Qisheng Zhang

Ph.D., School of Pharmacy, UNC-Chapel Hill, Molecular Therapeutics

Qisheng Zhang

Ph.D.
School of Pharmacy
UNC-Chapel Hill
Molecular Therapeutics
2020 Genetic Medicine Building
966-9687

Related Website
CV or Biosketch

Area of interest

Lipid signaling in development and diseases

Our lab studies lipid signaling pathways that are involved in development and diseases by developing novel chemical probes and technologies. As key components of cellular membranes, lipids also serve as signaling molecules and modify functions of proteins through either covalent or non-covalent interactions. Dys-regulation of lipid signaling has been correlated with various diseases including cancer, diabetes, and neurodegenerative diseases. Consequently, many lipid-related proteins or processes have been used as therapeutic targets. However, lipids are dynamically metabolized and transported, making it difficult to illustrate the roles of lipids in development and diseases with limited availability of probes and technologies for lipid studies. The active projects in the lab include: 1) develop novel technologies to synthesize complex lipids, particularly phosphatidylinositides, and identify their interacting proteins in live cells; 2) develop new small molecule sensors and inhibitors for lipid metabolic enzymes such as PI3K and PLC; and 3) investigate cellular functions of lipids on different processes, particularly those regulated by small GTPases.

Link to Publications on Reach NC site

Find publications on Pubmed

Filed under: