Skip to main content

Andrew Lee, PhD, is a UNC Lineberger Comprehensive Cancer Center member with research interests in protein dynamics, allosteric function, structural biology and NMR spectroscopy.

Professor, Division of Chemical Biology and Medicinal Chemistry
UNC-Chapel Hill
Molecular Therapeutics

Area of Interest

Protein dynamics, allosteric function, structural biology, NMR spectroscopy

Nearly all biological processes are driven by the same fundamental event: protein conformational changes. The mechanics that govern how proteins “morph” their three-dimensional structures into alternative conformations need to be understood in order to understand the biochemical basis of protein function. Our research is aimed at atomic resolution characterizations of the structural and dynamic properties of proteins and their interactions with other proteins, ligands, and small molecule drugs. Towards this goal, we are making extensive use of heteronuclear NMR spectroscopy and other experimental and theoretical tools. NMR spectroscopy is ideal for our studies, as hundreds – even thousands – of structural and motional “spin probes” are uniformly distributed throughout any given protein. We have a general interest in the role of dynamics in protein function and allostery.

Awards and Honors

  • Junior Faculty IBM Fund Award, 2006
  • American Association of Colleges of Pharmacy (AACP) New Investigators Program (NIP) Award for Pharmacy Faculty: UNC-Chapel Hill, 2001-2002

Find publications on PubMed

Headshot of Andrew Lee
  • Phone Number

    (919) 966-7821 (Office Phone)

  • Address

    4109 Marsico Hall

    125 Mason Farm Rd.

    CB #7363

    Chapel Hill, NC 27599-7363