Skip to main content

Professor, Pathology & Lab Medicine
UNC-Chapel Hill
Cancer Genetics

Area of Interest

My long-term research goal is to understand mechanisms by which mammalian cells maintain ordered control of DNA replication during normal passage through an unperturbed cell cycle, and in response to genotoxins (DNA-damaging agents). DNA synthesis is a fundamental process for normal growth and development. Accurate replication of DNA is crucial for maintenance of genomic stability. Many cancers display defects in regulation of DNA synthesis. Therefore it is important to understand the molecular basis for aberrant DNA replication in tumors. Moreover, since many chemotherapeutics specifically target cells in S-phase, a more detailed understanding of DNA replication could allow the rational design of novel cancer therapeutics. My lab focuses on three main aspects of DNA replication control: I. The S-phase checkpoint, II. Trans-Lesion Synthesis (TLS) and III. Re-replication.

Awards and Honors

  • American Cancer Society New Investigator Award, 1997
  • American Cancer Society Institutional Junior Investigator Award, 1997
  • American Cancer Society Senior Post-doctoral Fellowship, 1996

Find publications on PubMed