Nicholas G. Brown

Nicholas Brown is a UNC Lineberger Comprehensive Center member and Assistant Professor of Pharmacology. Brown Lab is interested in understanding how enzymes function by studying the cell processes in vitro.

Assistant Professor
UNC- Chapel Hill
Molecular Therapeutics

Area of interest

The overarching goal of my research program is to understand the system of inter- and intra-molecular interactions that dynamically regulate the catalytic mechanisms of enzymes to precisely time the events of the cell cycle. We employ a hybrid technological approach, including enzyme kinetics, mutagenesis, X-ray crystallography, NMR spectroscopy, and cryo-EM, to characterize these molecular machines. Our results provide mechanistic insight into the cell cycle that will influence the drug design of cancer therapeutics.

Awards and Honors

  • University of North Carolina Lineberger Development Award (2019)
  • NIGMS Maximizing Investigators’ Research Award for Early Stage Investigators (2018-2023)
  • NCI K22 Career Transition Award (2017-2018)
  • Leukemia and Lymphoma Society Special Fellowship (2015-2017)
  • Jane Coffin Childs Memorial Fund for Medical Research Fellowship (2012-2015)
  • Gulf Coast Consortia/Keck Center Biomedical Discovery from Large Scale Data Sets Training Program Fellowship (2010-2011)
  • Gulf Coast Consortia/Keck Center Pharmacoinformatics Training Program Fellowship (2008-2010)
  • Baylor College of Medicine Verna and Marrs McLean Award, 2006

Find publications on PubMed