PhD
Professor, Division of Chemical Biology and Medicinal Chemistry
UNC Eshelman School of Pharmacy
UNC-Chapel Hill
Molecular Therapeutics
Area of Interest
The research interests of the Liu laboratory focus on the development and application of novel drug target-binding affinity molecules through the integration of directed molecular selection and evolution, ligand design and engineering, in vitro cellular and signaling characterization, and in vivo therapeutic efficacy studies in tumor mouse models. We develop novel biologics with desired activities using integrated display technologies, including mRNA display, yeast surface display, phage display, and SELEX. We explore the translational potential of these biologics across modalities, including mRNA/LNP, protein/antibody, ligand-drug or ligand-radionuclide conjugate, and CAR-T. Additionally, we develop innovative targeted delivery strategies tailored for tumor- or cell type-specific administration of biologics of interest.
Awards and Honors
- Walter Winchell Postdoctoral Fellow of The Cancer Research Fund, Damon Runyon, 1997-2000
- NASA NSCORT Predoctoral Fellow, 1993-1996
News and Stories
Newly engineered molecule bypasses toxicity previously found in key cancer-fighting pathway
UNC Lineberger researchers have developed a molecule that is much more effective than a previously identified molecule at activating a biological pathway and spurring a strong anti-cancer immune response in preclinical studies.
Scientific retreat underscores impact and promise of cancer center’s research
UNC Lineberger's annual scientific retreat brought together faculty, staff and trainees to learn about the latest research at the cancer center.
Celebrating nearly 15 centuries of service
The University of North Carolina at Chapel Hill is recognizing 118 UNC Lineberger staff and faculty members who will be celebrating a service milestone this year.
