Skip to main content

Bryan Roth, MD, PhD, is a UNC Lineberger Comprehensive Cancer Center member researching molecular neuropharmacology.

Michael Hooker Distinguished Professor
UNC-Chapel Hill
Molecular Therapeutics

Area of Interest

I have studied molecular neuropharmacology for more than 30 years. Most recently, my lab invented the DREADD (Designer Receptor Exclusively Activated by Designer Drug) technology. DREADDs represent a novel synthetic biological tool-kit which enables the non-invasive remote control of neuronal signaling via orthologous ligand-receptor pairs. Since the introduction of the DREADD approach in 2007, we have shared this technology with nearly 300 different labs around the world. My lab also pioneered a novel chemical biological platform we refer to as ‘receptorome profiling’ which allows my lab (and our many collaborators) to identify molecular targets for novel biological entities across a large number of neuronal molecular targets. Over the past 3.5 years, via the shared resources of the National Institute of Mental Health’s Psychoactive Drug Screening Program (NIMH-PDSP) we have collaborated with nearly 400 labs world-wide.

Find publications on PubMed

Awards and Honors

  • Highly Cited Researchers (Top 1%), Web of Science, Clarivate Analytics, 2020, 2021, 2022, 2023
  • PhRMA Foundation Excellence in Pharmacology Award, 2011
  • Irving Page Lecture, Serotonin Club Meeting, Montreal, 2010
  • Lowenthal Lecture, Medical College of Virginia Neurosciences Symposium, 2010
  • Plenary Lecturer Medical University of South Carolina Neurosciences Retreat, 2009
  • NARSAD Distinguished Investigator Award, 2008
  • Michael Hooker Distinguished Professor, UNC-Chapel Hill, 2007-present
  • Plenary Lecturer, Roche Pharmaceuticals Global Research, Palo Alto, 2007
  • Prestige Lecture Université de Montréal, 2007
  • SG Fergusson Memorial Lecture, Robarts Institute, 2006
  • Chauncy Leake Memorial Lecturer, Univ. Texas Medical Branch, 2005
  • Yale BSTP Distinguished Lecturer, 2005
  • NARSAD Independent Investigator, 1998-2000
  • Heffter Research Institute Award for Outstanding Basic Science Research, 1999
  • National Institute of Mental Health Career Development Award (KO2), 1996-2006
  • Sandoz Investigator, NARSAD, 1993-1994
  • NARSAD Young Investigator, 1992-1994;
  • Dana Foundation Fellowship in Neurosciences, Stanford University, 1989-1991
  • ACNP Travel Fellow 1990
  • Phi Beta Kappa, 1983
  • March of Dimes Research Fellowship, 1977

News and Stories

View all related posts