MD, FASCO
The Richardson and Marilyn Jacobs Preyer Distinguished Professor in Breast Cancer Research
Deputy Director of Clinical Sciences
UNC-Chapel Hill
Breast Cancer
Clinical Research
Area of Interest
Lisa Carey’s research interests focus upon breast cancer, including examination of different subtypes of breast cancer, evaluation of new chemotherapy agents in early and metastatic breast cancer, and examination of tumor characteristics that predict response to therapy.
She has worked extensively with scientists across UNC Lineberger and the UNC Gillings Global School of Public Health to better understand and characterize the molecular subtypes of breast cancer so that we may develop better prevention and treatment strategies. With Drs. Perou and Millikan, she identified the elevated risk of the poor-prognosis basal-like breast cancer subtype in young African-American women. She is a world-wide expert in triple negative breast cancer, and led the first trial looking at a new drug regimen in this breast cancer subtype.
Her research spans the spectrum from early curative breast cancer to metastatic disease. She has worked extensively developing trials that use neoadjuvant, or preoperative, chemotherapy for breast cancer in order to address both clinical questions about the best regimens, as well as scientific questions regarding sensitivity or resistance to drugs. She led a large NCI-sponsored trial in HER2-positive breast cancer that examined dual HER2-targeting with two anti-HER2 drugs that found that while drug regimen was important in outcome, even more important were tumor characteristics such as subtype and evidence of immune cell activation. Based on this work, she has put together an international team looking at the molecular markers responsible this variation in response and survival, and her efforts as co-chair of the national cooperative group, Alliance, have resulted in two NCI trials examining these markers and optimizing treatment. In addition, she is actively involved in examining novel agents in metastatic breast cancer. Her Tumor Donation Program has contributed novel information regarding the genetic differences between the original primary breast cancer and the metastases in distant organs. This work in part spawned the AURORA-US multicenter initiative furthering this examination of the molecular landscape of metastatic disease; she serves on the Steering Committee for that effort.
She serves in national leadership roles, including as a member of the National Cancer Institute Breast Cancer Steering Committee, Co-Chair of the NCI-sponsored Alliance Breast Committee, Co-Chair of the Translational Breast Cancer Research Consortium Steering Committee, and member of the Board of Directors of the American Society of Clinical Oncology.
Awards and Honors
- Member, Board of Directors of the American Society of Clinical Oncology, 2020
- Fellow of the American Society of Clinical Oncology, 2019
- Member, Susan G. Komen Scientific Advisory Board, 2018
- UNC Healthcare System Excellence in Care Award, 2018
- Co-Chairperson, Breast Committee, Alliance for Clinical Trials in Oncology, 2016
News and Stories
AACR annual meeting to feature UNC Lineberger research
UNC Lineberger researchers and trainees will present nearly 20 research talks and presentations at the 2022 American Association for Cancer Research, April 8-13, in New Orleans.
Donor gives $25 million to establish UNC Lineberger Center for Triple Negative Breast Cancer
This is the largest donation in UNC Lineberger’s history, and it enables the cancer center to advance its groundbreaking research on diagnosing and treating a highly aggressive breast cancer that disproportionately affects Black, Latina and young women and historically has limited research funding.
Carey highlights progress in understanding and treating triple-negative breast cancer at San Antonio Breast Cancer Symposium
At the recent San Antonio Breast Cancer Symposium, Lisa A. Carey, MD, ScM, FASCO, presented a plenary talk on the latest developments in triple negative breast cancer.
National report on cancer offers hope, outlines challenges
Lisa A. Carey, MD, FASCO, says the report shows significant progress in some areas, but also outlines important shortcomings, especially in eliminating cancer-related racial disparities.
