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Herman and Louise Smith Distinguished Professor
Director, Thurston Arthritis Research Center
UNC-Chapel Hill
Cancer Cell Biology

Area of Interest

Loeser’s lab uses a combination of in vitro experiments using human joint tissue cells and in vivo experiments in rodent models to study cell signaling pathways that regulate anabolic and catabolic activity responsible for joint tissue remodeling and destruction. The lab is particularly interested in determining how reactive oxygen species regulate chondrocyte signaling and how oxidative stress that occurs with aging and joint injury can alter the activity of these signaling pathways. He has also worked in the area of clinical trials of exercise and weight loss interventions for adults with osteoarthritis of the knee. His cancer related research has included the effects of radiation on cartilage.

Awards and Honors

  • Elected to the American Clinical and Climatological Association, 2016
  • Osteoarthritis Research Society International Basic Science Research Award, 2014
  • Wake Forest School of Medicine Team Science Award, 2014
  • Wake Forest School of Medicine Established Investigator in Basic Sciences Award, 2013
  • MERIT award, National Institute of Arthritis, Musculoskeletal and Skin Diseases, 2012
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