PhD
Assistant Professor, Department of Biochemistry and Biophysics
UNC-Chapel Hill
Cancer Cell Biology
Area of Interest
Receptor tyrosine kinases are clinically important family of receptors that act as key regulators of a wide range of biological functions. Our lab is broadly interested in the structural and functional principles that guide receptor tyrosine kinase signaling, including understanding how lipids contribute to receptor signaling. Traditionally, when investigating signaling pathways there has been a focus on how interactions between signaling molecules (i.e. ligands) and receptors toggle receptor between activated or inactive states, but it’s becoming increasingly clear that there is much more complexity to receptor tyrosine kinase (RTK) activation. Importantly, improving our understanding of these processes allows us to explore alternative strategies for treatment in diseases where aberrant signaling occurs. To better understand the structural basis of RTK signaling, my lab is currently focused on studying TAM (Tyro3, Axl and Mer) receptors. TAMs are a mechanistically understudied RTK subfamily whose activation appears to involve not only ligand but also interactions with the membrane lipid, phosphatidylserine. These non growth-factor associated receptors have a vital role in maintaining cellular homeostasis through the clearance of apoptotic cells and control of inflammatory and immune responses and, because of this, dysregulation of TAM receptors is implicated in numerous diseases including autoimmune diseases and cancer. How TAM receptors are activated is an important basic question that my lab aims to address through structural, biochemical, and cellular studies. Additionally, we are interested in investigating the structures of other receptors and transporters that interact with the lipid phosphatidylserine and appear to have overlapping roles with TAM receptors in diseases such as Alzheimer’s disease, to improve our basic understanding of how the lipid microenvironment may impact important cellular processes.
