Microbiology and Immunology
Area of interest
Su has had extensive research experience in human immunology, virology and stem cell biology, particularly in studying human immunopathology of chronic virus infections. His group was the first to use humanized mouse models to study HIV-1 infection and pathogenesis, and to develop human blood stem cell-based gene therapy for AIDS. Since joining the UNC faculty, his lab at UNC-Chapel Hill has made important findings in identifying novel virological and immunological mechanisms of HIV-1 pathogenesis. Furthermore, his lab has established humanized mouse models with both human immune and human liver cells that supports HCV or HBV infection, human immune responses and human liver fibrosis. In recent years, Su’s group has discovered and focused on the pDC-interferon axis in the immunopathogenesis and therapy of chronic HIV & HBV infections. The group has also started investigation of the pDC-IFN axis in tumor microenvironments (TME) and in cancer immune therapy.