Cancer Cell Biology
Area of interest
The long-term goals of my laboratory are to determine the molecular mechanisms through which long noncoding RNAs (lncRNAs) regulate gene expression, and to develop new methods to modulate lncRNA function for therapeutic gain. I have been studying RNA-mediated gene regulation since 2003 and epigenetic regulation governed by Xist and related lncRNAs since 2008. My faculty appointment began in March of 2014. Broadly, research in my lab focuses on understanding how intrinsic sequence elements within lncRNAs and the trans-acting factors that bind them cooperate to induce specific epigenetic states at targeted regions within mammalian genomes. My lab employs state-of-the-art genomic, cell biological, biochemical, and computational approaches to achieve our research goals. My main expertise is in developing and then applying novel genomic approaches to discover fundamental principles in gene regulation.