Antonio L. Amelio

PhD, Assistant Professor, UNC-Chapel Hill, Oral and Craniofacial Health Sciences

PhD
Assistant Professor
UNC-Chapel Hill
Cancer Cell Biology

Area of interest

Our laboratory is broadly interested in understanding the molecular mechanisms of transcriptional regulation by cell signaling pathways and the role of pathway cross-talk in cancer biology. In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS-protein coupled receptor (GPCR)-mediated activation of PKA and long-term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs). We are applying an interdisciplinary approach to study the consequences of aberrant activation of the cAMP/CREB/CRTC signal circuit on these adaptive responses and how cooperative signaling with other pathways promotes oncogenic processes in oral, head, and neck cancers. The information gathered from these studies is being directed towards drug discovery efforts.

We employ a wide variety of state-of-the-art technologies such as in vivo optical imaging and high-throughput methods including cell-based screening, genomics, and proteomics approaches. The lab recently developed novel LumiFluor® optical reporters and are now implementing these reporters for the non-invasive, high resolution in vivo optical imaging of tumor development, progression, and response to therapeutic intervention in genetically engineered mouse models (GEMM) of cancer.

Awards and Honors

  • 2019 First Place, IADR Joseph Lister Award for New Investigators
  • 2019 Invited Speaker, Annual Brigham and Women’s Invited Speaker Series, Harvard Medical School
  • 2019 Invited Speaker, Gordon Research Conference on Salivary Glands and Exocrine Biology, Galveston, TX
  • 2019 Finalist, IADR Joseph Lister Award for New Investigators
  • 2018 Finalist, AADR Joseph Lister Award for New Investigators
  • 2017 IBM and R. J. Reynolds Industries Junior Faculty Development Award (UNC-CH)
  • 2016 Finalist, NIH New Innovator Award Competition (NIH Director’s Common Fund, DP2)
  • 2012-2017 Career Development Award, NIH/NCI Howard Temin Pathway to Independence Award in Cancer Research (K99/R00)
  • 2012 Invited Speaker, NIH Workshop on Salivary Gland Tumor Research, Bethesda, MD
  • 2012-2017 Career Development Award, Howard Temin Pathway to Independence Award in Cancer Research (K99/R00), National Cancer Institute (NCI), National Institute of Health (NIH)
  • 2012 Invited Speaker, NIH Workshop on Salivary Gland Tumor Research, Bethesda, MD
  • 2011-2012 Postdoctoral Fellowship, PGA National Women’s Cancer Awareness Days Fellowship
  • 2011 Training Award, AACR Scholar-in-Training Award, 102nd AACR Annual Meeting
  • 2008-2011 Postdoctoral Fellowship, Ruth L. Kirschstein National Research Service Award Post-Doctoral Fellowship (F32), National Cancer Institute (NCI), National Institute of Health (NIH)

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