CHAPEL HILL, N.C. – Research findings from the University of North Carolina School of Medicine are shining a light on an important regulatory role performed by the so-called dark matter, or “junk DNA,” within each of our genes.
This month's focus is on the ever-popular mode of entertainment enjoyed throughout the centuries: the theater. Keith Burridge, a Kenan Professor of Cell Biology and Physiology, is also a playwright. His most recent play, The Art of Deception, is based on a true story of a dutch painter, Han van Meegeren.
Jenny Ting, PhD, Alumni Distinguished Professor in UNC’s Department of Microbiology and Immunology and member of UNC Lineberger, has been awarded the American Association of Immunologist’s Life Technologies Meritorious Career Award for 2013.
The best approach to detecting cervical cancer in HIV-positive women living in research limited countries such as those in Sub-Saharan Africa combines commonly used testing methods tailored to local levels of development and medical infrastructure, according to a study by researchers from and the University of Witwatersrand in South Africa and the University of North Carolina.
A 2009 survey by UNC faculty of North Carolina middle and high schoolers found that 79 percent support smoke-free areas and other smoking bans.
Joseph DeSimone, PhD, was awarded the 2012 Watson Chubb Award for Innovation from the Sigma Xi, The Scientific Research Society. The award honors creativity among scientists and engineers.
Dr. Qi Zhang receives the 2013 Basil O’Connor Starter Scholar Research Award from the March of Dimes Foundation.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, spoke to National Public Radio's All Things Considered about the need to find a balance between making genetic data available to researchers and protecting patient privacy.
Norman Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Deputy Cancer Center Director, discussed the development of a mouse model to study aging and cancer with WUNC's Frank Stasio.
The 2012 University Cancer Research Fund Innovation Awards recognize six University of North Carolina researchers for groundbreaking cancer research. The UCRF Innovation Awards are designed to support innovation, collaboration and cancer-focused science across a broad spectrum of the cancer-research community at UNC.
The Scientist Magazine has featured recent research by Timothy Gershon, MD, PhD, on the link between brain tumors and glycolysis.
A University of North Carolina School of Medicine study may have implications for thwarting the effects of bioterrorism attack with lethal microbes, as well as finding a way to save people in septic shock, an overwhelming bacterial infection of the blood.
The Triad Golfers Against Cancer has awarded two grants to researchers at the UNC Lineberger Comprehensive Cancer Center totaling $65,000.
A new study from the University of North Carolina published January 25, 2013 in the journal Genome Medicine reveals the huge diversity of U.S. biobanks and also raises questions about the best way to manage and govern them
UNC researchers find a way to unlock the secrets of DNA’s dark matter.
Worldwide, many strains of the bacterium Staphyloccocus aureus are already resistant to all antibiotics except vancomycin. But as bacteria are becoming resistant to this once powerful antidote, S. aureus has moved one step closer to becoming an unstoppable killer. Now, researchers at the University of North Carolina at Chapel Hill have not only identified the mechanism by which vancomycin resistance spreads from one bacterium to the next, but also have suggested ways to potentially stop the transfer.
More than 150 physicians and patients gathered February 6th and 7th to learn more about melanoma. Melanoma Patient Day, February 6, was a half-day symposium sponsored by the Melanoma Research Foundation, the UNC Division of Surgical Oncology and the UNC Department of Dermatology. Meeting co-chairs were Drs. David Ollila, professor of surgery, and Nancy Thomas, Robert Alan and Irene Briggaman Distinguished Professor of Dermatology.
In a study published in the January 18 issue of Cell, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have developed a new method to visualize aging and tumor growth in mice using a gene closely linked to these processes.
What’s most important to a man as he decides whether or not to undergo prostate-specific antigen- PSA- screening for prostate cancer? What does he value most about the screening? And what’s the best way to present the information to help him make an appropriate decision for himself?
Ethan Basch, MD, MSc, Director of Cancer Outcomes Research at the UNC Lineberger Comprehensive Cancer Center, has been appointed by the Director of the National Cancer Institute to serve on the Board of Scientific Advisors (BSA).
Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) hide within the worldwide human population. While dormant in the vast majority of those infected, these active herpesviruses can develop into several forms of cancer. In an effort to understand and eventually develop treatments for these viruses, researchers at the University of North Carolina have identified a family of human genes known as Tousled-like kinases (TLKs) that play a key role in the suppression and activation of these viruses.
Leah Ranney, PhD, associate director of the UNC Tobacco Prevention and Evaluation Program, and Adam Goldstein, MD, professor in UNC Family Medicine and director of the Tobacco Prevention and Evaluation Program, published the following editorial on the social benefits of anti-smoking policies and tobacco-use prevention programs:
North Carolina’s community colleges are important settings for educating and training our citizens. Can they also play a role in preventing cancer? A group of UNC researchers recently looked into the question of whether community colleges could spread the latest evidence-based cancer and wellness information to the thousands of employees and students of the state’s community college system.
The Triangle Business Journal has named two UNC Lineberger members as finalists for the 2013 Health Care Heroes Awards.
A set of towlettes developed by two researchers at Carolina can safely remove difficult-to-clean anticancer drugs commonly found on surfaces in hospitals, pharmacies, clinics and labs. The product, called Hazardous Drug Clean – or HDClean – addresses the growing concern regarding the safety of health care workers who frequently handle these potentially dangerous drugs.
Preclinical study shows potential of new technologies to detect response to cancer therapy earlier
Michael Pignone will join fellow experts in evidence-based medicine from many health-related fields to rigorously review existing peer-reviewed evidence and evaluating the benefits and harms of preventive services.
The article profiles Russell Tatum, a father who found emotional support for himself and his family through the UNC Lineberger-supported group designed for fathers who have lost a spouse to cancer.
Inflammatory response plays a major role in both health protection and disease generation. While the symptoms of disease-related inflammatory response have been know, scientists have not understood the mechanisms that underlie it.
The publication names the cancer center as one of the top 100 oncology programs in the nation.
Triple-negative breast cancers are more biologically diverse than previously believed and classification should be expanded to reflect this heterogeneity, according to University of North Carolina researchers.
More than 70 kidney cancer patients and their families participated in the Kidney Cancer Association’s patient and survivor conference held at the Friday Continuing Education Center in Chapel Hill on February 23.
James Evans, Bryson Distinguished Professor of Genetics and Medicine, was interviewed about his work as principal investigator on the NCGENES Study with WCOM 103.5's Radio In Vivo.
Head and neck squamous cell carcinoma (HNSCC) is the seventh most common form of cancer in the United States, but other than an association with the human papillomavirus, no validated molecular profile of the disease has been established. By analyzing data from DNA microarrays, a UNC-led team has completed a study that confirms the presence of four molecular classes of the disease and extends previous results by suggesting that there may be an underlying connection between the molecular classes and observed genomic events, some of which affect known cancer genes. The clinical relevance of the classes and certain genomic events was demonstrated, thus paving the way for further studies and possible targeted therapies.
Could glowing rodents come to the aid of cancer researchers … and patients?
A UNC Lineberger-affiliated program that provides HIV and cervical cancer testing in Malawi and Zambia was featured on the Raleigh-Durham ABC affiliate.
Experts from the UNC School of Medicine and the UNC Gillings School of Global Public Health propose that screening healthy adults for preventable diseases such as colorectal cancer, breast cancer, and several catastrophic blood vessel disorders, among others, could potentially prevent these diseases.
New chemical probe provides tool to investigate role of malignant brain tumor domains in chromatin structure and regulation
In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC Eshelman School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain. The probe, named UNC1215, will provide researchers with a powerful tool to investigate the function of malignant brain tumor (MBT) domain proteins in biology and disease.
Researchers at the University of North Carolina at Chapel Hill have discovered how helper molecules, or chaperones, aid in the RNA folding process, resolving a fundamental conundrum about how these important biological molecules work.
The journal Oncology's online Cancer Network profiled an address given by Hyman Muss, MD, professor of medicine, at the 30th Annual Miami Breast Cancer Conference in March.
To meet a growing need for nurses with advanced training, the University of North Carolina and five other UNC-system schools will offer a doctorate in nursing this fall. The News and Observer article discusses the need and role that will be filled by the new Doctors of Nursing Practice.
The School ranked 1st in Primary Care and 22nd in Research overall in the 2014 U.S. News & World Report Best Medical School Rankings. Family Medicine, Rural Medicine and AIDS were also listed as top ten specialties.
A study by Karyn Stitzenberg, MD, MPH, assistant professor of surgery and member of the UNC Lineberger Comprehensive Cancer Center, shows that surgical oncologists comprise only a small portion of the number of surgeons who perform cancer surgery.
Two members of the UNC Lineberger Comprehensive Cancer Center have been elected as 2013 Fellows of the American Academy of Microbiology (AAM), the honorific leadership group within the American Society for Microbiology (ASM).
For the first time, a population-based study of a human papillomavirus (HPV) vaccine has proven that the vaccine is effective in reducing the incidence of genital warts.
Michael Pignone, MD, MPH, Professor of Medicine and Division Chief of General Medicine and Epidemiology, has been named director of the UNC Institute for Health Care Quality Improvement, which aims to establish UNC as the leading academic medical center in the area of clinical quality improvement. The new institute is a product of the UNC School of Medicine’s Strategic Plan.
Jenny Ting, PhD, W.R. Kenan, Jr. Distinguished Professor of Microbiology and Immunology, has been awarded a 2013 University Award for the Advancement of Women.
Debbie Dibbert, Director of External Affairs at UNC Lineberger, was named as a Hometown Hero by WCHL 97.9 and Chapelboro.com.
Ribisl predicts that new regulations preventing the open display of cigarettes in stores could lead to a reduction in smoking over time.
Lymphedema therapist Theresa Gilliam assists patient Judy Reaves with a sleeve designed to ease her symptoms.
Using pharmacological inhibitors and gene-silencing approaches, Otey and the research team discovered that disrupting palladin in CAFs reduced the ability of the cells to form invadopodia.
Researchers at the University of North Carolina at Chapel Hill have discovered that a protein found in the cells surrounding pancreatic cancers play a role in the spread of the disease to other parts of the body.
“It’s a lifesaver.” That’s how Frances Patterson, a breast cancer patient, describes the therapy she receives for lymphedema through the UNC Comprehensive Cancer Support Program.
Oliver Smithies did not set out to become one of the world’s foremost pioneers in cancer research. He merely had a question that needed answering.
Barbara Fredrickson, professor of psychology and UNC Lineberger member, writes in an editorial in the New York Times that the physical and psychological tools that allow us to relate to others can diminish with lack of use.
James Evans, director of UNC's Clinical Cancer Genetics program and UNC Lineberger member, says it is time for a public health strategy that focuses on genetic testing of healthy adults.
Craven County resident, Cindy Sills, has alveolar rhabdomyosarcoma, a cancerous tumor of the muscles that are attached to bones. She and her husband work to raise awareness of rare rare soft-tissue cancer.
Research conducted in fruit flies at the University of North Carolina School of Medicine has pinpointed a specific DNA sequence that both triggers the formation of the “histone locus body” and turns on all the histone genes in the entire block.
NBC's Today Show spotlighted the first-of-its-kind program designed to help single dad's who have lost a spouse to cancer. NBC’s Dr. Nancy Snyderman reports on the group's efforts.
Men who have dependent children and whose spouses or partners died from cancer are an overlooked population. These fathers face unique challenges not addressed by traditional grief support groups that often attract an older, female population.
Cancer patients at UNC and Duke have one less thing to worry about, thanks to the recently launched Cancer Pro Bono Legal Project. This cutting-edge collaboration among the law schools and cancer centers at the two universities and the North Carolina Bar Association offers free legal services to local cancer patients. The project has won funding from the Kenan Biddle Foundation as well as the North Carolina Bar Foundation.
African American men on average wait a week longer than their Caucasian counterparts between the initial diagnosis of prostate cancer and treatment, according to University of North Carolina researchers.
Hyman B. Muss, MD, Professor of Medicine, Director of Geriatric Oncology, Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill School of Medicine, discusses the need for a team environment when treating an older patient at OncLive.
It’s given my daughter power of attorney over me. It’s convenient for me to get it done when I’m coming to clinic. It gives my daughter the authority so I don’t have to worry about it if something happens to me.
Law student Jason Jones works with Dat Nguyen of Chapel Hill.
The accomplishment provides a much-needed resource for scientists eager to uncover the true mechanisms of human stem cell biology. It also enables them to explore new tactics to treat inflammatory bowel disease or to ameliorate the side effects of chemotherapy and radiation, which often damage the gut.
Satish Gopal, MD, MPH, assistant professor in the divisions of hematology/oncology and infectious diseases at the UNC School of Medicine, describes his experiences in assisting Kamuzu Central Hospital in the creation of a lab to diagnose and research cancer in Malawi.
Neil Hayes, MD, MPH, associate professor in UNC's Division of Hematology and Oncology, presented on the patterns of genomic alterations in head and neck squamous cell carcinomas (HNSCC) at the AACR's 2013 Annual Meeting in Washington, D.C.
Lisa A. Carey, MD, Medical Director of the UNC Breast Center, the Chief of Hematology/Oncology, the Physician-in-Chief of the N.C. Cancer Hospital, and UNC Lineberger member, discusses the use of everolimus in the metastatic and adjuvant settings of breast cancer.
A team led by Dr. Stanley Lemon discovered that hepatitis A virus does not have an envelope when found in the environment, but acquires one from the cells that it grows in within the liver. It circulates in the blood completely cloaked in these membranes.
Researchers at the University of North Carolina at Chapel Hill School of Medicine have "rationally rewired" some of the cell's smallest components to create proteins that can be switched on or off by command. These "protein switches" can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease.
James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted about a case before the U.S. Supreme Court involving Myriad Genetics attempts to patent two human genes related to breast and ovarian cancer.
A Dare County real estate agent refuses to let a breast cancer diagnosis and its treatment detract from her trademark sense of humor and constant outreach to others.
Transcription factors regulating blood oxygen linked to melanoma metastases
Kerry Steven Bloom, Thad L. Beyle Distinguished Professor of biology at the University of North Carolina at Chapel Hill, has been elected to the American Academy of Arts and Sciences, one of the nation’s oldest and most prestigious honorary societies and a leading center for independent policy research.
A team from the UNC Bone Marrow and Stem Cell Transplant Program headed up by Tippu Khan, PharmD, BCOP and Nicole Frazier, RN, BSN participated in an epic journey which included leaping over fire, trekking through waste-high mud, tossing spears, dodging attacks and most of all braving near freezing temperatures in the driving rain. What is all this about? It's the Spartan Race, an event of pure primitive craziness that promises it's participants an experience they'll never forget.
Dr. Harold E. Varmus, director of the National Cancer Institute at the National Institutes of Health and co-winner of the 1989 Nobel Prize in Physiology or Medicine for the discovery of the cellular origin of retroviral oncogenes, was invited to campus by UNC’s Nobel Laureate Dr. Oliver Smithies.
Sethi, MacNevin, Feng come out on top at 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum
On Friday, April 19, from 2 p.m. to 4 p.m. in the MBRB at the School of Medicine, 44 university postdoctoral fellows gathered for a poster forum to present their research findings.
A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.
Kurt Ribisl, PhD, head of Cancer Prevention and Control Program at the UNC Lineberger Comprehensive Cancer Center, was interviewed by National Public Radio on New York City's proposal to raise the legal age to buy cigarettes to 21.
Associate professor Deborah Mayer, PhD, RN, AOCN, FAAN and member of UNC Lineberger has been selected as an Extraordinary Nurse Leader by Yale University, the first independent university-based nursing school established in the United States. As part of its 90th anniversary celebration, Yale School of Nursing has selected 90 alumni who “embody the School’s mission of advancing better health care” to be honored at a ceremony in October 2013.
Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease. An international team, led by scientists at the University of North Carolina Lineberger Comprehensive Cancer Center, reports pre-clinical research showing improved efficacy of a PEGylated liposomal (encapsulated) anti-cancer agent compared with a non-liposomal formulation of the same drug in an intracranial model of breast cancer. Their results were published in the May 1, 2013 issue of PLOS ONE.
Close to 450 people attended the 37th annual UNC Lineberger scientific symposium April 29 and 30, 2013. Symposium co-chairs were Jonathan Serody, MD, PhD, Elizabeth Thomas Chair of Medicine, and Jenny Ting, PhD, UNC Alumni Distinguished Professor of Microbiology and Immunology. Both spoke at the symposium.
Raj Pruthi, MD, Chief of Urologic Surgery for the Urologic Oncology Program spoke at the annual meeting of the American Urological Association (AUA) in San Diego, California.
Health reporter for the New York Times, Jane Brody, features the Single Fathers Due to Cancer program.
UNC Lineberger was well represented at the American Association for Cancer Research Annual Meeting held in Washington, DC.
In Kenya, women face a cervical cancer mortality rate that is approximately 10 times as high as in the United States. A study by researchers at the University of North Carolina at Chapel Hill suggests that training women to self-collect genital samples to test for human papillomavirus (HPV), the causative agent of cervical cancer, can increase the coverage rates of cervical cancer screening. Higher screening coverage helps increase rates of detection of cervical lesions and ultimately treatment of the disease.
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
Hy Muss, MD, Director, Geriatric Oncology Program discusses evaluation tools for treating older patients on OncLive.
Patients must take a larger role in participating in and assisting in determining priorities for medical research, according to an editorial published in an upcoming issue of the Journal of the American Medical Association.
Jennifer Smith, PhD, MPH, research associate professor at the UNC Gillings School of Global Public Health and member of the UNC Lineberger Comprehensive Cancer Center, says that lack of awareness and stigma about the illness hinders prevention of the disease.
Q&A with UNC Lineberger members James P. Evans, MD, PhD; David Ollila, MD; Paola Gehrig, MD; and Keith D. Amos, MD, FACS.
Claire Dees, MD, and Neil Hayes, MD, MPH, have been appointed as co-leaders of the Clinical Research Program at UNC Lineberger Comprehensive Cancer Center. Dr. Dees and Hayes have extensive and complementary expertise in translational and clinical research. As co-leaders of the Clinical Research Program, they will help plan the efforts of UNC Lineberger’s physician researchers to move discoveries into innovative trials of new therapeutic approaches.
Barbara K. Rimer, DrPH, Dean and Alumni Distinguished Professor of the University of North Carolina Gillings School of Global Public Health, has been awarded the American Cancer Society (ACS) Medal of Honor for her "seminal cancer research efforts."
Endeavors profiles the work of Nancy Klauber-DeMore, MD, professor of surgery and a member of UNC Lineberger, in unraveling the mystery of whether the gene SFRP2 suppresses tumor growth.
University of North Carolina School of Medicine researchers uncover surprising insights about how nerve cells rewire themselves, shedding light on a process linked with neurodegenerative diseases and neurodevelopmental disorders like schizophrenia and autism.
Neurons can be cultured in one compartment of a microfluidic chamber (right side) and extend their axons through very small grooves into a separate compartment (left side).
Charles Perou, PhD, the May Goldman Shaw Distinguished Professor of Molecular Oncology, has been honored with the 2013 Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research. Dr. Perou is a member of UNC Lineberger Comprehensive Cancer Center.