James M. Coghill

James Coghill, MD, is a UNC Lineberger Comprehensive Cancer Center member and Assistant Professor of Medicine at UNC-Chapel Hill in the Division of Hematology and Oncology. Coghill holds specialties in Cancer.

Assistant Professor
UNC-Chapel Hill
Leukemia, Lymphoma, and Myeloma Program

Area of interest

I am a bone marrow transplant physician with a research interest in acute graft-versus-host disease (aGVHD), an auto-immune like complication that can develop after BMT. Our lab focuses on chemokine receptor biology and lymphocyte trafficking after transplant, with the overriding goal of developing never, more targeted aGVHD therapies. We are particularly interested in CC-Chemokine Receptor 7 (CCR7), a receptor critical for aGVHD pathogenesis. Our research group was the first to publish the structure of a validated CCR7 small molecule antagonist (cosalane), and the first to demonstrate its efficacy as a novel means to prevent aGVHD relevant murine BMT models.

Awards and Honors

  • 2000 Phi Kappa Phi Medical Honor Society
  • 2000 1st place in the Medical Student Research Symposium
  • 1999 Alpha Omega Alpha Medical Honor society (one of 8 students elected during their third year)
  • 1999 Sydney Barnam Scholarship for excellence on USMLE part I (99th percentile)
  • 1997 Negus Biochemistry Prize
  • 1997 Pathology Prize
  • 1997 Pathology Honor Society
  • 1996-1997 State Discretionary Scholarship
  • 1996 Phi Beta Kappa Honor Society

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