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Senescent cells: mammalian aging drivers or in vitro laboratory artifact?
March 8, 2019 @ 9:30 am - 10:30 am
Andrei Gudkov, PhD, DSc
Senior Vice President, Research Technology and Innovation
Garman Family Chair, Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Cellular senescence was initially defined as an in vitro phenomenon of DNA damage-induced irreversible proliferation arrest associated with constitutive production of pro-inflammatory factors. Aging of mammals has been attributed to accumulation of senescent cells that act as a source of systemic sterile inflammation causing frailty and increasing the risk of age-related diseases. However, our attempt to identify and follow senescent cells in vivo following systemic DNA damage has brought us to significant modifications of this popular paradigm.
Breakfast will be served.
Hosted by the Carolina Cancer Nanotechnology Training Program in the UNC Center for Nanotechnology in Drug Delivery