The oncogene RAS is linked to 30 percent of human cancers, but the search for a targeted therapy for RAS has remained elusive. Three leading RAS researchers from the University of North Carolina Lineberger Comprehensive Cancer Center are playing leading roles at a conference aimed at discussing recent advances that may lead to new advances in targeting the oncogene.
Clinical trials that show positive patient response to systemic therapies for cancer should not necessarily lead to reduction in the use of local therapies such as radiation and surgery.
The Lung Cancer Initiative of North Carolina (LCINC), the state’s leading non-profit organization supporting lung cancer research and education, is proud to welcome Dr. Jared Weiss, medical oncologist with UNC Lineberger Comprehensive Cancer Center’s Thoracic Oncology Program, to serve on the board of directors.
UNC Lineberger member Russell Harris, MD, MPH, Professor of Medicine in the UNC School of Medicine and Adjunct Professor of Epidemiology in the UNC Gillings Global School of Public Health, was quoted in two articles in the New York Times about a major study of the efficacy of breast cancer screening published by BMJ (formerly British Medical Journal).
A comprehensive genetic analysis of invasive bladder cancer tumors has found that the disease shares genetic similarities with two forms of breast cancer, according to researchers at the University of North Carolina Lineberger Cancer Center. Bladder cancer, which is the fourth most common malignancy in men and ninth most common in women in the United States, claimed more than 15,000 patients last year.
“This is an important finding because of the field’s increased interest in ‘metabolic reprogramming’ of immune cells. Understanding how macrophage substrate metabolism impacts inflammation is crucial to our being able to develop novel therapies for obesity and diabetes, and even cancer," said study author Liza Makowski, PhD, assistant professor of nutrition at the Gillings School and member of the UNC Lineberger Comprehensive Cancer Center.
UNC Lineberger receives jointly awarded $1 million research grant to investigate novel target in melanoma
The $1 million award from the Melanoma Research Alliance and the Saban Family Foundation will support research to improve the treatment of melanoma, the most aggressive type of skin cancer.
A team led by Cyrus Vaziri, PhD, and William Janzen at the University of North Carolina at Chapel Hill has received a grant from the National Institutes of Health for research that could help make chemotherapy drugs more effective.
The response of a patient with metastatic brain tumors to treatment with stereotactic radiosurgery in the first six-to-twelve weeks can indicate whether follow-up treatments and monitoring are necessary, according to research conducted at the University of North Carolina.
The UNC Lineberger Comprehensive Cancer Center announces The Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences. This cash award goes directly to the recipient and can be used for any purpose.
The journal highlights research performed by UNC Lineberger member Angela Smith, MD, that links a loss of muscle mass, known as sarcopenia, in women to complications from a cystectomy. Women who experienced sarcopenia were found to have a 43 percent chance of major complications compared to 10 percent for women who did not experience muscle loss.
While ultrasound provides a less expensive and radiation-free alternative to detecting and monitoring cancer compared to technologies such as X-rays, CT scans and MRIs, the lower clarity and resolution of ultrasound has limited its use in cancer treatment. Researchers at the University of North Carolina at Chapel Hill have overcome this limitation by combining ultrasound with a contrast agent comprised of micro-sized bubbles that pair with an antibody produced at elevated levels by many cancers.
Qi Zhang sees himself as a warrior. In his lab at the University of North Carolina at Chapel Hill, he wages war on genetic diseases such as cancer and heart disease on a battlefield measured with single atoms.
The Oncology Nursing Society Foundation selected MSN student Sean Gallagher, RN, for a 2013 APN/DNP Student Fellowship. Mr. Gallagher's fellowship will cover the costs of his research project "Survivors of HPV-Related Oropharyngeal Cancer--Knowledge of Human Papillomavirus (HPV) and Impact of HPV on Sexual Intimacy."
The annual compilation of The Best Doctors in America® includes 53 physicians affiliated with the University of North Carolina’s Lineberger Comprehensive Cancer Center.
Sha Chang, Otto Zhou, and collaborators have built the first small device that can produce these kind of microbeams, opening up a new area of research for cancer scientists.
Dr. Lisa Carey, MD, medical director of the UNC Breast Center and associate director for clinical science at UNC Lineberger Comprehensive Cancer Center, is one of the experts interviewed by MedPage Today on recent advances in cancer research.
The next chapter in the story of UNC Lineberger Comprehensive Cancer Center begins with a new director, Ned Sharpless, an oncologist with a story to tell.
The cost of insurance co-payments for cutting-edge pharmaceuticals can vary widely from patient to patient. When the patient’s share of prescription costs becomes too high, many patients skip doses or stop taking medication entirely, according to research conducted at the University of North Carolina.
The Charlotte Observer - Mersereau comments on fertility preservation for young adults battling cancer
Dr. Jennifer Mersereau, a fertility preservation specialist at UNC Cancer Care, comments on the promise and challenge of fertility preservation for individuals battling cancer.
UNC Lineberger Comprehensive Cancer Center and UNC Cancer Care honored four employees with 2013 Excellence Awards.
UNC Women's Basketball Coach Sylvia Hatchell talked to the Associated Press about her fight to get back to her basketball program as quickly as possible.
Movember is a national campaign where teams are inspired to raise money, and grow mustaches, to support men’s health.
On December 7, 2013, America’s No. 1 tennis player, John Isner, held his annual charity event, the Ebix Charity Challenge, contributing $75,000 to UNC Lineberger
Screening to detect medical conditions has become standard practice for many diseases, but insufficient attention has been paid to the potential for harm, according to research by a team led by Russell Harris, MD, MPH, of the UNC School of Medicine, UNC Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center member.
We are deeply grateful to the thousands of donors who help make UNC Lineberger’s cancer fight possible by supporting innovative and lifesaving cancer research and care. Here are important year-end gift deadlines and reminders to receive tax benefits for calendar 2014.
James Evans, MD, PhD, published his thoughts on the 23andMe genetic testing controversy in the Dec. 13 issue of The Cancer Letter.
The award recognizes Hyman B. Muss, MD, for his years of service to the Richard L. Schilsky Cancer and Leukemia Group B cooperative group.
A new study shows combined therapy is linked to a lower chance of recurrence in women with small, HER2+ breast cancers.
UNC Lineberger's Single Fathers Due to Cancer program featured in the Chapel Hill News.
The National Academy of Inventors Fellows were nominated by their peers for outstanding contributions to innovation.
UNC Lineberger members Charles Perou, PhD, Lisa Carey, MD, Carey Anders, MD, and Hyman B. Muss, MD will present at symposium.
N.C. Cancer Hospital patient, Jim MacDonald, worked with songwriter, Emily Lynch, to write a song about his cancer experience, "Every Day is Christmas.”
Five questions for Yisong Wan, PhD, a new Jefferson-Pilot fellow who is uncovering the roles of T cells in disease cures and causes.
Director of the Cancer Outcomes Research Program at the University of North Carolina Lineberger Comprehensive Cancer Center and colleagues at the FDA guide drug developers on how to include meaningful pain endpoints when designing cancer trials.
The Carolina Pediatric Attention, Love, and Support program pairs UNC students with young people undergoing treatment for cancer and blood disorders, Josephine Yurcaba of the Daily Tar Heel reports.
Bruce Ham, one of the original members of the Single Fathers Due to Cancer support group, has written a memoir, “Laughter, Tears and Braids,” about his journey raising three daughters after the death of his wife from cancer.
The largest-ever population-based study of breast cancer in North Carolina is poised to begin the five year follow-up phase.
The Tuesday after Thanksgiving is intended to create a national movement around the holidays dedicated to giving.
A new study led by Christine Rini, PhD, finds that survivors of hematopoietic stem cell transplant, an aggressive treatment for blood cancers, benefited from a two-part peer support process the authors call expressive helping.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, was quoted on National Public Radio's All Things Considered regarding the Food and Drug Administration's warning letter sent to the company 23andMe demanding that its saliva test be taken off the market.
Give back this holiday season by registering with Be The Match on UNC’s campus on December 2 and 3, 2013.
Stella Waugh, a cancer survivor, is thankful to have family together for Thanksgiving, April Dudash of the Durham Herald-Sun reports.
For the fifth straight year, UNC Libraries and campus collect books for the Pediatric Hematology-Oncology clinic.
A study of 2,519 Kenyan men conducted by researchers at the University of North Carolina revealed that infection with the human papillomavirus (HPV) was associated with a higher subsequent risk of infection with HIV, a precursor to AIDS.
A Dare County, N.C., wife and mother of three keeps her spunky, positive spirit intact during treatment for thyroid cancer, buoying herself, her family and her medical team on the journey.
William Zamboni, PharmD, PhD, has developed a probe to measure the body’s immune function to help physicians deliver accurate, individualized doses for cancer patients prescribed nanoparticle-based drugs
The inaugural geriatric oncology symposium, geared toward a lay audience, provided a lively afternoon of presentations, questions and answers, and concluded with a reception on Friday, November 15, 2013.
The award is the highest distinction awarded by the American Association of Pharmaceutical Scientists.
Der highlighted recent research findings that have stimulated new experimental directions for improve therapies for pancreatic cancer.
Women who are obese face an increased risk of developing an aggressive sub-type of breast cancer known as ‘basal-like’, according to research conducted at the University of North Carolina at Chapel Hill.
When celebrities battle cancer, their stories make headlines around the world. Whether announcing their prognosis, seeking treatment or losing their battle, celebrities faced with cancer have a profound impact on the public – one that leads to increased interest in cancer information and screening, according to research by the University of North Carolina.
Five questions for Greg Wang, a new Jefferson-Pilot fellow searching for better ways to shut down cancer cells.
In October 2013, Adam Goldstein, MD, MPH, embarked on an incredible journey taking him to the heartland of civilization's beginning.
Matthew Nielsen, MD, MS, FACS, presents on "Active Surveillance for Prostate Cancer" for the Global Grand Rounds hosted by Best Doctors.
Stereotactic body radiation therapy is an effective treatment option that is cost-effective and convenient for patients.
Book drive seeks 10,000th book for the Pediatric Oncology Clinic.
WCHL named Lisa Edwards a Hometown Hero for November 6, 2013. Each weekday the station selects a Hometown Hero who goes “over and above the call of duty,” exemplifying excellent service and dedication to others in the community.
The grant will be used to further research to globally understand regulated protein degradation and how this contributes to normal cellular functions that are dysfunctional in cancer.
GlaxoSmithKline drug-discovery competition winners aim to find a new cancer therapy and a novel way to regulate male fertility, projects spearheaded by scientists at the UNC School of Medicine.
The five-year grant recognizes the nation’s most innovative young scientists.
The three-year contract is funded by the Patient-Centered Outcomes Research Institute (PCORI).
Walking program reduces joint stiffness in older breast cancer survivors on aromatase inhibitor therapy
After six weeks of walking, the mean joint pain scores among the participants decreased by 10 percent, fatigue decreased by 19 percent, and joint stiffness decreased by 32 percent.
The Breast Cancer Research Foundation continues its longstanding support of research at UNC Lineberger with $960,000 in awards to four researchers working to discover the causes and find better treatments for breast cancer.
Help her reach her 2,000-hat goal by December 16.
Help her reach her 2,000-hat goal by December 16.
In the editorial, "Misperceptions on electronic health records" published in the News & Observer, Lawrence Marks, MD, Chair of Department of Radiation Oncology and UNC Lineberger member explains on the benefits and drawbacks of electronic health records.
UNC clinical geneticists Jonathan Berg and James Evans spearhead an ambitious project to catalog all genetic variations implicated in disease.
The UNC Lineberger-sponsored conference featured several UNC-affiliated faculty and graduates.
In the article, "Do you want to know what will kill you?" at Salon.com, Jim Evans MD, PhD, Director of Clinical Cancer Genetics and UNC Lineberger member discusses the pros and cons of consumer-marketed genetic testing.
Charles Perou’s test can help patients decide on a course of treatment.
Funds from the campaign will support programs that benefit patients and families receiving cancer treatment at the N.C. Cancer Hospital.
A new microbeam emitter developed at the University of North Carolina at Chapel Hill by a team led by UNC Lineberger member Otto Zhou has the potential to bring a promising new form of radiation therapy into clinical use.
Coach Roy Williams’ 9th annual Fast Break Against Cancer kicks off basketball season with live auction breakfast event.
Five questions for Ronald Chen, a James Woods Young Faculty Award recipient dedicated to bettering treatment for cancer patients.
Football fans gave cancer “the boot” when the Tar Heels faced off with Boston College in Kenan Stadium
Join UNC Health Care at 11:00 a.m. Eastern time on Friday, Nov. 1, for a discussion of how fathers cope with the loss of their wife or partner, meet the demands of sole parenthood, and manage their children's grief.
Only half of the men who receive a prostate cancer diagnosis consult with more than one type of physician before deciding on a course of treatment.
Sylvia Hatchell is temporarily stepping away from coaching due to a recent diagnosis of leukemia.
The University of North Carolina at Chapel Hill campus is buzzing with anticipation as the beginning of basketball season approaches this Friday, October 25. And the Tar Heels are kicking it off with support for UNC Lineberger.
Cure Cancer Starter is a nonprofit site taking the Kickstarter approach to raising funds for much-needed research and clinical trials in the fight against cancer.
American No. 1 and North Carolina native John Isner to host charity exhibition featuring Andy Roddick
Fourth Annual Ebix Charity Challenge returns to Isner’s hometown of Greensboro, N.C. on December 7, 2013.
Shelley Earp is not going anywhere, but at year’s end he will leave a position he has held for the past 16 years as director of the UNC Lineberger Comprehensive Cancer Center.
Patients with poor nutritional status before bladder cancer operation have a higher risk of postoperative complications
New ACS NSQIP® study identifies low blood albumin level as an independent risk factor for surgical-related health problems after radical cystectomy
Funds to be used for minimizing the toxicity of chemotherapy
Cowher joins Coach Williams, his assistant coaches, and Woody Durham at this seated breakfast and one-of-a-kind live auction event later this month.
Colon Cancer Coalition funds UNC Lineberger to reduce barriers to screenings for vulnerable populations
A local 5K run and walk, Get Your Rear in Gear, raises money to support colon cancer screening programs.
Peer support interventions have traditionally and successfully been used to address health promotion and prevention, such as increasing cancer screening. UNC researchers have published the first study to examine whether enhancing the skills of community-based peer support can help people living with persistent and serious illness.
Over 100 physicians, nurses, staff, and patients from UNC and Rex formed the Famous Amos team for the Third Annual Pink Shamrock 5K in Raleigh, NC.
UNC Lineberger kicked off its Blue Ribbon Gala on September 27, 2013, gathering more than 450 people to celebrate advancements in cancer care at UNC. The black-tie event raised more than $225,000 for UNC Lineberger.
The UNC School of Medicine’s Division of Hematology/Oncology held its first annual retreat on September 6, 2013 at the Rizzo Center in Chapel Hill to discuss the academic mission and future goals of the division.
New test uses PAM50 breast cancer gene signature discovered by UNC’s Perou
Post-doctoral fellows Scott Rothbart, PhD; Gidi Shemer, PhD; and Angela Wahl, PhD, are the recipients of the Joseph S. Pagano Award for a paper by a postdoctoral fellow published in 2012.
Physicians experience increased effort and uncertainty in cross-coverage of radiation oncology patients
Radiation oncology physicians who encounter an unfamiliar case when cross covering for another physician experience higher levels of perceived workload and may perhaps also effects on performance, according to research conducted at the University of North Carolina.
Prostate cancer treatment delays onset of pain and quality of life deterioration in men with metastatic prostate cancer
Abiraterone acetate, a recently FDA-approved drug used to treat men with metastatic castration-resistant prostate cancer, significantly delays progression of pain and quality of life deterioration when taken in conjunction with prednisone.
The national Pink Heals Tour visited UNC on Friday, September 20 with a fleet of pink fire trucks, a bus and emergency vehicles. Chapel Hill Fire Department, the host for the visit, brought their Carolina Blue fire truck.
Dr. Cynthia Powell of N.C. Children's Hospital and Dr. Jonathan Berg of UNC Lineberger Comprehensive Cancer Center will answer your questions in a live Facebook chat at noon (12 p.m.) Eastern time on Thursday, Sept. 26.
An 82-year-old resident of Aurora, N.C., is referred to UNC Hospitals for treatment of a nasal cavity cancer in the post of tissue between his nostrils. A multidisciplinary treatment decision, the support of his family and a stay at SECU Family House see him through.
UNC and Wake Forest awarded FDA, NIH grant to create Center for Regulatory Research on Tobacco Communications
Although cigarette use has declined among Americans, regulators face the challenge of communicating the dangers of new tobacco products along with reaching smokers in diverse communities who may not respond to traditional forms of anti-tobacco communication. To address these issues, the U.S. Food and Drug Administration (FDA) and the National Institutes of Health (NIH) announced today that they are awarding a $19.4 million, five-year grant to fund a center at the University of North Carolina that will study issues related to tobacco prevention communication and regulation.
Governor Pat McCrory and First Lady Ann McCrory proclaimed September 13 as Childhood Cancer Awareness Day in North Carolina
The Honorable Pat McCrory Governor of the State of North Carolina, and First Lady Ann McCrory visited the North Carolina Children’s Hospital on September 13 to proclaim that day as Childhood Cancer Awareness Day in North Carolina.
Dr. Oliver Smithies won the Nobel Prize for his research in gene modification. What you may not know is that since he was a child, he's been enthralled with flying.
E. Claire Dees, MD, associate professor of medicine, and Peter Voorhees, MD, associate professor of medicine, have been appointed to leadership positions in UNC Lineberger Comprehensive Cancer Center. Dr. Dees will serve as medical director of the Clinical Protocol Office and Dr. Voorhees will serve as chair of the Protocol Review Committee.
Racial disparities in the treatment and outcome of breast cancer patients arise from a combination of biological, social and financial causes. Understanding how these complex factors influence interactions between patients and the medical community is key to reducing the gaps in treatment and mortality between racial groups, according to researchers at the University of North Carolina.
As the clinical use of genomic testing expands, the practical and ethical considerations of using the technology to screen newborns for genetic conditions will be the focus of a new study undertaken at the University of North Carolina.
As a clinical nurse IV in the outpatient clinics of N.C. Cancer Hospital, Collier plays many roles from nurse manager to caring for patients. He's used to playing different roles though as he's been into drama and theater about as long as he's been in nursing
Ethan Basch, MD, Director, Cancer Outcomes Research Program at UNC Lineberger, discussed incorporating measurements of patient well-being into developing new treatments with CancerNetwork writer Anna Azvolinsky in an Aug. 28, 2013 podcast.
Encouraging physicians to recommend human papillomavirus (HPV) vaccine to adolescent boys and their parents - and educating the boys and their families about the importance of receiving the vaccine - are essential to reducing the cancers this virus can cause.
David Ollila, MD, professor of surgery, has been appointed to the James H. and Jesse E. Millis Distinguished Professorship. The $1.5 million professorship was established by their son, William (Bill) Millis in honor of his parents, Jim and Jesse Millis of High Point, N.C.
The North Carolina Biotechnology Center awarded more than $460,000 in grants to support research and infrastructure needs of members of the UNC Lineberger Comprehensive Cancer Center researching cancer and cell biology.
An article in the New York Times Magazine profiled work by Barbara L. Fredrickson, Kenan Distinguished Professor of psychology in the College of Arts and Sciences, in partnership with Steven Cole, PhD, Professor of Medicine and Psychiatry and Biobehavioral Sciences in the University of California Los Angeles School of Medicine, into the genomic effects of happiness.
On August 20, 2013, UNC Lineberger held a reception to honor Charles M. “Chuck” Perou, PhD, for his 2013 Hyman L. Battle Distinguished Cancer Research Award.
Katy Jones has been hired as director of communications and marketing for the UNC Lineberger Comprehensive Cancer Center, effective August 19, 2013.
William Roper, MD, MPH, Dean of the School of Medicine, Vice Chancellor for Medical Affairs, and CEO of University of North Carolina Health Care System, announces the appointment of Norman "Ned" Sharpless, MD, as director of the University of North Carolina Lineberger Comprehensive Cancer Center, effective January 1, 2014.
UNC Lineberger scientists Blossom Damania, PhD, Dirk Dittmer, PhD, and Liza Makowski, PhD, have been awarded two-year National Cancer Institute Provocative Questions grants.
"Scientists say blueberries powerful antioxidants and anthocyanins make them one of nature's top cancer fighters, two things that hit home for North Carolina women's basketball coach Sylvia Hatchell."
A team of researchers has published their analysis of survival rates among study participants in the 2003 Prostate Cancer Prevention Trial showing that the prostate drug finasteride does not decrease survival after a diagnosis of prostate cancer. Their 2003 publication found that while the drug finasteride significantly reduced the risk of prostate cancer, it was associated with an increased risk of high-grade disease and possibly decreased survival.
Like a toddler in need of a nap or a snack, the cells of our bodies can turn a bit sour under conditions of stress or nutrient deprivation. The pH levels inside these cells – starved, perhaps by a heart attack or other injury – have been known to drop dramatically in a cry for help.
Researchers at the University of North Carolina and the National Institutes for Health have defined the role of the protein vinculin in enabling cell movement. In a paper published in the Journal of Cell Biology, Sharon Campbell, PhD, professor of Biochemistry and Biophysics and member of UNC Lineberger Comprehensive Cancer Center, and Clare Waterman of the National Heart, Lung and Blood Institute at the National Institutes of Health showed that cell mobility occurs through the interactions between the protein vinculin and the cytoskeletal lattice formed by the protein actin. By physically binding to the actin that makes up the cytoskeleton, vinculin operates as a form of molecular clutch transferring force and controlling cell motion.
A rapidly-dissolvable microneedle patch developed by a UNC team led by Joseph DeSimone, William R. Kenan, Jr. Distinguished Professor of Chemistry and Chemical Engineering, and director of the UNC Institute for Advanced Materials, Nanoscience, and Technology and member of UNC Lineberger, allows for painless injections of medicine and vaccines.
Bob Goldstein, PhD, professor of biology, talks about his career and the promise of cell biology in a profile in the August issue of The Journal of Cell Biology.
Human bodies recognize at the molecular level that not all happiness is created equal, responding in ways that can help or hinder physical health, according to new research led by Barbara L. Fredrickson, Kenan Distinguished Professor of psychology in the College of Arts and Sciences at the University of North Carolina at Chapel Hill.
Since 2011, the University of North Carolina has partnered with the government of Malawi to establish a pathology laboratory in the nation’s capital, building on an existing decades-long collaboration. The laboratory has provided an invaluable service to patients and has also built capacity at a national teaching hospital, according to an analysis of the first 20 months of operation published August 7 online by PLOS ONE.
UNC Gazette - Oliver Smithies and Nobuyo Maeda were born in island countries half a world apart – he in England, she in Japan – but each in their own way found a path to a life in science.
Susan G. Komen for the Cure has awarded more than $800,000 to researchers with the UNC Lineberger Comprehensive Cancer Center to fund research into fighting cancer.
The tyrosine kinase MerTK plays a prominent role in the body’s immune response. MerTK signaling helps “calm” the body’s first line of immunity, the macrophage, while it performs the routine duties - clearing cells that die and healing damaged tissue.
Brian Burnham is an assistant scout master and one of the leaders of Troop 845's Lucky 13 Bike Trip, a fundraiser for UNC Lineberger.
Research that developed a method of visualizing aging and tumor growth in mice by Norman Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Deputy Cancer Center Director, was featured in an article on biological markers of aging in the New York Times.
UCRF Competitive Grants Program 2013 Innovation Awards were chosen from 51 applications. The awards provided $1,180,000 to support research among the six winners.
WRAL features Bill McCulloch, known as Windy City Slim, a blues singer who learned to reclaim his voice after treatment from head and neck cancer caused his vocal muscles to atrophy.
The National Institute of Health has awarded University of North Carolina researcher Lishan Su, PhD, with a $2 million four-year R01 grant to investigate using a novel immune therapy to treat chronic hepatitis B virus (HBV) infection.
Jahan Mohiuddin developed a tool to determine a patient’s risk of breast cancer relapse.
Albert Baldwin, PhD, Professor of Biology and Associate Director of Basic Research at UNC Lineberger discusses the regulation and biological functions of NF-κB in cancer at OncLive.
A 65-year-old Person County man is successfully treated for a rare head and neck cancer, but the treatment side effects damaged his teeth and gums. He may have lost his pearly whites, but not his spirit or his faith.
Shellie Ellis, MA, and Shelley Golden, PhD, of the Gillings School of Global Public Health are the 2013 recipients of the Marci Kramish Campbell Dissertation Award, a competitive $5,000 award to recognize excellence in dissertation research focused on cancer and the population sciences.
RNA Diagnostic Test from Paraffin Improves Lung Cancer Diagnosis Over Routine Microscopic Evaluation Alone
Knowing what type of lung cancer a patient has is critical to determine which drug will work best and which therapies are safest in the era of personalized medicine. Key to making that judgment is an adequate tumor specimen for the pathologist to determine the tumor’s histology, a molecular description of a tumor based on the appearance of cells under a microscope. But not all specimens are perfect, and are sometimes so complex that a definitive diagnosis presents a challenge.
Stephanie Wheeler, PhD, assistant professor of health policy and management at Gillings School of Global Public Health, will receive $727,000 over five years through an American Cancer Society Mentored Research Scholar Grant.
National quality assessment programs usually measure and reward practices based on improving clinical processes such as re-hospitalization or infection rates. While this type of information is important and useful to clinicians, it doesn’t always take into account what is most important to the patient and families of the patient receiving care, such as the management of long-term symptoms or ability to conduct daily activities.
For decades, women between the ages of 21 and 69 were advised to get annual screening exams for cervical cancer. In 2009, however, accumulating scientific evidence led major guideline groups to agree on a new recommendation that women be screened less frequently: every three years rather than annually.
Different factors influence delay between diagnosis and first course of treatment for breast cancer for African-American and White women.
UNC has lost a dear colleague. Dr. Keith Amos died suddenly in Edinburgh, Scotland, while on a Dr. Claude Organ, Jr., Travel Award from the American College of Surgeons. We all hold in our thoughts his wife, Ahaji, and their three young daughters.
Albert Baldwin, PhD, William Rand Kenan Professor of Biology and associate director of UNC Lineberger Comprehensive Cancer Center, has received a one-year continuation grant from the Samuel Waxman Cancer Research Foundation.
For patients facing treatment for cancer, it is essential to understand how their symptoms will be affected. Symptoms like pain, fatigue, or nausea can result from the cancer, or from treatment side effects. The best way to collect this information is from patients themselves in research studies. But almost no drug labels in the U.S. include this information. As a result, incomplete information is available to patients and clinicians to help with treatment decisions.
Nurse Coordinators for the UNC Bone Marrow and Stem Cell Transplant Program show their support for Good Morning America anchor, Robin Roberts.
Researchers at the University of North Carolina at Chapel Hill and MIT have combined two novel technologies to create specialized versions of tiny, coated nanoparticles. Through the use of a special coating technique, the researchers were further able to customize highly reproducible nanoparticles made using the PRINT platform created at UNC, which enables scientists to manufacture particles in a near-infinite array of shapes, sizes and material compositions. The combination of these unique technologies may result in developing more effective medicines, efficient electronics and technological advances in many other fields.
It’s a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.
Jen Jen Yeh, MD, and Gary Johnson, PhD, were awarded a $326,708.00 grant from the Lustgarten Foundation for a one-year pilot study to investigate the kinome landscape of pancreatic cancer.
Humans and their pet dogs are close, so close that they both develop a type of cancer called diffuse large B-cell lymphoma. In humans it’s the most common lymphoma subtype while in dogs, it’s one of the most common cancers in veterinary oncology.
UNC women’s basketball Coach Sylvia Hatchell’s blueberry patch near Black Mountain, NC is ready for the summer picking season.
Kathy DeClue of Randolph County was featured in Family House Diaries in August 2012. She celebrated the success of a second stem cell transplant for leukemia by renewing her wedding vows with her husband of 41 years before 80 friends and family.
The first of its kind program, Single Fathers Due to Cancer, continues to gain attention through media reports.
This summer, ten boy scouts from Chapel Hill are biking across the country to raise money for UNC Lineberger Comprehensive Cancer Center. For every $15,000 raised, UNC Lineberger has agreed to send one of their pediatric oncology patients to spend a week at Victory Junction, a camp for chronically ill children.
HJ Kim, MD, associate professor in UNC’s division of surgical oncology and endocrinology, has been named as a member of the Society of Surgical Oncology's (SSO) Executive Council.
Clinical geneticist Jim Evans, MD, PhD helped to open the exhibition, Genome: Unlocking Life's Code. The high-tech, high-intensity display celebrates the 10th anniversary of production of the first complete human genome sequence also known as the genetic blueprint of the human body.
James Evans, MD, PhD, an international expert in gene patenting and genetics policy, comments on the June 13, 2013 Supreme Court ruling regarding gene patenting.
New research from the UNC School of Medicine has shown how a protein called UHRF1 “reads” the histone code in a specific way to perform an important cellular function.
The late Robert Craft Millikan will be honored with a 2013 Alumni Achievement Award from the University of California at Davis School of Veterinary Medicine during the School's commencement ceremony on June 14.
UNC women’s basketball Coach Sylvia Hatchell’s blueberry patch near Black Mountain, NC is almost ready for the summer picking season.
Four UNC School of Nursing students have been awarded American Cancer Society Graduate Scholarships in Cancer Nursing Practice. The recipients are Sean Gallagher, RN; April Lenker, RN; Melissa Matson, RN; and Lori Walker, RN.
Ten area teens will pedal with purpose this summer, riding some 3,700 miles over a 10-week period, from Maryland to Oregon. The group, dubbed “Lucky 13,” a play on the year “2013,” aims to raise $30,000 for UNC’s Lineberger Comprehensive Cancer Center, with a portion on the money going directly to serve pediatric cancer patients.
More than 15 members and associates of the UNC Lineberger Comprehensive Cancer Center presented their work to the attendees at the 2013 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
Pignone - Eligibility for aspirin for primary prevention in men increases when cancer mortality benefit added
While aspirin has been shown to be effective in preventing heart attacks in men, it also increases the risk of gastrointestinal bleeding and possibly stroke, even at low doses. As such, national guidelines suggest that aspirin be used for prevention only in men at higher risk for cardiovascular events, so that the benefits of aspirin are greater than its adverse effects.
More than 200 faculty, students and fellows gathered at the Carolina Club to hear ten-minute "TED talks" by 11 faculty recently recruited to UNC.
The study will focus on assessing the impact of a clinic-based intervention that includes having patients view a multimedia decision aid (in English or Spanish) before seeing their physician, as well as support from a bilingual patient “navigator” on completion of recommended colon cancer screening tests.
Dr. Carey Anders, MD, assistant professor of medicine, was interviewed in a new video on fertility preservation for female cancer patients produced by the American Society of Clinical Oncology. The video, titled “Discussing Fertility Preservation with Women,” was released in conjunction with ASCO updated guidelines and was shown at the 2013 ASCO annual meeting.
Cancer patients, physicians and insurers want to be sure that whatever therapy is recommended and provided to patients is based on evidence, preferably results from randomized clinical trials. But are there enough clinical trials data to provide this level of confidence?
While the mutated KRAS oncogene is associated with many cancers, it has not yet been successfully targeted by a therapeutic agent. Scientists are trying to find another way to target the gene by blocking signals from another protein downstream.
Smith - Worldwide cervical cancer prevention initiative announced at Women Deliver Conference in Malaysia
Cervical cancer kills an estimated 275,000 women each year, and most of these deaths could be prevented with prophylactic HPV vaccination, routine cervical cancer screening and continuity to treatment. At the Women Deliver Conference in Kuala Lumpur, Malaysia, delegates and experts from around the world announced a global call to action to combat this preventable disease through collaboration with and information sharing by the world’s governments and health agencies on May 27, 2013.
The protein GATA-3 plays an important role in mammalian immune response, but its overall function in cell development and cancer formation is not well understood. In an effort to further define the importance of GATA-3, researchers at the University of North Carolina have traced how the protein performs important functions in CD8+T-cell type of the immune system.
Intensity-modulated radiation therapy has become the most commonly used type of radiation in prostate cancer, but research from the University of North Carolina suggests that the therapy may not be more effective than older, less expensive forms of radiation therapy in patients who have had a prostatectomy.
Charles Perou, PhD, the May Goldman Shaw Distinguished Professor of Molecular Oncology, has been honored with the 2013 Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research. Dr. Perou is a member of UNC Lineberger Comprehensive Cancer Center.
University of North Carolina School of Medicine researchers uncover surprising insights about how nerve cells rewire themselves, shedding light on a process linked with neurodegenerative diseases and neurodevelopmental disorders like schizophrenia and autism.
Endeavors profiles the work of Nancy Klauber-DeMore, MD, professor of surgery and a member of UNC Lineberger, in unraveling the mystery of whether the gene SFRP2 suppresses tumor growth.
Barbara K. Rimer, DrPH, Dean and Alumni Distinguished Professor of the University of North Carolina Gillings School of Global Public Health, has been awarded the American Cancer Society (ACS) Medal of Honor for her "seminal cancer research efforts."
Claire Dees, MD, and Neil Hayes, MD, MPH, have been appointed as co-leaders of the Clinical Research Program at UNC Lineberger Comprehensive Cancer Center. Dr. Dees and Hayes have extensive and complementary expertise in translational and clinical research. As co-leaders of the Clinical Research Program, they will help plan the efforts of UNC Lineberger’s physician researchers to move discoveries into innovative trials of new therapeutic approaches.
Q&A with UNC Lineberger members James P. Evans, MD, PhD; David Ollila, MD; Paola Gehrig, MD; and Keith D. Amos, MD, FACS.
Jennifer Smith, PhD, MPH, research associate professor at the UNC Gillings School of Global Public Health and member of the UNC Lineberger Comprehensive Cancer Center, says that lack of awareness and stigma about the illness hinders prevention of the disease.
Patients must take a larger role in participating in and assisting in determining priorities for medical research, according to an editorial published in an upcoming issue of the Journal of the American Medical Association.
Hy Muss, MD, Director, Geriatric Oncology Program discusses evaluation tools for treating older patients on OncLive.
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
In Kenya, women face a cervical cancer mortality rate that is approximately 10 times as high as in the United States. A study by researchers at the University of North Carolina at Chapel Hill suggests that training women to self-collect genital samples to test for human papillomavirus (HPV), the causative agent of cervical cancer, can increase the coverage rates of cervical cancer screening. Higher screening coverage helps increase rates of detection of cervical lesions and ultimately treatment of the disease.
Raj Pruthi, MD, Chief of Urologic Surgery for the Urologic Oncology Program spoke at the annual meeting of the American Urological Association (AUA) in San Diego, California.
Close to 450 people attended the 37th annual UNC Lineberger scientific symposium April 29 and 30, 2013. Symposium co-chairs were Jonathan Serody, MD, PhD, Elizabeth Thomas Chair of Medicine, and Jenny Ting, PhD, UNC Alumni Distinguished Professor of Microbiology and Immunology. Both spoke at the symposium.
Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease. An international team, led by scientists at the University of North Carolina Lineberger Comprehensive Cancer Center, reports pre-clinical research showing improved efficacy of a PEGylated liposomal (encapsulated) anti-cancer agent compared with a non-liposomal formulation of the same drug in an intracranial model of breast cancer. Their results were published in the May 1, 2013 issue of PLOS ONE.
Associate professor Deborah Mayer, PhD, RN, AOCN, FAAN and member of UNC Lineberger has been selected as an Extraordinary Nurse Leader by Yale University, the first independent university-based nursing school established in the United States. As part of its 90th anniversary celebration, Yale School of Nursing has selected 90 alumni who “embody the School’s mission of advancing better health care” to be honored at a ceremony in October 2013.
Kurt Ribisl, PhD, head of Cancer Prevention and Control Program at the UNC Lineberger Comprehensive Cancer Center, was interviewed by National Public Radio on New York City's proposal to raise the legal age to buy cigarettes to 21.
A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.
Sethi, MacNevin, Feng come out on top at 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum
On Friday, April 19, from 2 p.m. to 4 p.m. in the MBRB at the School of Medicine, 44 university postdoctoral fellows gathered for a poster forum to present their research findings.
Dr. Harold E. Varmus, director of the National Cancer Institute at the National Institutes of Health and co-winner of the 1989 Nobel Prize in Physiology or Medicine for the discovery of the cellular origin of retroviral oncogenes, was invited to campus by UNC’s Nobel Laureate Dr. Oliver Smithies.
A team from the UNC Bone Marrow and Stem Cell Transplant Program headed up by Tippu Khan, PharmD, BCOP and Nicole Frazier, RN, BSN participated in an epic journey which included leaping over fire, trekking through waste-high mud, tossing spears, dodging attacks and most of all braving near freezing temperatures in the driving rain. What is all this about? It's the Spartan Race, an event of pure primitive craziness that promises it's participants an experience they'll never forget.
Kerry Steven Bloom, Thad L. Beyle Distinguished Professor of biology at the University of North Carolina at Chapel Hill, has been elected to the American Academy of Arts and Sciences, one of the nation’s oldest and most prestigious honorary societies and a leading center for independent policy research.
Health reporter for the New York Times, Jane Brody, features the Single Fathers Due to Cancer program.
Transcription factors regulating blood oxygen linked to melanoma metastases
A Dare County real estate agent refuses to let a breast cancer diagnosis and its treatment detract from her trademark sense of humor and constant outreach to others.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted about a case before the U.S. Supreme Court involving Myriad Genetics attempts to patent two human genes related to breast and ovarian cancer.
Researchers at the University of North Carolina at Chapel Hill School of Medicine have "rationally rewired" some of the cell's smallest components to create proteins that can be switched on or off by command. These "protein switches" can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease.
UNC Lineberger was well represented at the American Association for Cancer Research Annual Meeting held in Washington, DC.
A team led by Dr. Stanley Lemon discovered that hepatitis A virus does not have an envelope when found in the environment, but acquires one from the cells that it grows in within the liver. It circulates in the blood completely cloaked in these membranes.
Lisa A. Carey, MD, Medical Director of the UNC Breast Center, the Chief of Hematology/Oncology, the Physician-in-Chief of the N.C. Cancer Hospital, and UNC Lineberger member, discusses the use of everolimus in the metastatic and adjuvant settings of breast cancer.
Neil Hayes, MD, MPH, associate professor in UNC's Division of Hematology and Oncology, presented on the patterns of genomic alterations in head and neck squamous cell carcinomas (HNSCC) at the AACR's 2013 Annual Meeting in Washington, D.C.
Satish Gopal, MD, MPH, assistant professor in the divisions of hematology/oncology and infectious diseases at the UNC School of Medicine, describes his experiences in assisting Kamuzu Central Hospital in the creation of a lab to diagnose and research cancer in Malawi.
The accomplishment provides a much-needed resource for scientists eager to uncover the true mechanisms of human stem cell biology. It also enables them to explore new tactics to treat inflammatory bowel disease or to ameliorate the side effects of chemotherapy and radiation, which often damage the gut.
Cancer patients at UNC and Duke have one less thing to worry about, thanks to the recently launched Cancer Pro Bono Legal Project. This cutting-edge collaboration among the law schools and cancer centers at the two universities and the North Carolina Bar Association offers free legal services to local cancer patients. The project has won funding from the Kenan Biddle Foundation as well as the North Carolina Bar Foundation.
Hyman B. Muss, MD, Professor of Medicine, Director of Geriatric Oncology, Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill School of Medicine, discusses the need for a team environment when treating an older patient at OncLive.
African American men on average wait a week longer than their Caucasian counterparts between the initial diagnosis of prostate cancer and treatment, according to University of North Carolina researchers.
Men who have dependent children and whose spouses or partners died from cancer are an overlooked population. These fathers face unique challenges not addressed by traditional grief support groups that often attract an older, female population.
NBC's Today Show spotlighted the first-of-its-kind program designed to help single dad's who have lost a spouse to cancer. NBC’s Dr. Nancy Snyderman reports on the group's efforts.
Research conducted in fruit flies at the University of North Carolina School of Medicine has pinpointed a specific DNA sequence that both triggers the formation of the “histone locus body” and turns on all the histone genes in the entire block.
Craven County resident, Cindy Sills, has alveolar rhabdomyosarcoma, a cancerous tumor of the muscles that are attached to bones. She and her husband work to raise awareness of rare rare soft-tissue cancer.
James Evans, director of UNC's Clinical Cancer Genetics program and UNC Lineberger member, says it is time for a public health strategy that focuses on genetic testing of healthy adults.
Barbara Fredrickson, professor of psychology and UNC Lineberger member, writes in an editorial in the New York Times that the physical and psychological tools that allow us to relate to others can diminish with lack of use.
Oliver Smithies did not set out to become one of the world’s foremost pioneers in cancer research. He merely had a question that needed answering.
“It’s a lifesaver.” That’s how Frances Patterson, a breast cancer patient, describes the therapy she receives for lymphedema through the UNC Comprehensive Cancer Support Program.
Researchers at the University of North Carolina at Chapel Hill have discovered that a protein found in the cells surrounding pancreatic cancers play a role in the spread of the disease to other parts of the body.
Ribisl predicts that new regulations preventing the open display of cigarettes in stores could lead to a reduction in smoking over time.
Debbie Dibbert, Director of External Affairs at UNC Lineberger, was named as a Hometown Hero by WCHL 97.9 and Chapelboro.com.
Jenny Ting, PhD, W.R. Kenan, Jr. Distinguished Professor of Microbiology and Immunology, has been awarded a 2013 University Award for the Advancement of Women.
Michael Pignone, MD, MPH, Professor of Medicine and Division Chief of General Medicine and Epidemiology, has been named director of the UNC Institute for Health Care Quality Improvement, which aims to establish UNC as the leading academic medical center in the area of clinical quality improvement. The new institute is a product of the UNC School of Medicine’s Strategic Plan.
For the first time, a population-based study of a human papillomavirus (HPV) vaccine has proven that the vaccine is effective in reducing the incidence of genital warts.
Two members of the UNC Lineberger Comprehensive Cancer Center have been elected as 2013 Fellows of the American Academy of Microbiology (AAM), the honorific leadership group within the American Society for Microbiology (ASM).
A study by Karyn Stitzenberg, MD, MPH, assistant professor of surgery and member of the UNC Lineberger Comprehensive Cancer Center, shows that surgical oncologists comprise only a small portion of the number of surgeons who perform cancer surgery.
The School ranked 1st in Primary Care and 22nd in Research overall in the 2014 U.S. News & World Report Best Medical School Rankings. Family Medicine, Rural Medicine and AIDS were also listed as top ten specialties.
To meet a growing need for nurses with advanced training, the University of North Carolina and five other UNC-system schools will offer a doctorate in nursing this fall. The News and Observer article discusses the need and role that will be filled by the new Doctors of Nursing Practice.
The journal Oncology's online Cancer Network profiled an address given by Hyman Muss, MD, professor of medicine, at the 30th Annual Miami Breast Cancer Conference in March.
Researchers at the University of North Carolina at Chapel Hill have discovered how helper molecules, or chaperones, aid in the RNA folding process, resolving a fundamental conundrum about how these important biological molecules work.
New chemical probe provides tool to investigate role of malignant brain tumor domains in chromatin structure and regulation
In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC Eshelman School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain. The probe, named UNC1215, will provide researchers with a powerful tool to investigate the function of malignant brain tumor (MBT) domain proteins in biology and disease.
Experts from the UNC School of Medicine and the UNC Gillings School of Global Public Health propose that screening healthy adults for preventable diseases such as colorectal cancer, breast cancer, and several catastrophic blood vessel disorders, among others, could potentially prevent these diseases.
A UNC Lineberger-affiliated program that provides HIV and cervical cancer testing in Malawi and Zambia was featured on the Raleigh-Durham ABC affiliate.
Could glowing rodents come to the aid of cancer researchers … and patients?
Head and neck squamous cell carcinoma (HNSCC) is the seventh most common form of cancer in the United States, but other than an association with the human papillomavirus, no validated molecular profile of the disease has been established. By analyzing data from DNA microarrays, a UNC-led team has completed a study that confirms the presence of four molecular classes of the disease and extends previous results by suggesting that there may be an underlying connection between the molecular classes and observed genomic events, some of which affect known cancer genes. The clinical relevance of the classes and certain genomic events was demonstrated, thus paving the way for further studies and possible targeted therapies.
James Evans, Bryson Distinguished Professor of Genetics and Medicine, was interviewed about his work as principal investigator on the NCGENES Study with WCOM 103.5's Radio In Vivo.
More than 70 kidney cancer patients and their families participated in the Kidney Cancer Association’s patient and survivor conference held at the Friday Continuing Education Center in Chapel Hill on February 23.
Triple-negative breast cancers are more biologically diverse than previously believed and classification should be expanded to reflect this heterogeneity, according to University of North Carolina researchers.
The publication names the cancer center as one of the top 100 oncology programs in the nation.
Inflammatory response plays a major role in both health protection and disease generation. While the symptoms of disease-related inflammatory response have been know, scientists have not understood the mechanisms that underlie it.
The article profiles Russell Tatum, a father who found emotional support for himself and his family through the UNC Lineberger-supported group designed for fathers who have lost a spouse to cancer.
Michael Pignone will join fellow experts in evidence-based medicine from many health-related fields to rigorously review existing peer-reviewed evidence and evaluating the benefits and harms of preventive services.
Preclinical study shows potential of new technologies to detect response to cancer therapy earlier
A set of towlettes developed by two researchers at Carolina can safely remove difficult-to-clean anticancer drugs commonly found on surfaces in hospitals, pharmacies, clinics and labs. The product, called Hazardous Drug Clean – or HDClean – addresses the growing concern regarding the safety of health care workers who frequently handle these potentially dangerous drugs.
The Triangle Business Journal has named two UNC Lineberger members as finalists for the 2013 Health Care Heroes Awards.
North Carolina’s community colleges are important settings for educating and training our citizens. Can they also play a role in preventing cancer? A group of UNC researchers recently looked into the question of whether community colleges could spread the latest evidence-based cancer and wellness information to the thousands of employees and students of the state’s community college system.
Leah Ranney, PhD, associate director of the UNC Tobacco Prevention and Evaluation Program, and Adam Goldstein, MD, professor in UNC Family Medicine and director of the Tobacco Prevention and Evaluation Program, published the following editorial on the social benefits of anti-smoking policies and tobacco-use prevention programs:
Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) hide within the worldwide human population. While dormant in the vast majority of those infected, these active herpesviruses can develop into several forms of cancer. In an effort to understand and eventually develop treatments for these viruses, researchers at the University of North Carolina have identified a family of human genes known as Tousled-like kinases (TLKs) that play a key role in the suppression and activation of these viruses.
Ethan Basch, MD, MSc, Director of Cancer Outcomes Research at the UNC Lineberger Comprehensive Cancer Center, has been appointed by the Director of the National Cancer Institute to serve on the Board of Scientific Advisors (BSA).
What’s most important to a man as he decides whether or not to undergo prostate-specific antigen- PSA- screening for prostate cancer? What does he value most about the screening? And what’s the best way to present the information to help him make an appropriate decision for himself?
In a study published in the January 18 issue of Cell, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have developed a new method to visualize aging and tumor growth in mice using a gene closely linked to these processes.
More than 150 physicians and patients gathered February 6th and 7th to learn more about melanoma. Melanoma Patient Day, February 6, was a half-day symposium sponsored by the Melanoma Research Foundation, the UNC Division of Surgical Oncology and the UNC Department of Dermatology. Meeting co-chairs were Drs. David Ollila, professor of surgery, and Nancy Thomas, Robert Alan and Irene Briggaman Distinguished Professor of Dermatology.
Worldwide, many strains of the bacterium Staphyloccocus aureus are already resistant to all antibiotics except vancomycin. But as bacteria are becoming resistant to this once powerful antidote, S. aureus has moved one step closer to becoming an unstoppable killer. Now, researchers at the University of North Carolina at Chapel Hill have not only identified the mechanism by which vancomycin resistance spreads from one bacterium to the next, but also have suggested ways to potentially stop the transfer.
UNC researchers find a way to unlock the secrets of DNA’s dark matter.
A new study from the University of North Carolina published January 25, 2013 in the journal Genome Medicine reveals the huge diversity of U.S. biobanks and also raises questions about the best way to manage and govern them
The Triad Golfers Against Cancer has awarded two grants to researchers at the UNC Lineberger Comprehensive Cancer Center totaling $65,000.
A University of North Carolina School of Medicine study may have implications for thwarting the effects of bioterrorism attack with lethal microbes, as well as finding a way to save people in septic shock, an overwhelming bacterial infection of the blood.
The Scientist Magazine has featured recent research by Timothy Gershon, MD, PhD, on the link between brain tumors and glycolysis.
The 2012 University Cancer Research Fund Innovation Awards recognize six University of North Carolina researchers for groundbreaking cancer research. The UCRF Innovation Awards are designed to support innovation, collaboration and cancer-focused science across a broad spectrum of the cancer-research community at UNC.
Norman Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Deputy Cancer Center Director, discussed the development of a mouse model to study aging and cancer with WUNC's Frank Stasio.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, spoke to National Public Radio's All Things Considered about the need to find a balance between making genetic data available to researchers and protecting patient privacy.
Dr. Qi Zhang receives the 2013 Basil O’Connor Starter Scholar Research Award from the March of Dimes Foundation.
Joseph DeSimone, PhD, was awarded the 2012 Watson Chubb Award for Innovation from the Sigma Xi, The Scientific Research Society. The award honors creativity among scientists and engineers.
A 2009 survey by UNC faculty of North Carolina middle and high schoolers found that 79 percent support smoke-free areas and other smoking bans.
The best approach to detecting cervical cancer in HIV-positive women living in research limited countries such as those in Sub-Saharan Africa combines commonly used testing methods tailored to local levels of development and medical infrastructure, according to a study by researchers from and the University of Witwatersrand in South Africa and the University of North Carolina.
Jenny Ting, PhD, Alumni Distinguished Professor in UNC’s Department of Microbiology and Immunology and member of UNC Lineberger, has been awarded the American Association of Immunologist’s Life Technologies Meritorious Career Award for 2013.
This month's focus is on the ever-popular mode of entertainment enjoyed throughout the centuries: the theater. Keith Burridge, a Kenan Professor of Cell Biology and Physiology, is also a playwright. His most recent play, The Art of Deception, is based on a true story of a dutch painter, Han van Meegeren.
CHAPEL HILL, N.C. – Research findings from the University of North Carolina School of Medicine are shining a light on an important regulatory role performed by the so-called dark matter, or “junk DNA,” within each of our genes.
Endeavors: Yang finds new link between health and connectivity to friends, family, and social groups
From UNC Endeavors - The arthritis and chronic back pain are so intense that the patient can barely get through the day. The patient’s blood work reveals that his body is in a state of chronic inflammation, a sign that his immune system is working too hard. Doctors prescribe medication, which helps a little, but it won’t address one contributing factor that sociologist Yang Yang says doctors aren’t trained to consider.
The Komen Foundation named Hyman B. Muss, MD, Professor of Medicine and the Director of the Geriatric Oncology Program at University of North Carolina Lineberger Comprehensive Cancer Center in Chapel Hill as one of two recipients of their Brinker Ward in 2012.
Satish Gopal, MD, MPH, assistant professor in the divisions of hematology/oncology and infectious diseases at the UNC School of Medicine, has been awarded a 2012 AIDS Malignancy Consortium (AMC) fellowship. The fellowship helps foster the careers of new and junior investigators whose work involves clinical research trials on HIV-associated malignancies in resource-limited settings.
Wang discovers information from outside the genome influences stem cell differentiation, cancer development
Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.
Use the links below to find the news archives.
Dr. Carey talks about the importance of cancer research and her new role as Chief of the Division of Hematology and Oncology and Physician-in-Chief of the N.C. Cancer Hospital.
N.E.D. - a rock band comprised of gynecologic oncology physicians - was featured in the New York Times' health and science blog.
The American Association for Cancer Research and Kure It have announced that William Y. Kim, MD, will receive a 2012 AACR-Kure It Grant for Kidney Cancer Research.
Nikolay Dokholyan, PhD, Professor of Biochemistry and Biophysics and member of the UNC Lineberger Comprehensive Cancer Center, was elected as a 2012 Fellow of the American Physical Society. The Dokholyan lab studies the physical nature of interactions between atoms, molecules, cells, and organisms. The underlying question throughout their research is how these interactions shape the complex organization, behavior, and evolution of biomolecules and organisms.
Hepatitis C virus has evolved to invade and hijack the basic machinery of the human liver cell to ensure its survival and spread. Researchers at the University of North have discovered how hepatitis C binds with and repurposes a basic component of cellular metabolism known as a microRNA to help protect and replicate the virus.
The UNC Global Oncology Program held its third annual retreat on December 14 at the Friday Center. Led by Dr. Blossom Damania, Director of the UNC Lineberger Global Oncology Program, and Dr. Dirk Dittmer, Program Resource Director for the program, close to 80 program members from the UNC Center for AIDS Research and UNC Lineberger shared their research.
For Dr. Neil Hayes “the best part of being a scientist is the people. Here at UNC, it’s the leadership we have for the cancer center in clinical fields, the wonderful scientists across the country who we collaborate with, and our patients.”
Dr. Lisa Carey, Marilyn Jacobs Preyer Distinguished Professor in Breast Cancer Research, and Barbara Martin, Health-e-NC Project Director, will discuss surviving breast cancer on the next episode of UNC’s Your Health with Adam & Cristy.
ABC 11 recently featured the UNC Comprehensive Cancer Support Program's Caregiver Support Group.
The UNC Lineberger Geriatric Oncology Program held its third annual retreat on November 29 at the Friday Center. Program members presented research and heard scientific presentations from colleagues at Duke and Wake Forest Universities. The group then discussed areas of possible collaboration.
Kurt Ribisl, PhD, has been appointed to lead the Cancer Prevention and Control Program at the UNC Lineberger Comprehensive Cancer Center.
An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively make designer drugs that hit multiple protein targets at once.
Brook Zickus’ wedding bouquet featured an unusual “something blue”: a UNC Lineberger ribbon-foot pin.
Basch discusses the value of patient-reported data in comparative effectiveness research in two webinars Dec. 11 and 12
Ethan Basch, MD, Director of the Cancer Outcomes Research Program at UNC Lineberger Comprehensive Cancer Center, will be speaking in two webinars on comparative effectiveness on Tuesday, Dec. 11 and Wednesday, Dec. 12.
The annual compilation of The Best Doctors in America® includes more than 60 physicians affiliated with the University of North Carolina’s Lineberger Comprehensive Cancer Center.
Yang Yang, PhD, associate professor of sociology and member of UNC Lineberger, was quoted about a Journal of Urology study that found that men have a higher death rate from cancer.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, was quoted on National Public Radio's All Things Considered discussing a report in American Journal of Human Genetics finding that healthy people have many genetic mutations.
Terry Magnuson served on an Institute of Medicine commission tasked to review the progress of California’s state-funded regenerative medicine initiative focused on stem cell research.
Chapel Hill, NC – Norman E. “Ned” Sharpless, MD, has been appointed Deputy Director of the UNC Lineberger Comprehensive Cancer Center. Dr. Sharpless is the Wellcome Distinguished Professor in Cancer Research, professor of medicine and genetics.
Federico Innocenti, MD, PhD, received the 2013 Leon I. Goldberg Young Investigator Award from the American Society for Clinical Pharmacology and Therapeutics. Innocenti, associate director for oncology research in the UNC Institute for Pharmacogenomics and Individualized Therapy and a member of UNC Lineberger, was recognized for his work in individualizing therapy for cancer patients.
The American Association for the Advancement of Science has awarded three UNC Lineberger Comprehensive Cancer Center members the distinction of AAAS 2012 Fellow. The three were among four UNC School of Medicine Faculty honored.
Stacey Anderegg is an Hematology/Oncology Infusion Nurse at the N.C. Cancer Hospital. In her life outside the hospital, Stacey is a vocalist with a 7 woman a cappella group called "Stella."
Dr. Lisa Carey, MD, medical director of the UNC Breast Center and associate director for clinical science at UNC Lineberger Comprehensive Cancer Center, spoke to MedPage Today about a recent Centers for Disease Control study that reported that black patients had a 41 percent higher mortality than their white counterparts, despite having a lower incidence of the disease.
The protein Ras plays an important role in cellular growth control. Researchers have focused on the protein because mutations in its gene are found in more than 30 percent of all cancers, making it the most prevalent human oncogene.
Chapel Hill, NC – In a paper published in the Nov. 21 issue of Cell, a team led by Mauro Calabrese, a postdoctoral fellow at the University of North Carolina in the lab of Terry Magnuson, chair of the department of genetics and member of the UNC Lineberger Comprehensive Cancer Center, broadens the understanding of how cells regulate silencing of the X chromosome in a process known as X-inactivation.
Neil Hayes, MD, MPH, talks to North Carolina Now about new research into lung cancer. The interview aired on the show's Nov. 12, 2012 broadcast.
Chapel Hill, NC – Ethan Basch, MD, has joined the Lineberger Comprehensive Cancer Center at the University of North Carolina School of Medicine. Basch will be an associate professor of medicine and director of the cancer outcomes research program.
Two UNC Board of Trustees members and longtime UNC Lineberger supporters were among the seven honored with the William Richardson Davie Award. The Davie Awards are the highest honor bestowed by the UNC Board of Trustees.
The 2012 Comprehensive Cancer Support Program Support Week was a huge success. Hundreds of patients and caregivers learned about and participated in activities highlighting the many support services of the Comprehensive Support Program during CCSP Support Week 2012.
UNC Lineberger Comprehensive Cancer Center and UNC Cancer Care honored four employees with 2012 Excellence Awards.
Andrew F. Olshan, PhD, has been appointed Associate Director of Population Sciences at UNC Lineberger Comprehensive Cancer Center. This senior leadership position is responsible for overseeing the development of population-based cancer research and its integration throughout the Cancer Center programs. The position also oversees several Cancer Center core resources as well as two established scientific programs, Cancer Epidemiology and Cancer Prevention and Control. Dr. Olshan will continue to serve as head of the Cancer Epidemiology Program and directs two cores, the Biospecimens Processing Facility and Rapid Case Ascertainment Core.
Valerie King is living the teenage dream, she's in the running for homecoming queen. While it's tough competition for the crown, it's nothing compared to the battle she's been fighting for the past year.
Shelley Golden, MPH, and Jo Anne Earp, ScD, co-wrote an article that received the Lawrence W. Green Paper of the Year Award at the 63rd annual meeting of the Society for Public Health Education (SOPHE), held Oct. 25-27 in San Francisco.