Recent News

Researchers unlock mechanism of drug resistance in aggressive breast cancer

Researchers unlock mechanism of drug resistance in aggressive breast cancer

In the journal Cancer Discovery, UNC Lineberger researchers Gary Johnson, PhD, and Lisa Carey, MD, and colleagues report findings of just how triple negative breast cancer cells are able to bypass treatment with trametinib, a U.S. Food and Drug Administration-approved drug that belongs to a class of commonly used anti-cancer drugs called kinase inhibitors. The researchers also reported findings from laboratory models of breast cancer testing a potential treatment approach that could prevent the onset of resistance.

Researchers unlock mechanism of drug resistance in aggressive breast cancer - Read More…

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse

A team of researchers, including UNC Lineberger's Norman E. Sharpless, MD, has shown that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. Eliminating the senescent cells in mice prevented the side effects and relapse.

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse - Read More…

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer

Backed by a three-year, more than $1.8 million grant from the National Cancer Institute, UNC Lineberger researchers Ryan Miller, MD, PhD, and Gary Johnson, PhD, plan to develop better cancer models to identify patterns of drug resistance in glioblastoma.

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer - Read More…

 Cost, technology issues are barriers to real-time cancer patient symptom reporting

Cost, technology issues are barriers to real-time cancer patient symptom reporting

In a perspective published in the New England Journal of Medicine, UNC Lineberger member Ethan Basch, MD, MSc, addressed the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits.

Cost, technology issues are barriers to real-time cancer patient symptom reporting - Read More…