Pathology & Lab Medicine
Area of interest
My long-term research goal is to understand mechanisms by which mammalian cells maintain ordered control of DNA replication during normal passage through an unperturbed cell cycle, and in response to genotoxins (DNA-damaging agents). DNA synthesis is a fundamental process for normal growth and development. Accurate replication of DNA is crucial for maintenance of genomic stability. Many cancers display defects in regulation of DNA synthesis. Therefore it is important to understand the molecular basis for aberrant DNA replication in tumors. Moreover, since many chemotherapeutics specifically target cells in S-phase, a more detailed understanding of DNA replication could allow the rational design of novel cancer therapeutics. My lab focuses on three main aspects of DNA replication control: I. The S-phase checkpoint, II. Trans-Lesion Synthesis (TLS) and III. Re-replication.
Awards and Honors
1996 American Cancer Society Senior Post-doctoral Fellowship
1997 American Cancer Society New Investigator Award
1997 American Cancer Society Institutional Junior Investigator Award