Henrik Gunnar Dohlman

Henrik G. Dohlman, PhD, is a UNC Lineberger Comprehensive Cancer Center member and Sanford Steelman Distinguished Professor and Chair, Pharmacology,
Biochemistry and Biophysics.

PhD
Sanford Steelman Distinguished Professor and Chair, Pharmacology
Biochemistry and Biophysics
UNC-Chapel Hill
Cancer Cell Biology

Area of Interest

Our research is centered on heterotrimeric G proteins and G protein-coupled receptors (GPCRs). GPCRs are the target of one third of all pharmaceuticals, but persistent stimulation leads to desensitization. We conduct large-scale genomic and proteomic analysis to identify yeast variants with altered desensitization properties, which are then characterized biochemically and in cells. These efforts yielded the RGS family of GTPase-activating proteins, G protein signaling at endosomes, as well as dynamic regulation of G proteins by ubiquitination and pH second messengers.

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