Boshamer Distinguished Professor and Vice Dean for Research
School of Medicine
Virology & Global Oncology
Area of Interest
Globally, it is estimated that between 15-20 percent of all cancers are associated with oncogenic viruses. These include EBV, KSHV, HPV, HCV, HBV, MCV and HTLV-1. The work in our laboratory is focused on understanding the molecular pathogenesis of different oncogenic viruses. We study several oncogenic human viruses including, but not limited to, Kaposi’s sarcoma-associated herpesvirus (KSHV).
KSHV is associated with a number of human malignancies including Kaposi’s sarcoma (KS) and B-cell lymphoproliferative diseases such as multicentric Castleman’s disease and non-Hodgkin lymphoma i.e. primary effusion lymphoma. Malignancies associated with KSHV are usually (but not always) seen in the context of immune-suppression i.e. in HIV-infected individuals and transplant patients. Both Epstein-Barr virus (EBV) and KSHV are gammaherpesviruses. Herpesviruses are characterized by their ability to persist in either a latent or lytic phase in the host. In latent infection, viral gene expression is limited and the viral genome remains associated with the cell for many generations without virus production. However, during the lytic phase there is a temporal order of viral gene expression resulting in the production of infectious viral progeny. The specific mechanisms as to how these viruses induce cellular transformation are under investigation and our lab is focused on understanding how the virus transforms cells and persists in them.
We also study basic cellular and viral mechanisms that determine how these viruses are able to maintain the latent and lytic phases of its lifecycle. Hence, the work in our lab spans the fields of infectious disease, cancer biology and immunology.
Please visit our lab website www.damania.org
Awards and Honors
- 2018, Faculty Award for Excellence in Doctoral Mentoring, UNC- Chapel Hill
- 2017 Fellow, American Association for the Advancement of Science (AAAS)
- Cary C. Boshamer Distinguished Professorship, UNC Chapel Hill (2015)
- 2013 Fellow, American Academy of Microbiology, USA
- 2011 Kavli Scholar, National Academy of Sciences, USA
- 2011 Dolph O. Adams Award, Society for Leukocyte Biology
- 2008 Phillip and Ruth Hettleman Prize for Scholarly and Artistic Achievement
- Burroughs Welcome Fund Investigator in Infectious Disease (2006-2011)
- American Heart Association Established Investigator Award (2006-2011)
- Jefferson Pilot Award in Faculty Medicine (2005)
- Leukemia & Lymphoma Society Scholar (2005-2010)
- AACR-Gertrude Elion Scholar Award (2004
- American Herpes Foundation Research Scholar Award (2003)
- V Foundation Scholar Award (2001)