School of Medicine
Area of interest
I am interested in the development and application of new imaging techniques to answer clinically relevant questions in both human and pre-clinical studies. In particular, I am interested in guiding advanced imaging techniques from pre-clinical applications into the clinic, focusing on cancer. My hope is to develop new methods to enhance our biomedical understanding and diagnostic capability of these diseases.
I have two major areas of research focused on cancer imaging and treatment.
First, I am responsible for the pre-clinical and clinical translation of the carbon nanotube (CNT) x-ray sources invented at UNC Chapel Hill by Drs. Otto Zhou and Jianping Lu. I am responsible for the human imaging applications in breast, chest and neurological imaging, and our clinical trials related to these devices. I also developed the small animal imaging approaches with the CNT x-rays, including micro-CT and the dynamic imaging techniques. Furthermore, I am actively involved with our micro-beam radiotherapy projects based on the CNT sources.
Second, I am interested in developing new advanced imaging for primary brain tumor and brain metastases using a combination of novel PET approaches and advanced MRI techniques. Specifically, I am interested in novel imaging PET imaging agents, and the development of blood-brain barrier permeability imaging for the prediction of tumor response and drug delivery. I use an integrated approach to develop techniques that may directly translate from mice to men.
I have had the fortune of working with nearly every major imaging modality, including x-ray and MRI (as above) ultrasound, ultrasound contrast agents, nuclear medicine, and electrical imaging. This offers me a unique perspective in performing translational imaging research, since I can draw on the strengths and weaknesses from every modality to answer relevant clinical questions.
Awards and Honors
2001 International Society of Magnetic Resonance in Medicine Educational Stipend Award
2001 Annual Radiology Research Symposium Award - UNC Chapel Hill
2002 International Society of Magnetic Resonance in Medicine Educational Stipend Award
2002 Annual Radiology Research Symposium Award - UNC Chapel Hill
2002 Biomedical Engineering Award – Best Presentation UNC Chapel Hill
2003 Radiological Society of North America Physics Trainee Prize
2004 Academy of Molecular Imaging Top Young Investigator Abstract
2004 International Society of Magnetic Resonance in Medicine Educational Stipend Award
2004 Annual Radiology Research Award - Best Basic Sciences Presentation UNC Chapel Hill
2008 Annual Radiology Research Symposium Award - UNC Chapel Hill
2009 Annual Radiology Research Symposium Award - UNC Chapel Hill
2010 RSNA Roentgen Resident/Fellow Research Award
2012 Lineberger Clinical Fellows Award