Assistant Professor, Genetics
Computational Medicine Program
Cancer Genetics, Breast Cancer
Area of Interest
The Hoadley Lab is focused on understanding the biology of cancer through gene expression analyses and integrative genomic approaches. We have been long time members of The Cancer Genome Atlas (TCGA) project that has comprehensively characterized over 10,000 samples from 33 tumor types. UNC was one of the main RNA sequencing centers for the TCGA project and we participated in the gene expression analysis for many of these projects. Our group is continuing our collaborative work as a member of the NCI’s Center for Cancer Genomics new Genomic Data Analysis Network as a specialized center for RNA sequencing analysis. We will build on the experience developed in TCGA to analyze data for new NCI programs and collaborations such as the Exceptional Responders and ALCHEMIST. In addition, the group still focuses on breast cancer through projects to improve our classification of aggressive basal-like breast cancers and genomic analysis of clinical trials.
Awards and Honors
- Highly Cited Researchers (Top 1%), Web of Science, Clarivate Analytics, 2022
- Marion R. Wright Award for Scientific Excellence, Breast Cancer Research Foundation, 2020
- Highly Cited Researchers (Top 1%), Web of Science, Clarivate Analytics, 2018
- Susan G. Komen North Carolina Triangle to the Coast Spirit to Impact Award – For supporting Survivors and being a catalyst for change in breast cancer outcomes, 2015
- Clinical Research Achievement Award, Clinical Research Forum, 2015
- Manuscript listed in the 2015 Clinical Cancer Advances: ASCO’s Annual Report on Progress Against Cancer, 2015
- Junior Faculty Development Award, The University of North Carolina at Chapel Hill, 2015
- Top Ten Clinical Research Achievement Award, Clinical Research Forum, 2015
- Weatherspoon Family Brain Tumor Research Award, 2011
News and Stories
Study identifies molecular differences between primary breast cancer and its metastases
A multi-institutional national study has identified unique molecular features responsible for the development and progression of metastatic breast cancer.
Immune system B-cells can help predict HER2-positive breast cancer treatment response
Researchers report specific immune system cells can help them determine whether HER2-positive breast cancer will respond to treatment.
UNC Lineberger faculty recognized as world’s most highly cited researchers
Twelve UNC Lineberger Comprehensive Cancer Center members were named to Clarivate’s 2022 Highly Cited Researchers list.
Genetic analysis of the most common type of bladder cancer in patients with metastatic disease yields guidance on treatment options
A genomic study of more than 200 people with the most common type of bladder cancer that has spread could help guide how the cancer would respond to immunotherapy.