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Nicholas Brown is a UNC Lineberger Comprehensive Cancer Center member researching the cell cycle to influence the drug design of cancer therapeutics.

Associate Professor, Pharmacology
UNC-Chapel Hill
Cancer Cell Biology

Area of Interest

The overarching goal of my research program is to understand the system of inter- and intra-molecular interactions that dynamically regulate the catalytic mechanisms of enzymes to precisely time the events of the cell cycle. We employ a hybrid technological approach, including enzyme kinetics, mutagenesis, X-ray crystallography, NMR spectroscopy, and cryo-EM, to characterize these molecular machines. Our results provide mechanistic insight into the cell cycle that will influence the drug design of cancer therapeutics.

Find publications on PubMed

Awards and Honors

  • Jefferson-Pilot Fellowship in Academic Medicine, UNC-Chapel Hill, 2023-2024
  • University of North Carolina Lineberger Development Award, 2019
  • NIGMS Maximizing Investigators’ Research Award for Early Stage Investigators, 2018-2023
  • NCI K22 Career Transition Award, 2017-2018
  • Leukemia and Lymphoma Society Special Fellowship, 2015-2017
  • Jane Coffin Childs Memorial Fund for Medical Research Fellowship, 2012-2015
  • Gulf Coast Consortia/Keck Center Biomedical Discovery from Large Scale Data Sets Training Program Fellowship, 2010-2011
  • Gulf Coast Consortia/Keck Center Pharmacoinformatics Training Program Fellowship, 2008-2010
  • Baylor College of Medicine Verna and Marrs McLean Award, 2006
Headshot of Nicholas Brown