UNC Lineberger News

Dohlman lab identifies cellular distress signal

Dohlman lab identifies cellular distress signal

Like a toddler in need of a nap or a snack, the cells of our bodies can turn a bit sour under conditions of stress or nutrient deprivation. The pH levels inside these cells – starved, perhaps by a heart attack or other injury – have been known to drop dramatically in a cry for help.

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NIH and UNC Researchers Define Role of Protein Vinculin in Cell Movement

Researchers at the University of North Carolina and the National Institutes for Health have defined the role of the protein vinculin in enabling cell movement. In a paper published in the Journal of Cell Biology, Sharon Campbell, PhD, professor of Biochemistry and Biophysics and member of UNC Lineberger Comprehensive Cancer Center, and Clare Waterman of the National Heart, Lung and Blood Institute at the National Institutes of Health showed that cell mobility occurs through the interactions between the protein vinculin and the cytoskeletal lattice formed by the protein actin. By physically binding to the actin that makes up the cytoskeleton, vinculin operates as a form of molecular clutch transferring force and controlling cell motion.

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DeSimone microneedle patch featured in ScienceNews

A rapidly-dissolvable microneedle patch developed by a UNC team led by Joseph DeSimone, William R. Kenan, Jr. Distinguished Professor of Chemistry and Chemical Engineering, and director of the UNC Institute for Advanced Materials, Nanoscience, and Technology and member of UNC Lineberger, allows for painless injections of medicine and vaccines.

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Goldstein profiled in The Journal of Cell Biology

Bob Goldstein, PhD, professor of biology, talks about his career and the promise of cell biology in a profile in the August issue of The Journal of Cell Biology.

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Human cells respond in healthy, unhealthy ways to different kinds of happiness

Human bodies recognize at the molecular level that not all happiness is created equal, responding in ways that can help or hinder physical health, according to new research led by Barbara L. Fredrickson, Kenan Distinguished Professor of psychology in the College of Arts and Sciences at the University of North Carolina at Chapel Hill.

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UNC-Malawi cancer pathology laboratory is a model for Sub-Saharan Africa

Since 2011, the University of North Carolina has partnered with the government of Malawi to establish a pathology laboratory in the nation’s capital, building on an existing decades-long collaboration. The laboratory has provided an invaluable service to patients and has also built capacity at a national teaching hospital, according to an analysis of the first 20 months of operation published August 7 online by PLOS ONE.

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Smithies - Separate research paths lead to a lifelong partnership

Smithies - Separate research paths lead to a lifelong partnership

UNC Gazette - Oliver Smithies and Nobuyo Maeda were born in island countries half a world apart – he in England, she in Japan – but each in their own way found a path to a life in science.

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Komen awards more than $800,000 to UNC Lineberger researchers

Komen awards more than $800,000 to UNC Lineberger researchers

Susan G. Komen for the Cure has awarded more than $800,000 to researchers with the UNC Lineberger Comprehensive Cancer Center to fund research into fighting cancer.

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Inhibiting Macrophage MerTK Signaling Creates an Innate Immune Response Against Cancer

The tyrosine kinase MerTK plays a prominent role in the body’s immune response. MerTK signaling helps “calm” the body’s first line of immunity, the macrophage, while it performs the routine duties - clearing cells that die and healing damaged tissue.

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Brian Burnham of Lucky 13 wins WCHL's Hometown Hero Award

Brian Burnham is an assistant scout master and one of the leaders of Troop 845's Lucky 13 Bike Trip, a fundraiser for UNC Lineberger.

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