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Young Wang, MD, PhD, is a UNC Lineberger Comprehensive Cancer Center member and medical oncologist specializing in genitourinary oncology.

Professor, Medicine-Oncology
UNC-Chapel Hill
Clinical Research
Urologic Oncology Program

Meet Young Whang

Area of Interest

My laboratory is interested in characterizing the role of cytoplasmic signaling pathways in regulation of androgen receptor activity and progression of prostate cancer. Our studies have focused on HER-2 receptor tyrosine kinase and we have demonstrated that HER-2 activation stimulates androgen receptor activity and HER-2 inhibition inhibits androgen receptor transcriptional function at the level of recruitment to the androgen responsive enhancers. These findings have led to the design and initiation of the protocol involving lapatinib, a clinical HER-2 inhibitor, in treatment of patients with prostate cancer. More recently, we have demonstrated that activated Cdc42-associated kinase Ack1 promotes progression of prostate cancer via tyrosine phosphorylation of androgen receptor at Tyr-267 and Tyr-363 residues. We are interested in further characterizing the role of tyrosine phosphorylation of androgen receptor in prostate cancer and development of Ack1 targeted therapy for clinical use.

  • We have shown that tyrosine kinases HER-2 and Ack1 regulate androgen receptor activity in prostate cancer cells and mapped phosphorylation sites in androgen receptor
  • We have designed and initiated a phase 2 clinical trial of lapatinib, the dual EGFR/HER-2 inhibitor, in patients with hormone refractory prostate cancer

Find publications on PubMed

Awards and Honors

  • NIH K08 Physician Scientist Award, 2000
  • Department of Defense Prostate Cancer Research Program New Investigator Award, 2000
  • Glaxo Wellcome Junior Faculty Award in Prostate Cancer Research, 1999

News and Stories

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    170 Manning Drive

    Houpt Physician Office Bldg. Rm. 3108

    CB #7305

    Chapel Hill, NC 27599