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Sha Chang

Sha Chang, PhD, is a UNC Lineberger Comprehensive Cancer Center member, Professor in the Department of Radiation Oncology.

UNC-Chapel Hill
Clinical Research
Clinical Profile

Area of interest

My current research interests include spatially-fractionated radiation therapy (SFRT) including microbeam radiation therapy technology development and preclinical research. SFRT remains to be a not-well-understood experimental therapy despite its tremendous promise as a high therapeutic ratio in cancer therapy. My work includes the invention and development of nanotechnology-enabled compact microbeam radiation therapy delivery system and preclinical SFRT preclinical research. For the latter, we investigate the effects of radiation spatial fractionation on tumor control and treatment toxicity in comparison to that of conventional radiation therapy. And what dosimetric parameters have close correlations with SFRT treatment outcome. We discovered that SFRT radiation modifies tumor microenvironment very differently than conventional radiation. We hypothesize that SFRT has promising potentials to be used safely as an induction therapy to enhance nanoparticle drug tumor delivery, anti-cancer immunotherapy, and conventional radiation therapy,

Awards and Honors

  • 2009 Program Director of the 3rd North Carolina IGRT/IMRT Symposium
  • 2009 Program Director of 2009 SEAAPM Chapter scientific meeting
  • 2009-2010 President, Southeast AAPM Chapter
  • 2008-2009 President-Elect, Southeast AAPM Chapter
  • 2000 present Section chair/ co-chair in AAPM annual meetings

Find publications on PubMed

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