42nd Annual UNC Lineberger Scientific Symposium

UNC Lineberger Comprehensive Cancer Center will host its 42nd annual scientific symposium on April 2-3, 2018, at the William and Ida Friday Center for Continuing Education in Chapel Hill, NC. The meeting's theme will be "Genome Instability in Cancer: Mechanisms and Therapeutic Opportunities."

"Genome Instability in Cancer: Mechanisms and Therapeutic Opportunities"

April 2-3, 2018

The William and Ida Friday Center for Continuing Education, Chapel Hill, NC

***NOTE: While online registration is now closed, you may register for the symposium onsite at the Friday Center.***

Organizers

Albert S. Baldwin, PhD, Gaorav Gupta, MD, PhD, Dale A. Ramsden, PhD

Agenda

Monday, April 2

TimeSpeakerTitle
8:50-9:00 a.m.

Shelton Earp, MD
UNC Lineberger Comprehensive Cancer Center

Opening remarks
9:00-9:35 a.m. Luis A. Diaz, Jr., MD
Memorial Sloan Kettering Cancer Center

Novel clinical applications of cancer genomics

9:35-10:10 a.m. Roger Greenberg, MD, PhD
Abramson Family Cancer Research Institute, The Perelman School of Medicine, University of Pennsylvania
How DNA double-strand breaks activate anti-tumor immune responses
10:10-10:35 a.m.

Gaorav Gupta, MD, PhD
UNC Lineberger Comprehensive Cancer Center

Genetic determinants of cellular addiction to polymerase theta
10:35-11:05 a.m. Break
11:05-11:45 a.m. Tom Kunkel, PhD
NIEHS

The roles of B family DNA polymerases in eukaryotic DNA replication

11:35 a.m. -12:00 p.m. Sue Jinks-Robertson, PhD
Duke University

Transcription and DNA stability: there’s trouble in the bubble

12:00-1:00 p.m. Lunch
1:00-1:35 p.m.

John Petrini, PhD
Chairman, Molecular Biology Program, Memorial Sloan Kettering Cancer Center

Genetic analysis of chromosome break metabolism
1:35-2:10 p.m.

Tanya Paull, PhD
Howard Hughes Medical Institute, University of Texas at Austin

Mechanisms of DNA double-strand repair
2:10-2:35 p.m.

Jeff Sekelsky, PhD,
UNC Lineberger Comprehensive Cancer Center

Double-strand break repair by synthesis-dependent strand annealing
2:35-3:05 p.m. Break
3:05-3:40 p.m.

Junjie Chen, PhD
Professor and Chair, Department of Experimental Radiation Oncology, The University of Texas, MD Anderson Cancer Center

Proteomic analysis of DNA damage response and tumorigenesis
3:40-4:05 p.m.

Scott Williams, PhD
Senior Investigator and Deputy Chief, Genome Integrity and Structural Biology Laboratory, NIEHS

Topoisomerase 2 DNA-protein crosslink reversal
4:05-4:30 p.m.

Cyrus Vaziri, PhD
UNC Lineberger Comprehensive Cancer Center

Pathological Trans-Lesion Synthesis – A mutagenic driver and molecular vulnerability in cancer

Tuesday, April 3

TimeSpeakerTitle
9:00-9:35 a.m.

Elise Kohn, MD
Head, Gynecological Cancer Therapeutics, National Cancer Institute

Clinically targeting DNA repair--alone and in combinations
9:35-10:10 a.m.

Alan D’Andrea, MD
Director, Susan F. Smith Center for Women’s Cancer, The Fuller-American Cancer Society Professor, Dana-Farber Cancer Institute, Harvard Medical School

Novel Mechanisms of PARP Inhibitor Resistance
10:10-10:35 a.m. Michael Kastan, MD, PhD
Director, Duke University Cancer Center

An ‘Alternative’ Approach to p53 Regulation

10:35-11:05 a.m. Break
11:05-11:40 a.m.

Jan Karlseder, PhD
Donald and Darlen Shiley Chair, Professor, Director, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, Salk Institute

Regulation of repair pathway choice by CYREN

11:40 a.m. -12:05 p.m.

Dorothy Erie, PhD
UNC Lineberger Comprehensive Cancer Center

Combining single molecule approaches to investigate the initiation of DNA mismatch repair

12:05-12:30 p.m.

Dale Ramsden, PhD
Director of Graduate studies and the MiBio Training Program, UNC Lineberger Comprehensive Cancer Center

Incorporation of RNA during DNA repair
Closing remarks
12:30 p.m. Lunch