Journal).
A comprehensive genetic analysis of invasive bladder cancer tumors has found that the disease shares genetic similarities with two forms of breast cancer, according to researchers at the University of North Carolina Lineberger Cancer Center. Bladder cancer, which is the fourth most common malignancy in men and ninth most common in women in the United States, claimed more than 15,000 patients last year.
“This is an important finding because of the field’s increased interest in ‘metabolic reprogramming’ of immune cells. Understanding how macrophage substrate metabolism impacts inflammation is crucial to our being able to develop novel therapies for obesity and diabetes, and even cancer," said study author Liza Makowski, PhD, assistant professor of nutrition at the Gillings School and member of the UNC Lineberger Comprehensive Cancer Center.
UNC Lineberger receives jointly awarded $1 million research grant to investigate novel target in melanoma
The $1 million award from the Melanoma Research Alliance and the Saban Family Foundation will support research to improve the treatment of melanoma, the most aggressive type of skin cancer.
A team led by Cyrus Vaziri, PhD, and William Janzen at the University of North Carolina at Chapel Hill has received a grant from the National Institutes of Health for research that could help make chemotherapy drugs more effective.
The response of a patient with metastatic brain tumors to treatment with stereotactic radiosurgery in the first six-to-twelve weeks can indicate whether follow-up treatments and monitoring are necessary, according to research conducted at the University of North Carolina.
The UNC Lineberger Comprehensive Cancer Center announces The Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences. This cash award goes directly to the recipient and can be used for any purpose.
The journal highlights research performed by UNC Lineberger member Angela Smith, MD, that links a loss of muscle mass, known as sarcopenia, in women to complications from a cystectomy. Women who experienced sarcopenia were found to have a 43 percent chance of major complications compared to 10 percent for women who did not experience muscle loss.
While ultrasound provides a less expensive and radiation-free alternative to detecting and monitoring cancer compared to technologies such as X-rays, CT scans and MRIs, the lower clarity and resolution of ultrasound has limited its use in cancer treatment. Researchers at the University of North Carolina at Chapel Hill have overcome this limitation by combining ultrasound with a contrast agent comprised of micro-sized bubbles that pair with an antibody produced at elevated levels by many cancers.
Qi Zhang sees himself as a warrior. In his lab at the University of North Carolina at Chapel Hill, he wages war on genetic diseases such as cancer and heart disease on a battlefield measured with single atoms.
The Oncology Nursing Society Foundation selected MSN student Sean Gallagher, RN, for a 2013 APN/DNP Student Fellowship. Mr. Gallagher's fellowship will cover the costs of his research project "Survivors of HPV-Related Oropharyngeal Cancer--Knowledge of Human Papillomavirus (HPV) and Impact of HPV on Sexual Intimacy."
The annual compilation of The Best Doctors in America® includes 53 physicians affiliated with the University of North Carolina’s Lineberger Comprehensive Cancer Center.
Sha Chang, Otto Zhou, and collaborators have built the first small device that can produce these kind of microbeams, opening up a new area of research for cancer scientists.
Dr. Lisa Carey, MD, medical director of the UNC Breast Center and associate director for clinical science at UNC Lineberger Comprehensive Cancer Center, is one of the experts interviewed by MedPage Today on recent advances in cancer research.
The next chapter in the story of UNC Lineberger Comprehensive Cancer Center begins with a new director, Ned Sharpless, an oncologist with a story to tell.
The cost of insurance co-payments for cutting-edge pharmaceuticals can vary widely from patient to patient. When the patient’s share of prescription costs becomes too high, many patients skip doses or stop taking medication entirely, according to research conducted at the University of North Carolina.
The Charlotte Observer - Mersereau comments on fertility preservation for young adults battling cancer
Dr. Jennifer Mersereau, a fertility preservation specialist at UNC Cancer Care, comments on the promise and challenge of fertility preservation for individuals battling cancer.
UNC Lineberger Comprehensive Cancer Center and UNC Cancer Care honored four employees with 2013 Excellence Awards.
UNC Women's Basketball Coach Sylvia Hatchell talked to the Associated Press about her fight to get back to her basketball program as quickly as possible.
Movember is a national campaign where teams are inspired to raise money, and grow mustaches, to support men’s health.
On December 7, 2013, America’s No. 1 tennis player, John Isner, held his annual charity event, the Ebix Charity Challenge, contributing $75,000 to UNC Lineberger
Screening to detect medical conditions has become standard practice for many diseases, but insufficient attention has been paid to the potential for harm, according to research by a team led by Russell Harris, MD, MPH, of the UNC School of Medicine, UNC Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center member.
We are deeply grateful to the thousands of donors who help make UNC Lineberger’s cancer fight possible by supporting innovative and lifesaving cancer research and care. Here are important year-end gift deadlines and reminders to receive tax benefits for calendar 2014.
James Evans, MD, PhD, published his thoughts on the 23andMe genetic testing controversy in the Dec. 13 issue of The Cancer Letter.
The award recognizes Hyman B. Muss, MD, for his years of service to the Richard L. Schilsky Cancer and Leukemia Group B cooperative group.
A new study shows combined therapy is linked to a lower chance of recurrence in women with small, HER2+ breast cancers.
UNC Lineberger's Single Fathers Due to Cancer program featured in the Chapel Hill News.
The National Academy of Inventors Fellows were nominated by their peers for outstanding contributions to innovation.
UNC Lineberger members Charles Perou, PhD, Lisa Carey, MD, Carey Anders, MD, and Hyman B. Muss, MD will present at symposium.
N.C. Cancer Hospital patient, Jim MacDonald, worked with songwriter, Emily Lynch, to write a song about his cancer experience, "Every Day is Christmas.”
Five questions for Yisong Wan, PhD, a new Jefferson-Pilot fellow who is uncovering the roles of T cells in disease cures and causes.
Director of the Cancer Outcomes Research Program at the University of North Carolina Lineberger Comprehensive Cancer Center and colleagues at the FDA guide drug developers on how to include meaningful pain endpoints when designing cancer trials.
The Carolina Pediatric Attention, Love, and Support program pairs UNC students with young people undergoing treatment for cancer and blood disorders, Josephine Yurcaba of the Daily Tar Heel reports.
Bruce Ham, one of the original members of the Single Fathers Due to Cancer support group, has written a memoir, “Laughter, Tears and Braids,” about his journey raising three daughters after the death of his wife from cancer.
The largest-ever population-based study of breast cancer in North Carolina is poised to begin the five year follow-up phase.
The Tuesday after Thanksgiving is intended to create a national movement around the holidays dedicated to giving.
A new study led by Christine Rini, PhD, finds that survivors of hematopoietic stem cell transplant, an aggressive treatment for blood cancers, benefited from a two-part peer support process the authors call expressive helping.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, was quoted on National Public Radio's All Things Considered regarding the Food and Drug Administration's warning letter sent to the company 23andMe demanding that its saliva test be taken off the market.
Give back this holiday season by registering with Be The Match on UNC’s campus on December 2 and 3, 2013.
Stella Waugh, a cancer survivor, is thankful to have family together for Thanksgiving, April Dudash of the Durham Herald-Sun reports.
For the fifth straight year, UNC Libraries and campus collect books for the Pediatric Hematology-Oncology clinic.
A study of 2,519 Kenyan men conducted by researchers at the University of North Carolina revealed that infection with the human papillomavirus (HPV) was associated with a higher subsequent risk of infection with HIV, a precursor to AIDS.
A Dare County, N.C., wife and mother of three keeps her spunky, positive spirit intact during treatment for thyroid cancer, buoying herself, her family and her medical team on the journey.
William Zamboni, PharmD, PhD, has developed a probe to measure the body’s immune function to help physicians deliver accurate, individualized doses for cancer patients prescribed nanoparticle-based drugs
The inaugural geriatric oncology symposium, geared toward a lay audience, provided a lively afternoon of presentations, questions and answers, and concluded with a reception on Friday, November 15, 2013.
The award is the highest distinction awarded by the American Association of Pharmaceutical Scientists.
Der highlighted recent research findings that have stimulated new experimental directions for improve therapies for pancreatic cancer.
Women who are obese face an increased risk of developing an aggressive sub-type of breast cancer known as ‘basal-like’, according to research conducted at the University of North Carolina at Chapel Hill.
When celebrities battle cancer, their stories make headlines around the world. Whether announcing their prognosis, seeking treatment or losing their battle, celebrities faced with cancer have a profound impact on the public – one that leads to increased interest in cancer information and screening, according to research by the University of North Carolina.
Five questions for Greg Wang, a new Jefferson-Pilot fellow searching for better ways to shut down cancer cells.
In October 2013, Adam Goldstein, MD, MPH, embarked on an incredible journey taking him to the heartland of civilization's beginning.
Matthew Nielsen, MD, MS, FACS, presents on "Active Surveillance for Prostate Cancer" for the Global Grand Rounds hosted by Best Doctors.
Stereotactic body radiation therapy is an effective treatment option that is cost-effective and convenient for patients.
Book drive seeks 10,000th book for the Pediatric Oncology Clinic.
WCHL named Lisa Edwards a Hometown Hero for November 6, 2013. Each weekday the station selects a Hometown Hero who goes “over and above the call of duty,” exemplifying excellent service and dedication to others in the community.
The grant will be used to further research to globally understand regulated protein degradation and how this contributes to normal cellular functions that are dysfunctional in cancer.
GlaxoSmithKline drug-discovery competition winners aim to find a new cancer therapy and a novel way to regulate male fertility, projects spearheaded by scientists at the UNC School of Medicine.
The five-year grant recognizes the nation’s most innovative young scientists.
The three-year contract is funded by the Patient-Centered Outcomes Research Institute (PCORI).
Walking program reduces joint stiffness in older breast cancer survivors on aromatase inhibitor therapy
After six weeks of walking, the mean joint pain scores among the participants decreased by 10 percent, fatigue decreased by 19 percent, and joint stiffness decreased by 32 percent.
The Breast Cancer Research Foundation continues its longstanding support of research at UNC Lineberger with $960,000 in awards to four researchers working to discover the causes and find better treatments for breast cancer.
Help her reach her 2,000-hat goal by December 16.
Help her reach her 2,000-hat goal by December 16.
In the editorial, "Misperceptions on electronic health records" published in the News & Observer, Lawrence Marks, MD, Chair of Department of Radiation Oncology and UNC Lineberger member explains on the benefits and drawbacks of electronic health records.
UNC clinical geneticists Jonathan Berg and James Evans spearhead an ambitious project to catalog all genetic variations implicated in disease.
The UNC Lineberger-sponsored conference featured several UNC-affiliated faculty and graduates.
In the article, "Do you want to know what will kill you?" at Salon.com, Jim Evans MD, PhD, Director of Clinical Cancer Genetics and UNC Lineberger member discusses the pros and cons of consumer-marketed genetic testing.
Charles Perou’s test can help patients decide on a course of treatment.
Funds from the campaign will support programs that benefit patients and families receiving cancer treatment at the N.C. Cancer Hospital.
A new microbeam emitter developed at the University of North Carolina at Chapel Hill by a team led by UNC Lineberger member Otto Zhou has the potential to bring a promising new form of radiation therapy into clinical use.
Coach Roy Williams’ 9th annual Fast Break Against Cancer kicks off basketball season with live auction breakfast event.
Five questions for Ronald Chen, a James Woods Young Faculty Award recipient dedicated to bettering treatment for cancer patients.
Football fans gave cancer “the boot” when the Tar Heels faced off with Boston College in Kenan Stadium
Join UNC Health Care at 11:00 a.m. Eastern time on Friday, Nov. 1, for a discussion of how fathers cope with the loss of their wife or partner, meet the demands of sole parenthood, and manage their children's grief.
Only half of the men who receive a prostate cancer diagnosis consult with more than one type of physician before deciding on a course of treatment.
Sylvia Hatchell is temporarily stepping away from coaching due to a recent diagnosis of leukemia.
The University of North Carolina at Chapel Hill campus is buzzing with anticipation as the beginning of basketball season approaches this Friday, October 25. And the Tar Heels are kicking it off with support for UNC Lineberger.
Cure Cancer Starter is a nonprofit site taking the Kickstarter approach to raising funds for much-needed research and clinical trials in the fight against cancer.
American No. 1 and North Carolina native John Isner to host charity exhibition featuring Andy Roddick
Fourth Annual Ebix Charity Challenge returns to Isner’s hometown of Greensboro, N.C. on December 7, 2013.
Shelley Earp is not going anywhere, but at year’s end he will leave a position he has held for the past 16 years as director of the UNC Lineberger Comprehensive Cancer Center.
Patients with poor nutritional status before bladder cancer operation have a higher risk of postoperative complications
New ACS NSQIP® study identifies low blood albumin level as an independent risk factor for surgical-related health problems after radical cystectomy
Funds to be used for minimizing the toxicity of chemotherapy
Cowher joins Coach Williams, his assistant coaches, and Woody Durham at this seated breakfast and one-of-a-kind live auction event later this month.
Colon Cancer Coalition funds UNC Lineberger to reduce barriers to screenings for vulnerable populations
A local 5K run and walk, Get Your Rear in Gear, raises money to support colon cancer screening programs.
Peer support interventions have traditionally and successfully been used to address health promotion and prevention, such as increasing cancer screening. UNC researchers have published the first study to examine whether enhancing the skills of community-based peer support can help people living with persistent and serious illness.
Over 100 physicians, nurses, staff, and patients from UNC and Rex formed the Famous Amos team for the Third Annual Pink Shamrock 5K in Raleigh, NC.
UNC Lineberger kicked off its Blue Ribbon Gala on September 27, 2013, gathering more than 450 people to celebrate advancements in cancer care at UNC. The black-tie event raised more than $225,000 for UNC Lineberger.
The UNC School of Medicine’s Division of Hematology/Oncology held its first annual retreat on September 6, 2013 at the Rizzo Center in Chapel Hill to discuss the academic mission and future goals of the division.
New test uses PAM50 breast cancer gene signature discovered by UNC’s Perou
Post-doctoral fellows Scott Rothbart, PhD; Gidi Shemer, PhD; and Angela Wahl, PhD, are the recipients of the Joseph S. Pagano Award for a paper by a postdoctoral fellow published in 2012.
Physicians experience increased effort and uncertainty in cross-coverage of radiation oncology patients
Radiation oncology physicians who encounter an unfamiliar case when cross covering for another physician experience higher levels of perceived workload and may perhaps also effects on performance, according to research conducted at the University of North Carolina.
Prostate cancer treatment delays onset of pain and quality of life deterioration in men with metastatic prostate cancer
Abiraterone acetate, a recently FDA-approved drug used to treat men with metastatic castration-resistant prostate cancer, significantly delays progression of pain and quality of life deterioration when taken in conjunction with prednisone.
The national Pink Heals Tour visited UNC on Friday, September 20 with a fleet of pink fire trucks, a bus and emergency vehicles. Chapel Hill Fire Department, the host for the visit, brought their Carolina Blue fire truck.
Dr. Cynthia Powell of N.C. Children's Hospital and Dr. Jonathan Berg of UNC Lineberger Comprehensive Cancer Center will answer your questions in a live Facebook chat at noon (12 p.m.) Eastern time on Thursday, Sept. 26.
An 82-year-old resident of Aurora, N.C., is referred to UNC Hospitals for treatment of a nasal cavity cancer in the post of tissue between his nostrils. A multidisciplinary treatment decision, the support of his family and a stay at SECU Family House see him through.
UNC and Wake Forest awarded FDA, NIH grant to create Center for Regulatory Research on Tobacco Communications
Although cigarette use has declined among Americans, regulators face the challenge of communicating the dangers of new tobacco products along with reaching smokers in diverse communities who may not respond to traditional forms of anti-tobacco communication. To address these issues, the U.S. Food and Drug Administration (FDA) and the National Institutes of Health (NIH) announced today that they are awarding a $19.4 million, five-year grant to fund a center at the University of North Carolina that will study issues related to tobacco prevention communication and regulation.
Governor Pat McCrory and First Lady Ann McCrory proclaimed September 13 as Childhood Cancer Awareness Day in North Carolina
The Honorable Pat McCrory Governor of the State of North Carolina, and First Lady Ann McCrory visited the North Carolina Children’s Hospital on September 13 to proclaim that day as Childhood Cancer Awareness Day in North Carolina.
Dr. Oliver Smithies won the Nobel Prize for his research in gene modification. What you may not know is that since he was a child, he's been enthralled with flying.
E. Claire Dees, MD, associate professor of medicine, and Peter Voorhees, MD, associate professor of medicine, have been appointed to leadership positions in UNC Lineberger Comprehensive Cancer Center. Dr. Dees will serve as medical director of the Clinical Protocol Office and Dr. Voorhees will serve as chair of the Protocol Review Committee.
Racial disparities in the treatment and outcome of breast cancer patients arise from a combination of biological, social and financial causes. Understanding how these complex factors influence interactions between patients and the medical community is key to reducing the gaps in treatment and mortality between racial groups, according to researchers at the University of North Carolina.
As the clinical use of genomic testing expands, the practical and ethical considerations of using the technology to screen newborns for genetic conditions will be the focus of a new study undertaken at the University of North Carolina.
As a clinical nurse IV in the outpatient clinics of N.C. Cancer Hospital, Collier plays many roles from nurse manager to caring for patients. He's used to playing different roles though as he's been into drama and theater about as long as he's been in nursing
Ethan Basch, MD, Director, Cancer Outcomes Research Program at UNC Lineberger, discussed incorporating measurements of patient well-being into developing new treatments with CancerNetwork writer Anna Azvolinsky in an Aug. 28, 2013 podcast.
Encouraging physicians to recommend human papillomavirus (HPV) vaccine to adolescent boys and their parents - and educating the boys and their families about the importance of receiving the vaccine - are essential to reducing the cancers this virus can cause.
David Ollila, MD, professor of surgery, has been appointed to the James H. and Jesse E. Millis Distinguished Professorship. The $1.5 million professorship was established by their son, William (Bill) Millis in honor of his parents, Jim and Jesse Millis of High Point, N.C.
The North Carolina Biotechnology Center awarded more than $460,000 in grants to support research and infrastructure needs of members of the UNC Lineberger Comprehensive Cancer Center researching cancer and cell biology.
An article in the New York Times Magazine profiled work by Barbara L. Fredrickson, Kenan Distinguished Professor of psychology in the College of Arts and Sciences, in partnership with Steven Cole, PhD, Professor of Medicine and Psychiatry and Biobehavioral Sciences in the University of California Los Angeles School of Medicine, into the genomic effects of happiness.
On August 20, 2013, UNC Lineberger held a reception to honor Charles M. “Chuck” Perou, PhD, for his 2013 Hyman L. Battle Distinguished Cancer Research Award.
Katy Jones has been hired as director of communications and marketing for the UNC Lineberger Comprehensive Cancer Center, effective August 19, 2013.
William Roper, MD, MPH, Dean of the School of Medicine, Vice Chancellor for Medical Affairs, and CEO of University of North Carolina Health Care System, announces the appointment of Norman "Ned" Sharpless, MD, as director of the University of North Carolina Lineberger Comprehensive Cancer Center, effective January 1, 2014.
UNC Lineberger scientists Blossom Damania, PhD, Dirk Dittmer, PhD, and Liza Makowski, PhD, have been awarded two-year National Cancer Institute Provocative Questions grants.
"Scientists say blueberries powerful antioxidants and anthocyanins make them one of nature's top cancer fighters, two things that hit home for North Carolina women's basketball coach Sylvia Hatchell."
A team of researchers has published their analysis of survival rates among study participants in the 2003 Prostate Cancer Prevention Trial showing that the prostate drug finasteride does not decrease survival after a diagnosis of prostate cancer. Their 2003 publication found that while the drug finasteride significantly reduced the risk of prostate cancer, it was associated with an increased risk of high-grade disease and possibly decreased survival.
Like a toddler in need of a nap or a snack, the cells of our bodies can turn a bit sour under conditions of stress or nutrient deprivation. The pH levels inside these cells – starved, perhaps by a heart attack or other injury – have been known to drop dramatically in a cry for help.
Researchers at the University of North Carolina and the National Institutes for Health have defined the role of the protein vinculin in enabling cell movement. In a paper published in the Journal of Cell Biology, Sharon Campbell, PhD, professor of Biochemistry and Biophysics and member of UNC Lineberger Comprehensive Cancer Center, and Clare Waterman of the National Heart, Lung and Blood Institute at the National Institutes of Health showed that cell mobility occurs through the interactions between the protein vinculin and the cytoskeletal lattice formed by the protein actin. By physically binding to the actin that makes up the cytoskeleton, vinculin operates as a form of molecular clutch transferring force and controlling cell motion.
A rapidly-dissolvable microneedle patch developed by a UNC team led by Joseph DeSimone, William R. Kenan, Jr. Distinguished Professor of Chemistry and Chemical Engineering, and director of the UNC Institute for Advanced Materials, Nanoscience, and Technology and member of UNC Lineberger, allows for painless injections of medicine and vaccines.
Bob Goldstein, PhD, professor of biology, talks about his career and the promise of cell biology in a profile in the August issue of The Journal of Cell Biology.
Human bodies recognize at the molecular level that not all happiness is created equal, responding in ways that can help or hinder physical health, according to new research led by Barbara L. Fredrickson, Kenan Distinguished Professor of psychology in the College of Arts and Sciences at the University of North Carolina at Chapel Hill.
Since 2011, the University of North Carolina has partnered with the government of Malawi to establish a pathology laboratory in the nation’s capital, building on an existing decades-long collaboration. The laboratory has provided an invaluable service to patients and has also built capacity at a national teaching hospital, according to an analysis of the first 20 months of operation published August 7 online by PLOS ONE.
UNC Gazette - Oliver Smithies and Nobuyo Maeda were born in island countries half a world apart – he in England, she in Japan – but each in their own way found a path to a life in science.
Susan G. Komen for the Cure has awarded more than $800,000 to researchers with the UNC Lineberger Comprehensive Cancer Center to fund research into fighting cancer.
The tyrosine kinase MerTK plays a prominent role in the body’s immune response. MerTK signaling helps “calm” the body’s first line of immunity, the macrophage, while it performs the routine duties - clearing cells that die and healing damaged tissue.
Brian Burnham is an assistant scout master and one of the leaders of Troop 845's Lucky 13 Bike Trip, a fundraiser for UNC Lineberger.
Research that developed a method of visualizing aging and tumor growth in mice by Norman Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Deputy Cancer Center Director, was featured in an article on biological markers of aging in the New York Times.
UCRF Competitive Grants Program 2013 Innovation Awards were chosen from 51 applications. The awards provided $1,180,000 to support research among the six winners.
WRAL features Bill McCulloch, known as Windy City Slim, a blues singer who learned to reclaim his voice after treatment from head and neck cancer caused his vocal muscles to atrophy.
The National Institute of Health has awarded University of North Carolina researcher Lishan Su, PhD, with a $2 million four-year R01 grant to investigate using a novel immune therapy to treat chronic hepatitis B virus (HBV) infection.
Jahan Mohiuddin developed a tool to determine a patient’s risk of breast cancer relapse.
Albert Baldwin, PhD, Professor of Biology and Associate Director of Basic Research at UNC Lineberger discusses the regulation and biological functions of NF-κB in cancer at OncLive.
A 65-year-old Person County man is successfully treated for a rare head and neck cancer, but the treatment side effects damaged his teeth and gums. He may have lost his pearly whites, but not his spirit or his faith.
Shellie Ellis, MA, and Shelley Golden, PhD, of the Gillings School of Global Public Health are the 2013 recipients of the Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences.
RNA Diagnostic Test from Paraffin Improves Lung Cancer Diagnosis Over Routine Microscopic Evaluation Alone
Knowing what type of lung cancer a patient has is critical to determine which drug will work best and which therapies are safest in the era of personalized medicine. Key to making that judgment is an adequate tumor specimen for the pathologist to determine the tumor’s histology, a molecular description of a tumor based on the appearance of cells under a microscope. But not all specimens are perfect, and are sometimes so complex that a definitive diagnosis presents a challenge.
Stephanie Wheeler, PhD, assistant professor of health policy and management at Gillings School of Global Public Health, will receive $727,000 over five years through an American Cancer Society Mentored Research Scholar Grant.
National quality assessment programs usually measure and reward practices based on improving clinical processes such as re-hospitalization or infection rates. While this type of information is important and useful to clinicians, it doesn’t always take into account what is most important to the patient and families of the patient receiving care, such as the management of long-term symptoms or ability to conduct daily activities.
For decades, women between the ages of 21 and 69 were advised to get annual screening exams for cervical cancer. In 2009, however, accumulating scientific evidence led major guideline groups to agree on a new recommendation that women be screened less frequently: every three years rather than annually.
Different factors influence delay between diagnosis and first course of treatment for breast cancer for African-American and White women.
UNC has lost a dear colleague. Dr. Keith Amos died suddenly in Edinburgh, Scotland, while on a Dr. Claude Organ, Jr., Travel Award from the American College of Surgeons. We all hold in our thoughts his wife, Ahaji, and their three young daughters.
Albert Baldwin, PhD, William Rand Kenan Professor of Biology and associate director of UNC Lineberger Comprehensive Cancer Center, has received a one-year continuation grant from the Samuel Waxman Cancer Research Foundation.
For patients facing treatment for cancer, it is essential to understand how their symptoms will be affected. Symptoms like pain, fatigue, or nausea can result from the cancer, or from treatment side effects. The best way to collect this information is from patients themselves in research studies. But almost no drug labels in the U.S. include this information. As a result, incomplete information is available to patients and clinicians to help with treatment decisions.
Nurse Coordinators for the UNC Bone Marrow and Stem Cell Transplant Program show their support for Good Morning America anchor, Robin Roberts.
Researchers at the University of North Carolina at Chapel Hill and MIT have combined two novel technologies to create specialized versions of tiny, coated nanoparticles. Through the use of a special coating technique, the researchers were further able to customize highly reproducible nanoparticles made using the PRINT platform created at UNC, which enables scientists to manufacture particles in a near-infinite array of shapes, sizes and material compositions. The combination of these unique technologies may result in developing more effective medicines, efficient electronics and technological advances in many other fields.
It’s a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.
Jen Jen Yeh, MD, and Gary Johnson, PhD, were awarded a $326,708.00 grant from the Lustgarten Foundation for a one-year pilot study to investigate the kinome landscape of pancreatic cancer.
Humans and their pet dogs are close, so close that they both develop a type of cancer called diffuse large B-cell lymphoma. In humans it’s the most common lymphoma subtype while in dogs, it’s one of the most common cancers in veterinary oncology.
UNC women’s basketball Coach Sylvia Hatchell’s blueberry patch near Black Mountain, NC is ready for the summer picking season.
Kathy DeClue of Randolph County was featured in Family House Diaries in August 2012. She celebrated the success of a second stem cell transplant for leukemia by renewing her wedding vows with her husband of 41 years before 80 friends and family.
The first of its kind program, Single Fathers Due to Cancer, continues to gain attention through media reports.
This summer, ten boy scouts from Chapel Hill are biking across the country to raise money for UNC Lineberger Comprehensive Cancer Center. For every $15,000 raised, UNC Lineberger has agreed to send one of their pediatric oncology patients to spend a week at Victory Junction, a camp for chronically ill children.
HJ Kim, MD, associate professor in UNC’s division of surgical oncology and endocrinology, has been named as a member of the Society of Surgical Oncology's (SSO) Executive Council.
Clinical geneticist Jim Evans, MD, PhD helped to open the exhibition, Genome: Unlocking Life's Code. The high-tech, high-intensity display celebrates the 10th anniversary of production of the first complete human genome sequence also known as the genetic blueprint of the human body.
James Evans, MD, PhD, an international expert in gene patenting and genetics policy, comments on the June 13, 2013 Supreme Court ruling regarding gene patenting.
New research from the UNC School of Medicine has shown how a protein called UHRF1 “reads” the histone code in a specific way to perform an important cellular function.
The late Robert Craft Millikan will be honored with a 2013 Alumni Achievement Award from the University of California at Davis School of Veterinary Medicine during the School's commencement ceremony on June 14.
UNC women’s basketball Coach Sylvia Hatchell’s blueberry patch near Black Mountain, NC is almost ready for the summer picking season.
Four UNC School of Nursing students have been awarded American Cancer Society Graduate Scholarships in Cancer Nursing Practice. The recipients are Sean Gallagher, RN; April Lenker, RN; Melissa Matson, RN; and Lori Walker, RN.
Ten area teens will pedal with purpose this summer, riding some 3,700 miles over a 10-week period, from Maryland to Oregon. The group, dubbed “Lucky 13,” a play on the year “2013,” aims to raise $30,000 for UNC’s Lineberger Comprehensive Cancer Center, with a portion on the money going directly to serve pediatric cancer patients.
More than 15 members and associates of the UNC Lineberger Comprehensive Cancer Center presented their work to the attendees at the 2013 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
Pignone - Eligibility for aspirin for primary prevention in men increases when cancer mortality benefit added
While aspirin has been shown to be effective in preventing heart attacks in men, it also increases the risk of gastrointestinal bleeding and possibly stroke, even at low doses. As such, national guidelines suggest that aspirin be used for prevention only in men at higher risk for cardiovascular events, so that the benefits of aspirin are greater than its adverse effects.
More than 200 faculty, students and fellows gathered at the Carolina Club to hear ten-minute "TED talks" by 11 faculty recently recruited to UNC.
The study will focus on assessing the impact of a clinic-based intervention that includes having patients view a multimedia decision aid (in English or Spanish) before seeing their physician, as well as support from a bilingual patient “navigator” on completion of recommended colon cancer screening tests.
Dr. Carey Anders, MD, assistant professor of medicine, was interviewed in a new video on fertility preservation for female cancer patients produced by the American Society of Clinical Oncology. The video, titled “Discussing Fertility Preservation with Women,” was released in conjunction with ASCO updated guidelines and was shown at the 2013 ASCO annual meeting.
Cancer patients, physicians and insurers want to be sure that whatever therapy is recommended and provided to patients is based on evidence, preferably results from randomized clinical trials. But are there enough clinical trials data to provide this level of confidence?
While the mutated KRAS oncogene is associated with many cancers, it has not yet been successfully targeted by a therapeutic agent. Scientists are trying to find another way to target the gene by blocking signals from another protein downstream.
Smith - Worldwide cervical cancer prevention initiative announced at Women Deliver Conference in Malaysia
Cervical cancer kills an estimated 275,000 women each year, and most of these deaths could be prevented with prophylactic HPV vaccination, routine cervical cancer screening and continuity to treatment. At the Women Deliver Conference in Kuala Lumpur, Malaysia, delegates and experts from around the world announced a global call to action to combat this preventable disease through collaboration with and information sharing by the world’s governments and health agencies on May 27, 2013.
The protein GATA-3 plays an important role in mammalian immune response, but its overall function in cell development and cancer formation is not well understood. In an effort to further define the importance of GATA-3, researchers at the University of North Carolina have traced how the protein performs important functions in CD8+T-cell type of the immune system.
Intensity-modulated radiation therapy has become the most commonly used type of radiation in prostate cancer, but research from the University of North Carolina suggests that the therapy may not be more effective than older, less expensive forms of radiation therapy in patients who have had a prostatectomy.
Charles Perou, PhD, the May Goldman Shaw Distinguished Professor of Molecular Oncology, has been honored with the 2013 Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research. Dr. Perou is a member of UNC Lineberger Comprehensive Cancer Center.
University of North Carolina School of Medicine researchers uncover surprising insights about how nerve cells rewire themselves, shedding light on a process linked with neurodegenerative diseases and neurodevelopmental disorders like schizophrenia and autism.
Endeavors profiles the work of Nancy Klauber-DeMore, MD, professor of surgery and a member of UNC Lineberger, in unraveling the mystery of whether the gene SFRP2 suppresses tumor growth.
Barbara K. Rimer, DrPH, Dean and Alumni Distinguished Professor of the University of North Carolina Gillings School of Global Public Health, has been awarded the American Cancer Society (ACS) Medal of Honor for her "seminal cancer research efforts."
Claire Dees, MD, and Neil Hayes, MD, MPH, have been appointed as co-leaders of the Clinical Research Program at UNC Lineberger Comprehensive Cancer Center. Dr. Dees and Hayes have extensive and complementary expertise in translational and clinical research. As co-leaders of the Clinical Research Program, they will help plan the efforts of UNC Lineberger’s physician researchers to move discoveries into innovative trials of new therapeutic approaches.
Q&A with UNC Lineberger members James P. Evans, MD, PhD; David Ollila, MD; Paola Gehrig, MD; and Keith D. Amos, MD, FACS.
Jennifer Smith, PhD, MPH, research associate professor at the UNC Gillings School of Global Public Health and member of the UNC Lineberger Comprehensive Cancer Center, says that lack of awareness and stigma about the illness hinders prevention of the disease.
Patients must take a larger role in participating in and assisting in determining priorities for medical research, according to an editorial published in an upcoming issue of the Journal of the American Medical Association.
Hy Muss, MD, Director, Geriatric Oncology Program discusses evaluation tools for treating older patients on OncLive.
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
In Kenya, women face a cervical cancer mortality rate that is approximately 10 times as high as in the United States. A study by researchers at the University of North Carolina at Chapel Hill suggests that training women to self-collect genital samples to test for human papillomavirus (HPV), the causative agent of cervical cancer, can increase the coverage rates of cervical cancer screening. Higher screening coverage helps increase rates of detection of cervical lesions and ultimately treatment of the disease.
Raj Pruthi, MD, Chief of Urologic Surgery for the Urologic Oncology Program spoke at the annual meeting of the American Urological Association (AUA) in San Diego, California.
Close to 450 people attended the 37th annual UNC Lineberger scientific symposium April 29 and 30, 2013. Symposium co-chairs were Jonathan Serody, MD, PhD, Elizabeth Thomas Chair of Medicine, and Jenny Ting, PhD, UNC Alumni Distinguished Professor of Microbiology and Immunology. Both spoke at the symposium.
Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease. An international team, led by scientists at the University of North Carolina Lineberger Comprehensive Cancer Center, reports pre-clinical research showing improved efficacy of a PEGylated liposomal (encapsulated) anti-cancer agent compared with a non-liposomal formulation of the same drug in an intracranial model of breast cancer. Their results were published in the May 1, 2013 issue of PLOS ONE.
Associate professor Deborah Mayer, PhD, RN, AOCN, FAAN and member of UNC Lineberger has been selected as an Extraordinary Nurse Leader by Yale University, the first independent university-based nursing school established in the United States. As part of its 90th anniversary celebration, Yale School of Nursing has selected 90 alumni who “embody the School’s mission of advancing better health care” to be honored at a ceremony in October 2013.
Kurt Ribisl, PhD, head of Cancer Prevention and Control Program at the UNC Lineberger Comprehensive Cancer Center, was interviewed by National Public Radio on New York City's proposal to raise the legal age to buy cigarettes to 21.
A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.
Sethi, MacNevin, Feng come out on top at 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum
On Friday, April 19, from 2 p.m. to 4 p.m. in the MBRB at the School of Medicine, 44 university postdoctoral fellows gathered for a poster forum to present their research findings.
Dr. Harold E. Varmus, director of the National Cancer Institute at the National Institutes of Health and co-winner of the 1989 Nobel Prize in Physiology or Medicine for the discovery of the cellular origin of retroviral oncogenes, was invited to campus by UNC’s Nobel Laureate Dr. Oliver Smithies.
A team from the UNC Bone Marrow and Stem Cell Transplant Program headed up by Tippu Khan, PharmD, BCOP and Nicole Frazier, RN, BSN participated in an epic journey which included leaping over fire, trekking through waste-high mud, tossing spears, dodging attacks and most of all braving near freezing temperatures in the driving rain. What is all this about? It's the Spartan Race, an event of pure primitive craziness that promises it's participants an experience they'll never forget.