Cancer Cell Biology
Area of interest
Cell Cycle Control in Human Cells
Our lab studies the regulation of the mammalian cell cycle with the long-term goal of deeply understanding the dynamics of molecular events in this fundamental biological process. Cells coordinate progression through the cell division cycle with a wide variety of extracellular and intracellular information by regulating the activity and abundance of key cell cycle proteins. Many proteins have more than one function in the cell cycle, and one of our goals is to understand how those different functions are integrated to ensure normal cell proliferation and genome stability.
Among our particular emphases are exploring the cell cycle phase transitions related to DNA replication and to cell cycle exit. We manipulate cell cycle proteins in human cell lines using a variety of molecular genetic tools. We deplete proteins from cells using siRNA techniques, overproduce proteins using recombinant plasmid or viral vectors, and inhibit activities with pharmacological reagents. Collaborative projects employ live cell imaging and quantitative single cell analysis of protein abundance during the cell cycle. Ultimately we hope to achieve a greater understanding of normal cell cycle control, so that future tools for cancer diagnosis and therapy can be developed.
Awards and Honors
Recipient of the Jefferson-Pilot Fellowship in Academic Medicine
Find publications on PubMed