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UNC Lineberger researchers help map the cancer genome, generate key insights
UNC Lineberger researchers led two major projects to mark the finale of The Cancer Genome Atlas project, which was backed by the National Cancer Institute and National Human Genome Research Institute.
Located in News
UNC researchers create DNA repair map of the entire human genome
The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
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Researchers discover how faulty genetic instructions drive a deadly blood cancer in adults
A study by UNC Lineberger researcher G. Greg Wang, PhD, and colleagues uncovered the genetic mechanism behind how acute myeloid leukemia cells with a specific DNA mutation stay as undifferentiated cells, rather than maturing into healthy blood cells.
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Perou recognized as health care innovator, awarded Triangle Business Journal honor
Charles M. Perou, PhD, professor of genetics and pathology at the University of North Carolina School of Medicine and the basic science leader of the UNC Lineberger Comprehensive Cancer Center Breast Cancer Research Program, has been acknowledged as a health care innovator by the Triangle Business Journal. During an awards ceremony on Thursday, Perou was selected from a pool of candidates as the finalist in the 2015 TBJ Health Care Heroes – Innovator category.
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Leading immune system discovery at the molecular level
Jenny Ting, PhD, a UNC Lineberger Comprehensive Cancer Center member and a William R. Kenan Jr. Distinguished Professor in the UNC School of Medicine Department of Genetics, has studied genetic and molecular mechanisms behind immune system development for more than three decades at UNC. Now she’s helping to lead two major federal center grants to further vaccine development and boost our understanding of immune responses to viruses.
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Blood cancer treatment may age immune cells as much as 30 years
Researchers led by UNC Lineberger Director Norman Sharpless, MD, and William Wood, MD, uncovered clues that suggest that stem cell transplant is linked to a marked increase in the “molecular age” of these immune cells in a group of patients with blood cancer.
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Researchers find new approach to treat drug-resistant HER2-positive breast cancer
Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.
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A new era for genetic interpretation
UNC Lineberger researchers are collaborating through the ClinGen consortium - a program launched to evaluate the clinical relevance of genetic variants - to help physicians make predictions about an individual’s risk of disease, develop more accurate clinical trials and design individualized treatments and care for patients.
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UNC Lineberger researchers identify genetic ‘seeds’ of metastatic breast cancer
In the Journal of Clinical Investigation, UNC Lineberger researchers Lisa A. Carey, MD, Charles M. Perou, PhD, and Carey Anders, MD, Marni Siegel and colleagues published their analysis of the genetic differences they discovered in patients’ primary breast cancers and their metastatic cancers.
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Precision medicine at UNC: Looking for cancer-driving gene mutations across cancers
UNC Lineberger will be enrolling patients into a new, national clinical trial, known as NCI-MATCH, that will group patients based on the genetics of their tumors as opposed to where their cancer is located. The new initiative will test more than 20 drugs or drug combinations targeting specific genetic mutations.
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