MD, ScM, FASCO
The L. Richardson and Marilyn Jacobs Preyer Distinguished Professor for Breast Cancer Research
Deputy Director of Clinical Sciences
UNC-Chapel Hill
Breast Cancer
Clinical Research
Area of Interest
Lisa Carey, MD, ScM, FASCO, is an internationally recognized breast cancer physician-researcher who, in partnership with scientists at UNC-Chapel Hill and across the globe, is focused on advancing the understanding and characterization of molecular subtypes of breast cancer in order to develop more effective prevention and treatment strategies.
Carey is the L. Richardson and Marilyn Jacobs Preyer Distinguished Professor for Breast Cancer Research at the UNC School of Medicine, the Deputy Director of Clinical Sciences at UNC Lineberger Comprehensive Cancer Center, and the Director of the UNC Lineberger Center for Triple Negative Breast Cancer.
Her research interests focus upon breast cancer, including examination of different subtypes of breast cancer, evaluation of new chemotherapy agents in early and metastatic breast cancer, and examination of tumor characteristics that predict response to therapy.
She has worked extensively with scientists across UNC Lineberger and the UNC Gillings Global School of Public Health to better understand and characterize the molecular subtypes of breast cancer so that we may develop better prevention and treatment strategies. With Drs. Perou and Millikan, she identified the elevated risk of the poor-prognosis basal-like breast cancer subtype in young African-American women. She is a world-wide expert in triple negative breast cancer, and led the first trial looking at a new drug regimen in this breast cancer subtype.
Her research spans the spectrum from early curative breast cancer to metastatic disease. She has worked extensively developing trials that use neoadjuvant, or preoperative, chemotherapy for breast cancer in order to address both clinical questions about the best regimens, as well as scientific questions regarding sensitivity or resistance to drugs. She led a large NCI-sponsored trial in HER2-positive breast cancer that examined dual HER2-targeting with two anti-HER2 drugs that found that while drug regimen was important in outcome, even more important were tumor characteristics such as subtype and evidence of immune cell activation. Based on this work, she has put together an international team looking at the molecular markers responsible this variation in response and survival, and her efforts as co-chair of the national cooperative group, Alliance, have resulted in two NCI trials examining these markers and optimizing treatment. In addition, she is actively involved in examining novel agents in metastatic breast cancer. Her Tumor Donation Program has contributed novel information regarding the genetic differences between the original primary breast cancer and the metastases in distant organs. This work in part spawned the AURORA-US multicenter initiative furthering this examination of the molecular landscape of metastatic disease; she serves on the Steering Committee for that effort.
She serves in national leadership roles, including as a member of the National Cancer Institute Breast Cancer Steering Committee, Co-Chair of the NCI-sponsored Alliance Breast Committee, Co-Chair of the Translational Breast Cancer Research Consortium Steering Committee, and member of the Board of Directors of the American Society of Clinical Oncology.
Awards and Honors
- Member, Board of Directors of the American Society of Clinical Oncology, 2020
- Fellow of the American Society of Clinical Oncology, 2019
- Member, Susan G. Komen Scientific Advisory Board, 2018
- UNC Healthcare System Excellence in Care Award, 2018
- Co-Chairperson, Breast Committee, Alliance for Clinical Trials in Oncology, 2016
News and Stories
Scientific retreat underscores impact and promise of cancer center’s research
UNC Lineberger's annual scientific retreat brought together faculty, staff and trainees to learn about the latest research at the cancer center.
Leading investigators offer ‘highly scientific, but patient-focused’ talks on women’s cancers at symposium
UNC Lineberger’s 46th annual Scientific Symposium brought together more than 350 people in person and virtually to hear talks on the latest research on women’s cancers.
Study identifies molecular differences between primary breast cancer and its metastases
A multi-institutional national study has identified unique molecular features responsible for the development and progression of metastatic breast cancer.
Immune system B-cells can help predict HER2-positive breast cancer treatment response
Researchers report specific immune system cells can help them determine whether HER2-positive breast cancer will respond to treatment.
