Rui Yu, PhD, the Leon and Bertha Golberg Postdoctoral Fellow at UNC Gillings School of Global Public Health, has been awarded a two-year, $160,000 grant from the Fanconi Anemia Research Fund. Yu’s study, “Identifying the nature of the endogenous aldehydes-induced DNA damage that Fanconi anemia DNA repair pathways counteract,” is being conducted in the laboratory of James Swenberg, DVM, PhD, Kenan Distinguished Professor of environmental sciences and engineering at the Gillings School of Global Public Health.
Fanconi anemia is an inherited disease that can lead to bone marrow failure and cancer.
“We intend with this project to identify and promote our understanding of the specific type(s) of endogenous aldehyde-induced DNA damage that the intact Fanconi anemia DNA repair pathways counteract,” Yu said. “Such results will promote our understanding of the mechanism of bone marrow failure and leukemia caused by DNA damage and will lead to future identification of novel therapies and new drugs for managing these diseases.”
Yu earned a Bachelor of Science in pharmaceutics in 2006 from China Pharmaceutical University in Nanjing and a doctorate in pharmaceutical chemistry and pharmacognosy at the University of Illinois at Chicago’s College of Pharmacy in 2012. He joined Swenberg’s lab that year as a postdoctoral research fellow.